Aberrant attentive and inattentive brain activity to auditory negative words, and its relation to persecutory delusion in patients with schizophrenia

Norichika Iwashiro,1 Yosuke Takano,1 Tatsunobu Natsubori,1 Yuta Aoki,1 Noriaki Yahata,1,2 Wataru Gonoi,3 Akira Kunimatsu,3 Osamu Abe,3 Kiyoto Kasai,1 Hidenori Yamasue4 1Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan; 2Department of Molec...

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Autores principales:	Iwashiro N, Takano Y, Natsubori T, Aoki Y, Yahata N, Gonoi W, Kunimatsu A, Abe O, Kasai K, Yamasue H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Auditory perception Inferior frontal gyrus Emotion Language fMRI Psychosis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/0d595e37b2134f36ba4560cc4da250a2
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spelling	oai:doaj.org-article:0d595e37b2134f36ba4560cc4da250a22021-12-02T04:13:03ZAberrant attentive and inattentive brain activity to auditory negative words, and its relation to persecutory delusion in patients with schizophrenia1178-2021https://doaj.org/article/0d595e37b2134f36ba4560cc4da250a22019-02-01T00:00:00Zhttps://www.dovepress.com/aberrant-attentive-and-inattentive-brain-activity-to-auditory-negative-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Norichika Iwashiro,1 Yosuke Takano,1 Tatsunobu Natsubori,1 Yuta Aoki,1 Noriaki Yahata,1,2 Wataru Gonoi,3 Akira Kunimatsu,3 Osamu Abe,3 Kiyoto Kasai,1 Hidenori Yamasue4 1Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan; 2Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba-city, Chiba, Japan; 3Department of Radiology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan; 4Department of Psychiatry, Hamamatsu University School of Medicine, Higashi-ku, Hamamatsu City, Japan Background and purpose: Previous research has suggested that deficits in emotion recognition are involved in the pathogenesis of persecutory delusion in schizophrenia. Although disruption in auditory and language processing is crucial in the pathophysiology of schizophrenia, the neural basis for the deficits in emotion recognition of auditorily presented language stimuli and its relation to persecutory delusion have not yet been clarified. Patients and methods: The current functional magnetic resonance imaging study used a dichotic listening task for 15 patients with schizophrenia and 23 healthy controls matched for age, sex, parental socioeconomic background, handedness, dexterous ear, and intelligence quotient. The participants completed a word recognition task on the attended side in which a word with emotionally valenced content (negative/neutral) was presented to one ear and a different neutral word was presented to the other ear. Participants selectively attended to either ear. Results: The whole brain analysis detected the aberrant neural activity in the right inferior frontal gyrus in the patients with schizophrenia compared to that in the controls (P<0.05, false discovery rate-corrected). Brain activity in the right pars triangularis of the inferior frontal gyrus was significantly reduced when negatively valenced words were presented to the right ear, whereas the activity of the same region was significantly enhanced when these words were presented to the left ear, irrespective of the attended ear, in the participants with schizophrenia compared to the controls. Furthermore, this diminished brain response to auditorily presented negatively valenced words significantly correlated with severe positive symptoms (r=-0.67, P=0.006) and delusional behavior (r=-0.62, P=0.014) in the patients with schizophrenia. Conclusion: The present results indicate that the significantly impaired brain activity in response to auditorily presented negatively valenced words in the right pars triangularis of the inferior frontal gyrus is associated with the pathogenesis of positive symptoms such as persecutory delusion. Keywords: auditory perception, inferior frontal gyrus, emotion, language, functional magnetic resonance imaging, psychosisIwashiro NTakano YNatsubori TAoki YYahata NGonoi WKunimatsu AAbe OKasai KYamasue HDove Medical PressarticleAuditory perceptionInferior frontal gyrusEmotionLanguagefMRIPsychosisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 491-502 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Auditory perception Inferior frontal gyrus Emotion Language fMRI Psychosis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Auditory perception Inferior frontal gyrus Emotion Language fMRI Psychosis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Iwashiro N Takano Y Natsubori T Aoki Y Yahata N Gonoi W Kunimatsu A Abe O Kasai K Yamasue H Aberrant attentive and inattentive brain activity to auditory negative words, and its relation to persecutory delusion in patients with schizophrenia
