Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation

The CCR4-NOT complex shortens poly(A) tails of messenger RNAs. By biochemical reconstitution of the entire human CCR4-NOT complex, the authors show the stimulatory roles of non-enzymatic subunits and the importance of the interaction between CAF40 and RNA binding proteins in targeted deadenylation.

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Autores principales:	Tobias Raisch, Chung-Te Chang, Yevgen Levdansky, Sowndarya Muthukumar, Stefan Raunser, Eugene Valkov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0d6ba84b2a914940b58d2a4de867487b
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spelling	oai:doaj.org-article:0d6ba84b2a914940b58d2a4de867487b2021-12-02T15:36:21ZReconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation10.1038/s41467-019-11094-z2041-1723https://doaj.org/article/0d6ba84b2a914940b58d2a4de867487b2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11094-zhttps://doaj.org/toc/2041-1723The CCR4-NOT complex shortens poly(A) tails of messenger RNAs. By biochemical reconstitution of the entire human CCR4-NOT complex, the authors show the stimulatory roles of non-enzymatic subunits and the importance of the interaction between CAF40 and RNA binding proteins in targeted deadenylation.Tobias RaischChung-Te ChangYevgen LevdanskySowndarya MuthukumarStefan RaunserEugene ValkovNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tobias Raisch Chung-Te Chang Yevgen Levdansky Sowndarya Muthukumar Stefan Raunser Eugene Valkov Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation
description	The CCR4-NOT complex shortens poly(A) tails of messenger RNAs. By biochemical reconstitution of the entire human CCR4-NOT complex, the authors show the stimulatory roles of non-enzymatic subunits and the importance of the interaction between CAF40 and RNA binding proteins in targeted deadenylation.
format	article
author	Tobias Raisch Chung-Te Chang Yevgen Levdansky Sowndarya Muthukumar Stefan Raunser Eugene Valkov
author_facet	Tobias Raisch Chung-Te Chang Yevgen Levdansky Sowndarya Muthukumar Stefan Raunser Eugene Valkov
author_sort	Tobias Raisch
title	Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation
title_short	Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation
title_full	Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation
title_fullStr	Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation
title_full_unstemmed	Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation
title_sort	reconstitution of recombinant human ccr4-not reveals molecular insights into regulated deadenylation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0d6ba84b2a914940b58d2a4de867487b
work_keys_str_mv	AT tobiasraisch reconstitutionofrecombinanthumanccr4notrevealsmolecularinsightsintoregulateddeadenylation AT chungtechang reconstitutionofrecombinanthumanccr4notrevealsmolecularinsightsintoregulateddeadenylation AT yevgenlevdansky reconstitutionofrecombinanthumanccr4notrevealsmolecularinsightsintoregulateddeadenylation AT sowndaryamuthukumar reconstitutionofrecombinanthumanccr4notrevealsmolecularinsightsintoregulateddeadenylation AT stefanraunser reconstitutionofrecombinanthumanccr4notrevealsmolecularinsightsintoregulateddeadenylation AT eugenevalkov reconstitutionofrecombinanthumanccr4notrevealsmolecularinsightsintoregulateddeadenylation
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Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation

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