Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density

Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density

It has been thought that germinal center (GC) B cells with the highest density of peptide-MHCII molecules receive the most T cell help. Here the authors use heterozygous MHCII inactivation to instead show that after recruitment into the GCs, BCR affinity increases over time independent of the MHC de...

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Autores principales: Chen-Hao Yeh, Takuya Nojima, Masayuki Kuraoka, Garnett Kelsoe
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/0d56b5ab30ee4d05b71ea4b90b3b9db7
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spelling oai:doaj.org-article:0d56b5ab30ee4d05b71ea4b90b3b9db72021-12-02T16:49:52ZGerminal center entry not selection of B cells is controlled by peptide-MHCII complex density10.1038/s41467-018-03382-x2041-1723https://doaj.org/article/0d56b5ab30ee4d05b71ea4b90b3b9db72018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03382-xhttps://doaj.org/toc/2041-1723It has been thought that germinal center (GC) B cells with the highest density of peptide-MHCII molecules receive the most T cell help. Here the authors use heterozygous MHCII inactivation to instead show that after recruitment into the GCs, BCR affinity increases over time independent of the MHC density.Chen-Hao YehTakuya NojimaMasayuki KuraokaGarnett KelsoeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Chen-Hao Yeh
Takuya Nojima
Masayuki Kuraoka
Garnett Kelsoe
Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density
description It has been thought that germinal center (GC) B cells with the highest density of peptide-MHCII molecules receive the most T cell help. Here the authors use heterozygous MHCII inactivation to instead show that after recruitment into the GCs, BCR affinity increases over time independent of the MHC density.
format article
author Chen-Hao Yeh
Takuya Nojima
Masayuki Kuraoka
Garnett Kelsoe
author_facet Chen-Hao Yeh
Takuya Nojima
Masayuki Kuraoka
Garnett Kelsoe
author_sort Chen-Hao Yeh
title Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density
title_short Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density
title_full Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density
title_fullStr Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density
title_full_unstemmed Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density
title_sort germinal center entry not selection of b cells is controlled by peptide-mhcii complex density
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/0d56b5ab30ee4d05b71ea4b90b3b9db7
work_keys_str_mv AT chenhaoyeh germinalcenterentrynotselectionofbcellsiscontrolledbypeptidemhciicomplexdensity
AT takuyanojima germinalcenterentrynotselectionofbcellsiscontrolledbypeptidemhciicomplexdensity
AT masayukikuraoka germinalcenterentrynotselectionofbcellsiscontrolledbypeptidemhciicomplexdensity
AT garnettkelsoe germinalcenterentrynotselectionofbcellsiscontrolledbypeptidemhciicomplexdensity
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