Desmoglein-2 harnesses a PDZ-GEF2/Rap1 signaling axis to control cell spreading and focal adhesions independent of cell–cell adhesion

Abstract Desmosomes have a central role in mediating extracellular adhesion between cells, but they also coordinate other biological processes such as proliferation, differentiation, apoptosis and migration. In particular, several lines of evidence have implicated desmosomal proteins in regulating t...

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Autores principales: W. Tucker Shelton, S. Madison Thomas, Hunter R. Alexander, C. Evan Thomes, Daniel E. Conway, Adi D. Dubash
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/0d65ae5d5c894deaaddbec4c97f9ac2f
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