Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization
The role of common fragile site associated genes such as FATS in the immune system is unclear. Here the authors show that deletion of Fats in a mouse tumour model leads to reduced tumour growth and change of macrophage phenotype from an M2-like to M1-like function.
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Nature Portfolio
2021
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| Acceso en línea: | https://doaj.org/article/0d57473fefd244258eb00c325b39d0e2 |
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oai:doaj.org-article:0d57473fefd244258eb00c325b39d0e22021-12-02T16:08:13ZLoss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization10.1038/s41467-021-24610-x2041-1723https://doaj.org/article/0d57473fefd244258eb00c325b39d0e22021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24610-xhttps://doaj.org/toc/2041-1723The role of common fragile site associated genes such as FATS in the immune system is unclear. Here the authors show that deletion of Fats in a mouse tumour model leads to reduced tumour growth and change of macrophage phenotype from an M2-like to M1-like function.Lijuan ZhangKai ZhangJieyou ZhangJinrong ZhuQing XiHuafeng WangZimu ZhangYingnan ChengGuangze YangHongkun LiuXiangdong GuoDongmei ZhouZhenyi XueYan LiQi ZhangYurong DaLi LiuZhinan YinZhi YaoRongxin ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Lijuan Zhang Kai Zhang Jieyou Zhang Jinrong Zhu Qing Xi Huafeng Wang Zimu Zhang Yingnan Cheng Guangze Yang Hongkun Liu Xiangdong Guo Dongmei Zhou Zhenyi Xue Yan Li Qi Zhang Yurong Da Li Liu Zhinan Yin Zhi Yao Rongxin Zhang Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization |
| description |
The role of common fragile site associated genes such as FATS in the immune system is unclear. Here the authors show that deletion of Fats in a mouse tumour model leads to reduced tumour growth and change of macrophage phenotype from an M2-like to M1-like function. |
| format |
article |
| author |
Lijuan Zhang Kai Zhang Jieyou Zhang Jinrong Zhu Qing Xi Huafeng Wang Zimu Zhang Yingnan Cheng Guangze Yang Hongkun Liu Xiangdong Guo Dongmei Zhou Zhenyi Xue Yan Li Qi Zhang Yurong Da Li Liu Zhinan Yin Zhi Yao Rongxin Zhang |
| author_facet |
Lijuan Zhang Kai Zhang Jieyou Zhang Jinrong Zhu Qing Xi Huafeng Wang Zimu Zhang Yingnan Cheng Guangze Yang Hongkun Liu Xiangdong Guo Dongmei Zhou Zhenyi Xue Yan Li Qi Zhang Yurong Da Li Liu Zhinan Yin Zhi Yao Rongxin Zhang |
| author_sort |
Lijuan Zhang |
| title |
Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization |
| title_short |
Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization |
| title_full |
Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization |
| title_fullStr |
Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization |
| title_full_unstemmed |
Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization |
| title_sort |
loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/0d57473fefd244258eb00c325b39d0e2 |
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| _version_ |
1718384575539838976 |