Activities of daily living, depression, and quality of life in Parkinson's disease.

This study examined whether activities of daily living (ADL) mediate the relationship between depression and health-related quality of life (HR-QOL) in people with Parkinson's disease (PD). A cross-sectional, correlational research design examined data from 174 participants who completed the Ge...

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Autores principales:	Blake J Lawrence, Natalie Gasson, Robert Kane, Romola S Bucks, Andrea M Loftus
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0d621017bada44659c1c8021484e6027
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spelling	oai:doaj.org-article:0d621017bada44659c1c8021484e60272021-11-25T06:08:29ZActivities of daily living, depression, and quality of life in Parkinson's disease.1932-620310.1371/journal.pone.0102294https://doaj.org/article/0d621017bada44659c1c8021484e60272014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25025280/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203This study examined whether activities of daily living (ADL) mediate the relationship between depression and health-related quality of life (HR-QOL) in people with Parkinson's disease (PD). A cross-sectional, correlational research design examined data from 174 participants who completed the Geriatric Depression Scale (GDS-15), Parkinson's Disease Questionnaire-39 (PDQ-39), and Unified Parkinson's Disease Rating Scale-section 2 (UPDRS-section 2 [ADL]). Multiple Regression Analysis (MRA) was used to examine the mediator model. Depression and ADL significantly (p<.001) predicted HR-QOL, and depression significantly (p<.001) predicted ADL. Whilst ADL did not impact on the relationship between depression and HR-QOL, there was a significant (p<.001) indirect effect of depression on HR-QOL via ADL, suggesting both direct and indirect (via ADL) effects of depression on HR-QOL. The magnitude of this effect was moderate (R2 = .13). People with PD who report depression also experience greater difficulty completing ADL, which impacts upon their HR-QOL. It is recommended that clinicians adopt a multidisciplinary approach to care by combining pharmacological treatments with psycho/occupational therapy, thereby alleviating the heterogeneous impact of motor and non-motor symptoms on HR-QOL in people with PD.Blake J LawrenceNatalie GassonRobert KaneRomola S BucksAndrea M LoftusPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 7, p e102294 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Blake J Lawrence Natalie Gasson Robert Kane Romola S Bucks Andrea M Loftus Activities of daily living, depression, and quality of life in Parkinson's disease.
description	This study examined whether activities of daily living (ADL) mediate the relationship between depression and health-related quality of life (HR-QOL) in people with Parkinson's disease (PD). A cross-sectional, correlational research design examined data from 174 participants who completed the Geriatric Depression Scale (GDS-15), Parkinson's Disease Questionnaire-39 (PDQ-39), and Unified Parkinson's Disease Rating Scale-section 2 (UPDRS-section 2 [ADL]). Multiple Regression Analysis (MRA) was used to examine the mediator model. Depression and ADL significantly (p<.001) predicted HR-QOL, and depression significantly (p<.001) predicted ADL. Whilst ADL did not impact on the relationship between depression and HR-QOL, there was a significant (p<.001) indirect effect of depression on HR-QOL via ADL, suggesting both direct and indirect (via ADL) effects of depression on HR-QOL. The magnitude of this effect was moderate (R2 = .13). People with PD who report depression also experience greater difficulty completing ADL, which impacts upon their HR-QOL. It is recommended that clinicians adopt a multidisciplinary approach to care by combining pharmacological treatments with psycho/occupational therapy, thereby alleviating the heterogeneous impact of motor and non-motor symptoms on HR-QOL in people with PD.
format	article
author	Blake J Lawrence Natalie Gasson Robert Kane Romola S Bucks Andrea M Loftus
author_facet	Blake J Lawrence Natalie Gasson Robert Kane Romola S Bucks Andrea M Loftus
author_sort	Blake J Lawrence
title	Activities of daily living, depression, and quality of life in Parkinson's disease.
title_short	Activities of daily living, depression, and quality of life in Parkinson's disease.
title_full	Activities of daily living, depression, and quality of life in Parkinson's disease.
title_fullStr	Activities of daily living, depression, and quality of life in Parkinson's disease.
title_full_unstemmed	Activities of daily living, depression, and quality of life in Parkinson's disease.
title_sort	activities of daily living, depression, and quality of life in parkinson's disease.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/0d621017bada44659c1c8021484e6027
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Activities of daily living, depression, and quality of life in Parkinson's disease.

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