description	Norichika Iwashiro,1 Yosuke Takano,1 Tatsunobu Natsubori,1 Yuta Aoki,1 Noriaki Yahata,1,2 Wataru Gonoi,3 Akira Kunimatsu,3 Osamu Abe,3 Kiyoto Kasai,1 Hidenori Yamasue4 1Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan; 2Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba-city, Chiba, Japan; 3Department of Radiology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan; 4Department of Psychiatry, Hamamatsu University School of Medicine, Higashi-ku, Hamamatsu City, Japan Background and purpose: Previous research has suggested that deficits in emotion recognition are involved in the pathogenesis of persecutory delusion in schizophrenia. Although disruption in auditory and language processing is crucial in the pathophysiology of schizophrenia, the neural basis for the deficits in emotion recognition of auditorily presented language stimuli and its relation to persecutory delusion have not yet been clarified. Patients and methods: The current functional magnetic resonance imaging study used a dichotic listening task for 15 patients with schizophrenia and 23 healthy controls matched for age, sex, parental socioeconomic background, handedness, dexterous ear, and intelligence quotient. The participants completed a word recognition task on the attended side in which a word with emotionally valenced content (negative/neutral) was presented to one ear and a different neutral word was presented to the other ear. Participants selectively attended to either ear. Results: The whole brain analysis detected the aberrant neural activity in the right inferior frontal gyrus in the patients with schizophrenia compared to that in the controls (P<0.05, false discovery rate-corrected). Brain activity in the right pars triangularis of the inferior frontal gyrus was significantly reduced when negatively valenced words were presented to the right ear, whereas the activity of the same region was significantly enhanced when these words were presented to the left ear, irrespective of the attended ear, in the participants with schizophrenia compared to the controls. Furthermore, this diminished brain response to auditorily presented negatively valenced words significantly correlated with severe positive symptoms (r=-0.67, P=0.006) and delusional behavior (r=-0.62, P=0.014) in the patients with schizophrenia. Conclusion: The present results indicate that the significantly impaired brain activity in response to auditorily presented negatively valenced words in the right pars triangularis of the inferior frontal gyrus is associated with the pathogenesis of positive symptoms such as persecutory delusion. Keywords: auditory perception, inferior frontal gyrus, emotion, language, functional magnetic resonance imaging, psychosis
format	article
author	Iwashiro N Takano Y Natsubori T Aoki Y Yahata N Gonoi W Kunimatsu A Abe O Kasai K Yamasue H
author_facet	Iwashiro N Takano Y Natsubori T Aoki Y Yahata N Gonoi W Kunimatsu A Abe O Kasai K Yamasue H
author_sort	Iwashiro N
title	Aberrant attentive and inattentive brain activity to auditory negative words, and its relation to persecutory delusion in patients with schizophrenia
title_short	Aberrant attentive and inattentive brain activity to auditory negative words, and its relation to persecutory delusion in patients with schizophrenia
title_full	Aberrant attentive and inattentive brain activity to auditory negative words, and its relation to persecutory delusion in patients with schizophrenia
title_fullStr	Aberrant attentive and inattentive brain activity to auditory negative words, and its relation to persecutory delusion in patients with schizophrenia
title_full_unstemmed	Aberrant attentive and inattentive brain activity to auditory negative words, and its relation to persecutory delusion in patients with schizophrenia
title_sort	aberrant attentive and inattentive brain activity to auditory negative words, and its relation to persecutory delusion in patients with schizophrenia
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/0d595e37b2134f36ba4560cc4da250a2
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Aberrant attentive and inattentive brain activity to auditory negative words, and its relation to persecutory delusion in patients with schizophrenia

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