The sigma-1 receptor modulates methamphetamine dysregulation of dopamine neurotransmission

The sigma-1 receptor modulates methamphetamine dysregulation of dopamine neurotransmission

The dopamine transporter (DAT), a regulator of dopamine homeostasis in the brain, and sigma-1 receptor (σ1R), an endoplasmic reticulum membrane protein, are both implicated in drug addiction. In this work, the authors investigate how σ1R modulates DAT response to methamphetamine.

Guardado en:
Detalles Bibliográficos
Autores principales: Danielle O. Sambo, Min Lin, Anthony Owens, Joseph J. Lebowitz, Ben Richardson, Darin A. Jagnarine, Madhur Shetty, Meghan Rodriquez, Taiwo Alonge, Mishaal Ali, Jonathan Katz, Long Yan, Marcelo Febo, L. Keith Henry, Adriaan W. Bruijnzeel, Lynette Daws, Habibeh Khoshbouei
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/0d6245895b2e42a080e1391355fcd9ae
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:The dopamine transporter (DAT), a regulator of dopamine homeostasis in the brain, and sigma-1 receptor (σ1R), an endoplasmic reticulum membrane protein, are both implicated in drug addiction. In this work, the authors investigate how σ1R modulates DAT response to methamphetamine.

Ejemplares similares