Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia

The characteristics of immune cells in the peripheral nervous system (PNS) are not fully understood. Here the authors examine the transcriptomic profile and ontogeny of macrophages from the PNS, show they are derived from both embryonic and hematopoietic precursors, and that they have some shared fe...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Peter L. Wang, Aldrin K. Y. Yim, Ki-Wook Kim, Denis Avey, Rafael S. Czepielewski, Marco Colonna, Jeffrey Milbrandt, Gwendalyn J. Randolph
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0d62a1bd7b684c1da747077dfbc3f139
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0d62a1bd7b684c1da747077dfbc3f139
record_format	dspace
spelling	oai:doaj.org-article:0d62a1bd7b684c1da747077dfbc3f1392021-12-02T15:45:13ZPeripheral nerve resident macrophages share tissue-specific programming and features of activated microglia10.1038/s41467-020-16355-w2041-1723https://doaj.org/article/0d62a1bd7b684c1da747077dfbc3f1392020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16355-whttps://doaj.org/toc/2041-1723The characteristics of immune cells in the peripheral nervous system (PNS) are not fully understood. Here the authors examine the transcriptomic profile and ontogeny of macrophages from the PNS, show they are derived from both embryonic and hematopoietic precursors, and that they have some shared features with microglia.Peter L. WangAldrin K. Y. YimKi-Wook KimDenis AveyRafael S. CzepielewskiMarco ColonnaJeffrey MilbrandtGwendalyn J. RandolphNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peter L. Wang Aldrin K. Y. Yim Ki-Wook Kim Denis Avey Rafael S. Czepielewski Marco Colonna Jeffrey Milbrandt Gwendalyn J. Randolph Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia
description	The characteristics of immune cells in the peripheral nervous system (PNS) are not fully understood. Here the authors examine the transcriptomic profile and ontogeny of macrophages from the PNS, show they are derived from both embryonic and hematopoietic precursors, and that they have some shared features with microglia.
format	article
author	Peter L. Wang Aldrin K. Y. Yim Ki-Wook Kim Denis Avey Rafael S. Czepielewski Marco Colonna Jeffrey Milbrandt Gwendalyn J. Randolph
author_facet	Peter L. Wang Aldrin K. Y. Yim Ki-Wook Kim Denis Avey Rafael S. Czepielewski Marco Colonna Jeffrey Milbrandt Gwendalyn J. Randolph
author_sort	Peter L. Wang
title	Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia
title_short	Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia
title_full	Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia
title_fullStr	Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia
title_full_unstemmed	Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia
title_sort	peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0d62a1bd7b684c1da747077dfbc3f139
work_keys_str_mv	AT peterlwang peripheralnerveresidentmacrophagessharetissuespecificprogrammingandfeaturesofactivatedmicroglia AT aldrinkyyim peripheralnerveresidentmacrophagessharetissuespecificprogrammingandfeaturesofactivatedmicroglia AT kiwookkim peripheralnerveresidentmacrophagessharetissuespecificprogrammingandfeaturesofactivatedmicroglia AT denisavey peripheralnerveresidentmacrophagessharetissuespecificprogrammingandfeaturesofactivatedmicroglia AT rafaelsczepielewski peripheralnerveresidentmacrophagessharetissuespecificprogrammingandfeaturesofactivatedmicroglia AT marcocolonna peripheralnerveresidentmacrophagessharetissuespecificprogrammingandfeaturesofactivatedmicroglia AT jeffreymilbrandt peripheralnerveresidentmacrophagessharetissuespecificprogrammingandfeaturesofactivatedmicroglia AT gwendalynjrandolph peripheralnerveresidentmacrophagessharetissuespecificprogrammingandfeaturesofactivatedmicroglia
_version_	1718385733624922112

Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia

Ejemplares similares