Prenatal exposure to a polychlorinated biphenyl (PCB) congener influences fixation duration on biological motion at 4-months-old: a preliminary study.

Adverse effects of prenatal exposure to polychlorinated biphenyl (PCB) congeners on postnatal brain development have been reported in a number of previous studies. However, few studies have examined the effects of prenatal PCB exposure on early social development. The present study sought to increas...

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Autores principales:	Hirokazu Doi, Shota Nishitani, Takashi X Fujisawa, Tomoko Nagai, Masaki Kakeyama, Takahiro Maeda, Kazuyuki Shinohara
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0d5a5d639e954131a746f8352f715362
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spelling	oai:doaj.org-article:0d5a5d639e954131a746f8352f7153622021-11-18T07:51:38ZPrenatal exposure to a polychlorinated biphenyl (PCB) congener influences fixation duration on biological motion at 4-months-old: a preliminary study.1932-620310.1371/journal.pone.0059196https://doaj.org/article/0d5a5d639e954131a746f8352f7153622013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23555630/?tool=EBIhttps://doaj.org/toc/1932-6203Adverse effects of prenatal exposure to polychlorinated biphenyl (PCB) congeners on postnatal brain development have been reported in a number of previous studies. However, few studies have examined the effects of prenatal PCB exposure on early social development. The present study sought to increase understanding of the neurotoxicity of PCBs by examining the relationship between PCB congener concentrations in umbilical cord blood and fixation patterns when observing upright and inverted biological motion (BM) at four-months after birth. The development of the ability to recognize BM stimuli is considered a hallmark of socio-cognitive development. The results revealed a link between dioxin-like PCB #118 concentration and fixation pattern. Specifically, four-month-olds with a low-level of prenatal exposure to PCB #118 exhibited a preference for the upright BM over inverted BM, whereas those with a relatively high-level of exposure did not. This finding supports the proposal that prenatal PCB exposure impairs the development of social functioning, and indicates the importance of congener-specific analysis in the risk analysis of the adverse effects of PCB exposure on the brain development.Hirokazu DoiShota NishitaniTakashi X FujisawaTomoko NagaiMasaki KakeyamaTakahiro MaedaKazuyuki ShinoharaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e59196 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hirokazu Doi Shota Nishitani Takashi X Fujisawa Tomoko Nagai Masaki Kakeyama Takahiro Maeda Kazuyuki Shinohara Prenatal exposure to a polychlorinated biphenyl (PCB) congener influences fixation duration on biological motion at 4-months-old: a preliminary study.
description	Adverse effects of prenatal exposure to polychlorinated biphenyl (PCB) congeners on postnatal brain development have been reported in a number of previous studies. However, few studies have examined the effects of prenatal PCB exposure on early social development. The present study sought to increase understanding of the neurotoxicity of PCBs by examining the relationship between PCB congener concentrations in umbilical cord blood and fixation patterns when observing upright and inverted biological motion (BM) at four-months after birth. The development of the ability to recognize BM stimuli is considered a hallmark of socio-cognitive development. The results revealed a link between dioxin-like PCB #118 concentration and fixation pattern. Specifically, four-month-olds with a low-level of prenatal exposure to PCB #118 exhibited a preference for the upright BM over inverted BM, whereas those with a relatively high-level of exposure did not. This finding supports the proposal that prenatal PCB exposure impairs the development of social functioning, and indicates the importance of congener-specific analysis in the risk analysis of the adverse effects of PCB exposure on the brain development.
format	article
author	Hirokazu Doi Shota Nishitani Takashi X Fujisawa Tomoko Nagai Masaki Kakeyama Takahiro Maeda Kazuyuki Shinohara
author_facet	Hirokazu Doi Shota Nishitani Takashi X Fujisawa Tomoko Nagai Masaki Kakeyama Takahiro Maeda Kazuyuki Shinohara
author_sort	Hirokazu Doi
title	Prenatal exposure to a polychlorinated biphenyl (PCB) congener influences fixation duration on biological motion at 4-months-old: a preliminary study.
title_short	Prenatal exposure to a polychlorinated biphenyl (PCB) congener influences fixation duration on biological motion at 4-months-old: a preliminary study.
title_full	Prenatal exposure to a polychlorinated biphenyl (PCB) congener influences fixation duration on biological motion at 4-months-old: a preliminary study.
title_fullStr	Prenatal exposure to a polychlorinated biphenyl (PCB) congener influences fixation duration on biological motion at 4-months-old: a preliminary study.
title_full_unstemmed	Prenatal exposure to a polychlorinated biphenyl (PCB) congener influences fixation duration on biological motion at 4-months-old: a preliminary study.
title_sort	prenatal exposure to a polychlorinated biphenyl (pcb) congener influences fixation duration on biological motion at 4-months-old: a preliminary study.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/0d5a5d639e954131a746f8352f715362
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Prenatal exposure to a polychlorinated biphenyl (PCB) congener influences fixation duration on biological motion at 4-months-old: a preliminary study.

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