NOTCH and EZH2 collaborate to repress PTEN expression in breast cancer

Pappas et al. show that the combination of NOTCH and EZH2 alterations drive transcriptional repression of PTEN through reversible epigenetic modification of the PTEN promoter. These results suggest an actionable target for treating poor-prognosis breast cancer.

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Autores principales:	Kyrie Pappas, Tiphaine C. Martin, Andrew L. Wolfe, Christie B. Nguyen, Tao Su, Jian Jin, Hanina Hibshoosh, Ramon Parsons
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0d639da6ef5d412789a11baff7e2a9fe
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:0d639da6ef5d412789a11baff7e2a9fe2021-12-02T13:19:27ZNOTCH and EZH2 collaborate to repress PTEN expression in breast cancer10.1038/s42003-021-01825-82399-3642https://doaj.org/article/0d639da6ef5d412789a11baff7e2a9fe2021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01825-8https://doaj.org/toc/2399-3642Pappas et al. show that the combination of NOTCH and EZH2 alterations drive transcriptional repression of PTEN through reversible epigenetic modification of the PTEN promoter. These results suggest an actionable target for treating poor-prognosis breast cancer.Kyrie PappasTiphaine C. MartinAndrew L. WolfeChristie B. NguyenTao SuJian JinHanina HibshooshRamon ParsonsNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Kyrie Pappas Tiphaine C. Martin Andrew L. Wolfe Christie B. Nguyen Tao Su Jian Jin Hanina Hibshoosh Ramon Parsons NOTCH and EZH2 collaborate to repress PTEN expression in breast cancer
description	Pappas et al. show that the combination of NOTCH and EZH2 alterations drive transcriptional repression of PTEN through reversible epigenetic modification of the PTEN promoter. These results suggest an actionable target for treating poor-prognosis breast cancer.
format	article
author	Kyrie Pappas Tiphaine C. Martin Andrew L. Wolfe Christie B. Nguyen Tao Su Jian Jin Hanina Hibshoosh Ramon Parsons
author_facet	Kyrie Pappas Tiphaine C. Martin Andrew L. Wolfe Christie B. Nguyen Tao Su Jian Jin Hanina Hibshoosh Ramon Parsons
author_sort	Kyrie Pappas
title	NOTCH and EZH2 collaborate to repress PTEN expression in breast cancer
title_short	NOTCH and EZH2 collaborate to repress PTEN expression in breast cancer
title_full	NOTCH and EZH2 collaborate to repress PTEN expression in breast cancer
title_fullStr	NOTCH and EZH2 collaborate to repress PTEN expression in breast cancer
title_full_unstemmed	NOTCH and EZH2 collaborate to repress PTEN expression in breast cancer
title_sort	notch and ezh2 collaborate to repress pten expression in breast cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0d639da6ef5d412789a11baff7e2a9fe
work_keys_str_mv	AT kyriepappas notchandezh2collaboratetorepressptenexpressioninbreastcancer AT tiphainecmartin notchandezh2collaboratetorepressptenexpressioninbreastcancer AT andrewlwolfe notchandezh2collaboratetorepressptenexpressioninbreastcancer AT christiebnguyen notchandezh2collaboratetorepressptenexpressioninbreastcancer AT taosu notchandezh2collaboratetorepressptenexpressioninbreastcancer AT jianjin notchandezh2collaboratetorepressptenexpressioninbreastcancer AT haninahibshoosh notchandezh2collaboratetorepressptenexpressioninbreastcancer AT ramonparsons notchandezh2collaboratetorepressptenexpressioninbreastcancer
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NOTCH and EZH2 collaborate to repress PTEN expression in breast cancer

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