TMEM150B is dispensable for oocyte maturation and female fertility in mouse

Abstract Premature ovarian insufficiency (POI) refers to severe decline of ovary function in females which usually leads to infertility. It has been reported that the TMEM150B gene is mostly associated with age at natural menopause, early menopause and POI, but its role in female reproduction remain...

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Autores principales:	Ran Liu, Hanni Ke, Tong Shao, Yingying Qin, Shidou Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0d51e85a7b6e46f68057442587b172a3
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spelling	oai:doaj.org-article:0d51e85a7b6e46f68057442587b172a32021-12-02T11:41:41ZTMEM150B is dispensable for oocyte maturation and female fertility in mouse10.1038/s41598-020-78554-12045-2322https://doaj.org/article/0d51e85a7b6e46f68057442587b172a32020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78554-1https://doaj.org/toc/2045-2322Abstract Premature ovarian insufficiency (POI) refers to severe decline of ovary function in females which usually leads to infertility. It has been reported that the TMEM150B gene is mostly associated with age at natural menopause, early menopause and POI, but its role in female reproduction remains unknown. In this study, we found Tmem150b was highly expressed in mouse oocytes, but its deletion had no obvious effect on meiotic maturation of oocytes indicated by first polar body emission and spindle morphology. There were also no obvious differences in follicle development and corpus luteum formation between knockout and wild type mice. Finally, knockout of Tmem150b did not affect female fertility and sexual hormone levels. In summary, our results suggest that TMEM150B is not essential for female fertility in mice.Ran LiuHanni KeTong ShaoYingying QinShidou ZhaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ran Liu Hanni Ke Tong Shao Yingying Qin Shidou Zhao TMEM150B is dispensable for oocyte maturation and female fertility in mouse
description	Abstract Premature ovarian insufficiency (POI) refers to severe decline of ovary function in females which usually leads to infertility. It has been reported that the TMEM150B gene is mostly associated with age at natural menopause, early menopause and POI, but its role in female reproduction remains unknown. In this study, we found Tmem150b was highly expressed in mouse oocytes, but its deletion had no obvious effect on meiotic maturation of oocytes indicated by first polar body emission and spindle morphology. There were also no obvious differences in follicle development and corpus luteum formation between knockout and wild type mice. Finally, knockout of Tmem150b did not affect female fertility and sexual hormone levels. In summary, our results suggest that TMEM150B is not essential for female fertility in mice.
format	article
author	Ran Liu Hanni Ke Tong Shao Yingying Qin Shidou Zhao
author_facet	Ran Liu Hanni Ke Tong Shao Yingying Qin Shidou Zhao
author_sort	Ran Liu
title	TMEM150B is dispensable for oocyte maturation and female fertility in mouse
title_short	TMEM150B is dispensable for oocyte maturation and female fertility in mouse
title_full	TMEM150B is dispensable for oocyte maturation and female fertility in mouse
title_fullStr	TMEM150B is dispensable for oocyte maturation and female fertility in mouse
title_full_unstemmed	TMEM150B is dispensable for oocyte maturation and female fertility in mouse
title_sort	tmem150b is dispensable for oocyte maturation and female fertility in mouse
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0d51e85a7b6e46f68057442587b172a3
work_keys_str_mv	AT ranliu tmem150bisdispensableforoocytematurationandfemalefertilityinmouse AT hannike tmem150bisdispensableforoocytematurationandfemalefertilityinmouse AT tongshao tmem150bisdispensableforoocytematurationandfemalefertilityinmouse AT yingyingqin tmem150bisdispensableforoocytematurationandfemalefertilityinmouse AT shidouzhao tmem150bisdispensableforoocytematurationandfemalefertilityinmouse
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TMEM150B is dispensable for oocyte maturation and female fertility in mouse

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