Association between smoking status and outcomes in myocardial infarction patients undergoing percutaneous coronary intervention

Abstract Smoking is one of the leading risk factors for cardiovascular diseases, including ischemic heart disease and hypertension. However, in acute myocardial infarction (AMI) patients, smoking has been associated with better clinical outcomes, a phenomenon termed the “smoker’s paradox.” Given the...

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Autores principales:	Ching-Hui Sia, Junsuk Ko, Huili Zheng, Andrew Fu-Wah Ho, David Foo, Ling-Li Foo, Patrick Zhan-Yun Lim, Boon Wah Liew, Ping Chai, Tiong-Cheng Yeo, Huay-Cheem Tan, Terrance Chua, Mark Yan-Yee Chan, Jack Wei Chieh Tan, Heerajnarain Bulluck, Derek J. Hausenloy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0d69761aabfd43e18984afcc1b15e41f
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spelling	oai:doaj.org-article:0d69761aabfd43e18984afcc1b15e41f2021-12-02T17:05:46ZAssociation between smoking status and outcomes in myocardial infarction patients undergoing percutaneous coronary intervention10.1038/s41598-021-86003-w2045-2322https://doaj.org/article/0d69761aabfd43e18984afcc1b15e41f2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86003-whttps://doaj.org/toc/2045-2322Abstract Smoking is one of the leading risk factors for cardiovascular diseases, including ischemic heart disease and hypertension. However, in acute myocardial infarction (AMI) patients, smoking has been associated with better clinical outcomes, a phenomenon termed the “smoker’s paradox.” Given the known detrimental effects of smoking on the cardiovascular system, it has been proposed that the beneficial effect of smoking on outcomes is due to age differences between smokers and non-smokers and is therefore a smoker’s pseudoparadox. The aim of this study was to evaluate the association between smoking status and clinical outcomes in ST-segment elevation (STEMI) and non-STEMI (NSTEMI) patients treated by percutaneous coronary intervention (PCI), using a national multi-ethnic Asian registry. In unadjusted analyses, current smokers had better clinical outcomes following STEMI and NSTEMI. However, after adjusting for age, the protective effect of smoking was lost, confirming a smoker’s pseudoparadox. Interestingly, although current smokers had increased risk for recurrent MI within 1 year after PCI in both STEMI and NSTEMI patients, there was no increase in mortality. In summary, we confirm the existence of a smoker’s pseudoparadox in a multi-ethnic Asian cohort of STEMI and NSTEMI patients and report increased risk of recurrent MI, but not mortality, in smokers.Ching-Hui SiaJunsuk KoHuili ZhengAndrew Fu-Wah HoDavid FooLing-Li FooPatrick Zhan-Yun LimBoon Wah LiewPing ChaiTiong-Cheng YeoHuay-Cheem TanTerrance ChuaMark Yan-Yee ChanJack Wei Chieh TanHeerajnarain BulluckDerek J. HausenloyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ching-Hui Sia Junsuk Ko Huili Zheng Andrew Fu-Wah Ho David Foo Ling-Li Foo Patrick Zhan-Yun Lim Boon Wah Liew Ping Chai Tiong-Cheng Yeo Huay-Cheem Tan Terrance Chua Mark Yan-Yee Chan Jack Wei Chieh Tan Heerajnarain Bulluck Derek J. Hausenloy Association between smoking status and outcomes in myocardial infarction patients undergoing percutaneous coronary intervention
description	Abstract Smoking is one of the leading risk factors for cardiovascular diseases, including ischemic heart disease and hypertension. However, in acute myocardial infarction (AMI) patients, smoking has been associated with better clinical outcomes, a phenomenon termed the “smoker’s paradox.” Given the known detrimental effects of smoking on the cardiovascular system, it has been proposed that the beneficial effect of smoking on outcomes is due to age differences between smokers and non-smokers and is therefore a smoker’s pseudoparadox. The aim of this study was to evaluate the association between smoking status and clinical outcomes in ST-segment elevation (STEMI) and non-STEMI (NSTEMI) patients treated by percutaneous coronary intervention (PCI), using a national multi-ethnic Asian registry. In unadjusted analyses, current smokers had better clinical outcomes following STEMI and NSTEMI. However, after adjusting for age, the protective effect of smoking was lost, confirming a smoker’s pseudoparadox. Interestingly, although current smokers had increased risk for recurrent MI within 1 year after PCI in both STEMI and NSTEMI patients, there was no increase in mortality. In summary, we confirm the existence of a smoker’s pseudoparadox in a multi-ethnic Asian cohort of STEMI and NSTEMI patients and report increased risk of recurrent MI, but not mortality, in smokers.
format	article
author	Ching-Hui Sia Junsuk Ko Huili Zheng Andrew Fu-Wah Ho David Foo Ling-Li Foo Patrick Zhan-Yun Lim Boon Wah Liew Ping Chai Tiong-Cheng Yeo Huay-Cheem Tan Terrance Chua Mark Yan-Yee Chan Jack Wei Chieh Tan Heerajnarain Bulluck Derek J. Hausenloy
author_facet	Ching-Hui Sia Junsuk Ko Huili Zheng Andrew Fu-Wah Ho David Foo Ling-Li Foo Patrick Zhan-Yun Lim Boon Wah Liew Ping Chai Tiong-Cheng Yeo Huay-Cheem Tan Terrance Chua Mark Yan-Yee Chan Jack Wei Chieh Tan Heerajnarain Bulluck Derek J. Hausenloy
author_sort	Ching-Hui Sia
title	Association between smoking status and outcomes in myocardial infarction patients undergoing percutaneous coronary intervention
title_short	Association between smoking status and outcomes in myocardial infarction patients undergoing percutaneous coronary intervention
title_full	Association between smoking status and outcomes in myocardial infarction patients undergoing percutaneous coronary intervention
title_fullStr	Association between smoking status and outcomes in myocardial infarction patients undergoing percutaneous coronary intervention
title_full_unstemmed	Association between smoking status and outcomes in myocardial infarction patients undergoing percutaneous coronary intervention
title_sort	association between smoking status and outcomes in myocardial infarction patients undergoing percutaneous coronary intervention
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0d69761aabfd43e18984afcc1b15e41f
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Association between smoking status and outcomes in myocardial infarction patients undergoing percutaneous coronary intervention

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