Colorectal cancer in the Linxian China Nutrition Intervention Trial: Risk factors and intervention results.

<h4>Background</h4>Colorectal cancer (CRC) is among the most common cancers in economically developed countries and developing world. While dietary factors are associated with risk of CRC in the West and urban China, little is known about risk or protective factors in rural China.<h4&...

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Autores principales:	Havva Keskin, Shao-Ming Wang, Arash Etemadi, Jin-Hu Fan, Sanford M Dawsey, Christian C Abnet, You-Lin Qiao, Philip R Taylor
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0d58ac55354a41d3aca7f8ef4f7f08aa
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spelling	oai:doaj.org-article:0d58ac55354a41d3aca7f8ef4f7f08aa2021-12-02T20:08:14ZColorectal cancer in the Linxian China Nutrition Intervention Trial: Risk factors and intervention results.1932-620310.1371/journal.pone.0255322https://doaj.org/article/0d58ac55354a41d3aca7f8ef4f7f08aa2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255322https://doaj.org/toc/1932-6203<h4>Background</h4>Colorectal cancer (CRC) is among the most common cancers in economically developed countries and developing world. While dietary factors are associated with risk of CRC in the West and urban China, little is known about risk or protective factors in rural China.<h4>Methods</h4>The Linxian General Population Nutrition Intervention Trial (NIT) cohort was established over 30 years ago to test whether daily multivitamin/mineral supplements could reduce the incidence and mortality of esophageal/gastric cardia cancer. The cohort included a total of 29,553 healthy participants 40-69 years old who were randomly assigned to supplements or placebos via a 24 fractional factorial study design. We examined risk factors for the development of CRC as well as the effects of four different nutritional factors (Factor A: retinol, zinc; B: riboflavin, niacin; C: ascorbic acid, molybdenum; D: selenium, alpha-tocopherol, beta-carotene,) on CRC incidence following 5.25 years of supplementation in this randomized, placebo-controlled intervention trial.<h4>Results</h4>CRC risk increased with age and height as well as piped water usage, family history of CRC, and consumption of foods cooked in oil, eggs, and fresh fruits. No effect on CRC was seen for any of these four intervention factors tested in both genders, but CRC was reduced 37% in females who received Factor D (selenium/alpha-tocopherol/beta-carotene) (RR = 0.63, 95% CI = 0.43-0.92, P = 0.016) compared to females who did not receive Factor D.<h4>Conclusions</h4>In this undernourished rural Chinese population, CRC risk factors in this Chinese cohort showed both similarities and differences compared to Western and urban Asian Chinese populations. Intervention results suggested a potential benefit for women supplemented with selenium/alpha-tocopherol/beta-carotene.Havva KeskinShao-Ming WangArash EtemadiJin-Hu FanSanford M DawseyChristian C AbnetYou-Lin QiaoPhilip R TaylorPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0255322 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Havva Keskin Shao-Ming Wang Arash Etemadi Jin-Hu Fan Sanford M Dawsey Christian C Abnet You-Lin Qiao Philip R Taylor Colorectal cancer in the Linxian China Nutrition Intervention Trial: Risk factors and intervention results.
description	<h4>Background</h4>Colorectal cancer (CRC) is among the most common cancers in economically developed countries and developing world. While dietary factors are associated with risk of CRC in the West and urban China, little is known about risk or protective factors in rural China.<h4>Methods</h4>The Linxian General Population Nutrition Intervention Trial (NIT) cohort was established over 30 years ago to test whether daily multivitamin/mineral supplements could reduce the incidence and mortality of esophageal/gastric cardia cancer. The cohort included a total of 29,553 healthy participants 40-69 years old who were randomly assigned to supplements or placebos via a 24 fractional factorial study design. We examined risk factors for the development of CRC as well as the effects of four different nutritional factors (Factor A: retinol, zinc; B: riboflavin, niacin; C: ascorbic acid, molybdenum; D: selenium, alpha-tocopherol, beta-carotene,) on CRC incidence following 5.25 years of supplementation in this randomized, placebo-controlled intervention trial.<h4>Results</h4>CRC risk increased with age and height as well as piped water usage, family history of CRC, and consumption of foods cooked in oil, eggs, and fresh fruits. No effect on CRC was seen for any of these four intervention factors tested in both genders, but CRC was reduced 37% in females who received Factor D (selenium/alpha-tocopherol/beta-carotene) (RR = 0.63, 95% CI = 0.43-0.92, P = 0.016) compared to females who did not receive Factor D.<h4>Conclusions</h4>In this undernourished rural Chinese population, CRC risk factors in this Chinese cohort showed both similarities and differences compared to Western and urban Asian Chinese populations. Intervention results suggested a potential benefit for women supplemented with selenium/alpha-tocopherol/beta-carotene.
format	article
author	Havva Keskin Shao-Ming Wang Arash Etemadi Jin-Hu Fan Sanford M Dawsey Christian C Abnet You-Lin Qiao Philip R Taylor
author_facet	Havva Keskin Shao-Ming Wang Arash Etemadi Jin-Hu Fan Sanford M Dawsey Christian C Abnet You-Lin Qiao Philip R Taylor
author_sort	Havva Keskin
title	Colorectal cancer in the Linxian China Nutrition Intervention Trial: Risk factors and intervention results.
title_short	Colorectal cancer in the Linxian China Nutrition Intervention Trial: Risk factors and intervention results.
title_full	Colorectal cancer in the Linxian China Nutrition Intervention Trial: Risk factors and intervention results.
title_fullStr	Colorectal cancer in the Linxian China Nutrition Intervention Trial: Risk factors and intervention results.
title_full_unstemmed	Colorectal cancer in the Linxian China Nutrition Intervention Trial: Risk factors and intervention results.
title_sort	colorectal cancer in the linxian china nutrition intervention trial: risk factors and intervention results.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0d58ac55354a41d3aca7f8ef4f7f08aa
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Colorectal cancer in the Linxian China Nutrition Intervention Trial: Risk factors and intervention results.

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