Obsessive compulsive disorder networks: positron emission tomography and neuropsychology provide new insights.
<h4>Background</h4>Deep brain stimulation has shed new light on the central role of the prefrontal cortex (PFC) in obsessive compulsive disorder (OCD). We explored this structure from a functional perspective, synchronizing neuroimaging and cognitive measures.<h4>Methods and findin...
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oai:doaj.org-article:0d616540b87b4a3fa1d478df9394a8292021-11-18T08:01:52ZObsessive compulsive disorder networks: positron emission tomography and neuropsychology provide new insights.1932-620310.1371/journal.pone.0053241https://doaj.org/article/0d616540b87b4a3fa1d478df9394a8292013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23326403/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Deep brain stimulation has shed new light on the central role of the prefrontal cortex (PFC) in obsessive compulsive disorder (OCD). We explored this structure from a functional perspective, synchronizing neuroimaging and cognitive measures.<h4>Methods and findings</h4>This case-control cross-sectional study compared 15 OCD patients without comorbidities and not currently on serotonin reuptake inhibitors or cognitive behavioural therapy with 15 healthy controls (matched for age, sex and education level) on resting-state (18)FDG-PET scans and a neuropsychological battery assessing executive functions. We looked for correlations between metabolic modifications and impaired neuropsychological scores. Modifications in glucose metabolism were found in frontal regions (orbitofrontal cortex and dorsolateral cortices), the cingulate gyrus, insula and parietal gyrus. Neuropsychological differences between patients and controls, which were subtle, were correlated with the metabolism of the prefrontal, parietal, and temporal cortices.<h4>Conclusion</h4>As expected, we confirmed previous reports of a PFC dysfunction in OCD patients, and established a correlation with cognitive deficits. Other regions outside the prefrontal cortex, including the dorsoparietal cortex and the insula, also appeared to be implicated in the pathophysiology of OCD, providing fresh insights on the complexity of OCD syndromes.Bruno MilletThibaut DondaineJean-Michel ReymannAurélie BourguignonFlorian NaudetNematollah JaafariDominique DrapierValérie TurmelHabiba MesbahMarc VérinFlorence Le JeunePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e53241 (2013) |
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Medicine R Science Q Bruno Millet Thibaut Dondaine Jean-Michel Reymann Aurélie Bourguignon Florian Naudet Nematollah Jaafari Dominique Drapier Valérie Turmel Habiba Mesbah Marc Vérin Florence Le Jeune Obsessive compulsive disorder networks: positron emission tomography and neuropsychology provide new insights. |
| description |
<h4>Background</h4>Deep brain stimulation has shed new light on the central role of the prefrontal cortex (PFC) in obsessive compulsive disorder (OCD). We explored this structure from a functional perspective, synchronizing neuroimaging and cognitive measures.<h4>Methods and findings</h4>This case-control cross-sectional study compared 15 OCD patients without comorbidities and not currently on serotonin reuptake inhibitors or cognitive behavioural therapy with 15 healthy controls (matched for age, sex and education level) on resting-state (18)FDG-PET scans and a neuropsychological battery assessing executive functions. We looked for correlations between metabolic modifications and impaired neuropsychological scores. Modifications in glucose metabolism were found in frontal regions (orbitofrontal cortex and dorsolateral cortices), the cingulate gyrus, insula and parietal gyrus. Neuropsychological differences between patients and controls, which were subtle, were correlated with the metabolism of the prefrontal, parietal, and temporal cortices.<h4>Conclusion</h4>As expected, we confirmed previous reports of a PFC dysfunction in OCD patients, and established a correlation with cognitive deficits. Other regions outside the prefrontal cortex, including the dorsoparietal cortex and the insula, also appeared to be implicated in the pathophysiology of OCD, providing fresh insights on the complexity of OCD syndromes. |
| format |
article |
| author |
Bruno Millet Thibaut Dondaine Jean-Michel Reymann Aurélie Bourguignon Florian Naudet Nematollah Jaafari Dominique Drapier Valérie Turmel Habiba Mesbah Marc Vérin Florence Le Jeune |
| author_facet |
Bruno Millet Thibaut Dondaine Jean-Michel Reymann Aurélie Bourguignon Florian Naudet Nematollah Jaafari Dominique Drapier Valérie Turmel Habiba Mesbah Marc Vérin Florence Le Jeune |
| author_sort |
Bruno Millet |
| title |
Obsessive compulsive disorder networks: positron emission tomography and neuropsychology provide new insights. |
| title_short |
Obsessive compulsive disorder networks: positron emission tomography and neuropsychology provide new insights. |
| title_full |
Obsessive compulsive disorder networks: positron emission tomography and neuropsychology provide new insights. |
| title_fullStr |
Obsessive compulsive disorder networks: positron emission tomography and neuropsychology provide new insights. |
| title_full_unstemmed |
Obsessive compulsive disorder networks: positron emission tomography and neuropsychology provide new insights. |
| title_sort |
obsessive compulsive disorder networks: positron emission tomography and neuropsychology provide new insights. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/0d616540b87b4a3fa1d478df9394a829 |
| work_keys_str_mv |
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