Low bone mineral density is associated with global coronary atherosclerotic plaque burden in stable angina patients

Xue-qiang Guan,1 Yang-jing Xue,2 Jie Wang,2 Jun Ma,2 Yue-chun Li,2 Cheng Zheng,2 Sai-zhu Wu1 1Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 2Department of Cardiology, Second Affiliated Hospital of Wenzhou Medical University...

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Autores principales:	Guan XQ, Xue YJ, Wang J, Ma J, Li YC, Zheng C, Wu SZ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Coronary artery disease Bone mineral density Global coronary atherosclerotic plaque burden Modified Gensini score Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/0d5397fde404497683d2bb89aba99d9e
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spelling	oai:doaj.org-article:0d5397fde404497683d2bb89aba99d9e2021-12-02T03:45:17ZLow bone mineral density is associated with global coronary atherosclerotic plaque burden in stable angina patients1178-1998https://doaj.org/article/0d5397fde404497683d2bb89aba99d9e2018-08-01T00:00:00Zhttps://www.dovepress.com/low-bone-mineral-density-is-associated-with-global-coronary-atheroscle-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Xue-qiang Guan,1 Yang-jing Xue,2 Jie Wang,2 Jun Ma,2 Yue-chun Li,2 Cheng Zheng,2 Sai-zhu Wu1 1Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 2Department of Cardiology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China Background: Accelerated atherosclerosis is considered to be the linking factor between low bone mineral density (BMD) and increased cardiovascular events and mortality, while some coronary angiographic studies do not support this point. In this study, we attempt to provide a distinct comprehensive view of the relationship between BMD and the angiographically determined coronary atherosclerotic burden.Methods: A total of 459 consecutive patients with stable chest pain suspected of coronary artery disease (CAD) underwent both dual-energy X-ray absorptiometry scan and selective coronary angiography. The association between BMD and global coronary atherosclerotic plaque burden as represented by the multivessel involvement and the modified Gensini score was analyzed.Results: Multivariable analysis revealed that the low BMD at femoral neck and total hip was an independent correlate of multivessel CAD. The T-scores measured at femoral neck and total hip were both negatively and independently associated to the modified Gensini score. These inversely correlated relationships between BMD and CAD were not observed at lumbar spine 1–4.Conclusion: This cross-sectional study elucidated an inverse relationship between hip BMD and the modified Gensini score, and low hip BMD values (T-scores) were significantly and independently associated with increased risk of multivessel coronary disease in patients hospitalized for stable chest pain. Keywords: coronary artery disease, bone mineral density, global coronary atherosclerotic plaque burden, modified Gensini scoreGuan XQXue YJWang JMa JLi YCZheng CWu SZDove Medical PressarticleCoronary artery diseaseBone mineral densityGlobal coronary atherosclerotic plaque burdenModified Gensini scoreGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 1475-1483 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Coronary artery disease Bone mineral density Global coronary atherosclerotic plaque burden Modified Gensini score Geriatrics RC952-954.6
spellingShingle	Coronary artery disease Bone mineral density Global coronary atherosclerotic plaque burden Modified Gensini score Geriatrics RC952-954.6 Guan XQ Xue YJ Wang J Ma J Li YC Zheng C Wu SZ Low bone mineral density is associated with global coronary atherosclerotic plaque burden in stable angina patients
description	Xue-qiang Guan,1 Yang-jing Xue,2 Jie Wang,2 Jun Ma,2 Yue-chun Li,2 Cheng Zheng,2 Sai-zhu Wu1 1Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 2Department of Cardiology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China Background: Accelerated atherosclerosis is considered to be the linking factor between low bone mineral density (BMD) and increased cardiovascular events and mortality, while some coronary angiographic studies do not support this point. In this study, we attempt to provide a distinct comprehensive view of the relationship between BMD and the angiographically determined coronary atherosclerotic burden.Methods: A total of 459 consecutive patients with stable chest pain suspected of coronary artery disease (CAD) underwent both dual-energy X-ray absorptiometry scan and selective coronary angiography. The association between BMD and global coronary atherosclerotic plaque burden as represented by the multivessel involvement and the modified Gensini score was analyzed.Results: Multivariable analysis revealed that the low BMD at femoral neck and total hip was an independent correlate of multivessel CAD. The T-scores measured at femoral neck and total hip were both negatively and independently associated to the modified Gensini score. These inversely correlated relationships between BMD and CAD were not observed at lumbar spine 1–4.Conclusion: This cross-sectional study elucidated an inverse relationship between hip BMD and the modified Gensini score, and low hip BMD values (T-scores) were significantly and independently associated with increased risk of multivessel coronary disease in patients hospitalized for stable chest pain. Keywords: coronary artery disease, bone mineral density, global coronary atherosclerotic plaque burden, modified Gensini score
format	article
author	Guan XQ Xue YJ Wang J Ma J Li YC Zheng C Wu SZ
author_facet	Guan XQ Xue YJ Wang J Ma J Li YC Zheng C Wu SZ
author_sort	Guan XQ
title	Low bone mineral density is associated with global coronary atherosclerotic plaque burden in stable angina patients
title_short	Low bone mineral density is associated with global coronary atherosclerotic plaque burden in stable angina patients
title_full	Low bone mineral density is associated with global coronary atherosclerotic plaque burden in stable angina patients
title_fullStr	Low bone mineral density is associated with global coronary atherosclerotic plaque burden in stable angina patients
title_full_unstemmed	Low bone mineral density is associated with global coronary atherosclerotic plaque burden in stable angina patients
title_sort	low bone mineral density is associated with global coronary atherosclerotic plaque burden in stable angina patients
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/0d5397fde404497683d2bb89aba99d9e
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Low bone mineral density is associated with global coronary atherosclerotic plaque burden in stable angina patients

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