MET amplification identified by next-generation sequencing and its clinical relevance for MET inhibitors

MET amplification identified by next-generation sequencing and its clinical relevance for MET inhibitors

Abstract Background MET amplification plays an important role in the development of non-small-cell lung cancer (NSCLC) either de novo or in resistance to epidermal growth factor receptor tyrosine–kinase inhibitor (EGFR-TKI) settings. Fluorescence in situ hybridization (FISH) is the standard method f...

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Bibliographic Details
Main Authors: Lun-Xi Peng, Guang-Ling Jie, An-Na Li, Si-Yang Liu, Hao Sun, Mei-Mei Zheng, Jia-Ying Zhou, Jia-Tao Zhang, Xu-Chao Zhang, Qing Zhou, Wen-Zhao Zhong, Jin-Ji Yang, Hai-Yan Tu, Jian Su, Hong-Hong Yan, Yi-Long Wu
Format: article
Language:EN
Published: BMC 2021
Subjects:
FISH-NGS
MET amplification
Predictive factors
Survival benefits
Diseases of the blood and blood-forming organs
RC633-647.5
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Online Access:https://doaj.org/article/0d5dd8cd28a149f79236e148c0afbabe
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