The joint involvement in adult onset Still's disease is characterised by a peculiar magnetic resonance imaging and a specific transcriptomic profile

Abstract Adult onset Still's disease (AOSD) is a rare systemic autoinflammatory disease, characterised by fever, arthritis, and skin rash, and joint involvement is one of its clinical manifestations. The aims of this work were to assess joint involvement, to describe main patterns of involvemen...

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Autores principales:	Piero Ruscitti, Antonio Barile, Onorina Berardicurti, Sonia Iafrate, Paola Di Benedetto, Antonio Vitale, Francesco Caso, Luisa Costa, Federico Bruno, Francesco Ursini, Luca Navarini, Federica Sensini, Raffaele Scarpa, Bruno Frediani, Luca Cantarini, Carlo Masciocchi, Roberto Giacomelli, Paola Cipriani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0d68520867b94e65879e4c68a035ef8b
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spelling	oai:doaj.org-article:0d68520867b94e65879e4c68a035ef8b2021-12-02T17:41:28ZThe joint involvement in adult onset Still's disease is characterised by a peculiar magnetic resonance imaging and a specific transcriptomic profile10.1038/s41598-021-91613-52045-2322https://doaj.org/article/0d68520867b94e65879e4c68a035ef8b2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91613-5https://doaj.org/toc/2045-2322Abstract Adult onset Still's disease (AOSD) is a rare systemic autoinflammatory disease, characterised by fever, arthritis, and skin rash, and joint involvement is one of its clinical manifestations. The aims of this work were to assess joint involvement, to describe main patterns of involvement, and associated clinical characteristics. In this work, we aimed at assessing the joint involvement in AOSD by using MRI, to describe main patterns and associated clinical characteristics. In addition, we aimed at assessing the global transcriptomic profile of synovial tissues in AOSD to elucidate possible pathogenic pathways involved. We also evaluated the global transcriptomic profile of synovial tissues to elucidate possible pathogenic pathways involved in the disease. Thus, AOSD patients, who underwent to MRI exam on joints, were assessed to describe patterns of joint involvement and associated clinical characteristics. Some synovial tissues were collected for RNA-sequencing purposes. The most common MRI finding was the presence of synovitis on 60.5%, mainly in peripheral affected joints, with low to intermediate signal intensity on T1-weighted images and intermediate to high signal intensity on T2-fat-saturated weighted and STIR images. Bone oedema and MRI-bone erosions were reported on 34.9% and 25.6% MRI exams, respectively. Patients with MRI-bone erosions showed a higher prevalence of splenomegaly, a more frequent chronic disease course, lower levels of erythrocyte sedimentation rate, and ferritin. In AOSD synovial tissues, a hyper-expression of interleukin (IL)-1, IL-6, and TNF pathways was shown together with ferritin genes. In conclusion, in AOSD patients, the most common MRI-finding was the presence of synovitis, characterised by intermediate to high signal intensity on T2-fat-saturated weighted and STIR images. MRI-bone erosions and bone oedema were also observed. In AOSD synovial tissues, IL-1, IL-6, and TNF pathways together with ferritin genes resulted to be hyper-expressed.Piero RuscittiAntonio BarileOnorina BerardicurtiSonia IafratePaola Di BenedettoAntonio VitaleFrancesco CasoLuisa CostaFederico BrunoFrancesco UrsiniLuca NavariniFederica SensiniRaffaele ScarpaBruno FredianiLuca CantariniCarlo MasciocchiRoberto GiacomelliPaola CiprianiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Piero Ruscitti Antonio Barile Onorina Berardicurti Sonia Iafrate Paola Di Benedetto Antonio Vitale Francesco Caso Luisa Costa Federico Bruno Francesco Ursini Luca Navarini Federica Sensini Raffaele Scarpa Bruno Frediani Luca Cantarini Carlo Masciocchi Roberto Giacomelli Paola Cipriani The joint involvement in adult onset Still's disease is characterised by a peculiar magnetic resonance imaging and a specific transcriptomic profile
description	Abstract Adult onset Still's disease (AOSD) is a rare systemic autoinflammatory disease, characterised by fever, arthritis, and skin rash, and joint involvement is one of its clinical manifestations. The aims of this work were to assess joint involvement, to describe main patterns of involvement, and associated clinical characteristics. In this work, we aimed at assessing the joint involvement in AOSD by using MRI, to describe main patterns and associated clinical characteristics. In addition, we aimed at assessing the global transcriptomic profile of synovial tissues in AOSD to elucidate possible pathogenic pathways involved. We also evaluated the global transcriptomic profile of synovial tissues to elucidate possible pathogenic pathways involved in the disease. Thus, AOSD patients, who underwent to MRI exam on joints, were assessed to describe patterns of joint involvement and associated clinical characteristics. Some synovial tissues were collected for RNA-sequencing purposes. The most common MRI finding was the presence of synovitis on 60.5%, mainly in peripheral affected joints, with low to intermediate signal intensity on T1-weighted images and intermediate to high signal intensity on T2-fat-saturated weighted and STIR images. Bone oedema and MRI-bone erosions were reported on 34.9% and 25.6% MRI exams, respectively. Patients with MRI-bone erosions showed a higher prevalence of splenomegaly, a more frequent chronic disease course, lower levels of erythrocyte sedimentation rate, and ferritin. In AOSD synovial tissues, a hyper-expression of interleukin (IL)-1, IL-6, and TNF pathways was shown together with ferritin genes. In conclusion, in AOSD patients, the most common MRI-finding was the presence of synovitis, characterised by intermediate to high signal intensity on T2-fat-saturated weighted and STIR images. MRI-bone erosions and bone oedema were also observed. In AOSD synovial tissues, IL-1, IL-6, and TNF pathways together with ferritin genes resulted to be hyper-expressed.
format	article
author	Piero Ruscitti Antonio Barile Onorina Berardicurti Sonia Iafrate Paola Di Benedetto Antonio Vitale Francesco Caso Luisa Costa Federico Bruno Francesco Ursini Luca Navarini Federica Sensini Raffaele Scarpa Bruno Frediani Luca Cantarini Carlo Masciocchi Roberto Giacomelli Paola Cipriani
author_facet	Piero Ruscitti Antonio Barile Onorina Berardicurti Sonia Iafrate Paola Di Benedetto Antonio Vitale Francesco Caso Luisa Costa Federico Bruno Francesco Ursini Luca Navarini Federica Sensini Raffaele Scarpa Bruno Frediani Luca Cantarini Carlo Masciocchi Roberto Giacomelli Paola Cipriani
author_sort	Piero Ruscitti
title	The joint involvement in adult onset Still's disease is characterised by a peculiar magnetic resonance imaging and a specific transcriptomic profile
title_short	The joint involvement in adult onset Still's disease is characterised by a peculiar magnetic resonance imaging and a specific transcriptomic profile
title_full	The joint involvement in adult onset Still's disease is characterised by a peculiar magnetic resonance imaging and a specific transcriptomic profile
title_fullStr	The joint involvement in adult onset Still's disease is characterised by a peculiar magnetic resonance imaging and a specific transcriptomic profile
title_full_unstemmed	The joint involvement in adult onset Still's disease is characterised by a peculiar magnetic resonance imaging and a specific transcriptomic profile
title_sort	joint involvement in adult onset still's disease is characterised by a peculiar magnetic resonance imaging and a specific transcriptomic profile
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0d68520867b94e65879e4c68a035ef8b
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The joint involvement in adult onset Still's disease is characterised by a peculiar magnetic resonance imaging and a specific transcriptomic profile

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