The use of N-acetylcysteine in the prevention of hangover: a randomized trial

Abstract Hangovers resulting from alcohol intoxication can lead to adverse effects ranging from generalized discomfort and work-related absenteeism to emergency department visits from patients seeking symptomatic care. The purpose of this study was to evaluate the efficacy of a low dose (600–1800 mg...

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Autores principales:	Veronica Coppersmith, Sarah Hudgins, Jill Stoltzfus, Holly Stankewicz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0d6dd1fafb0e457682a6c0936f963267
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spelling	oai:doaj.org-article:0d6dd1fafb0e457682a6c0936f9632672021-12-02T18:18:44ZThe use of N-acetylcysteine in the prevention of hangover: a randomized trial10.1038/s41598-021-92676-02045-2322https://doaj.org/article/0d6dd1fafb0e457682a6c0936f9632672021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92676-0https://doaj.org/toc/2045-2322Abstract Hangovers resulting from alcohol intoxication can lead to adverse effects ranging from generalized discomfort and work-related absenteeism to emergency department visits from patients seeking symptomatic care. The purpose of this study was to evaluate the efficacy of a low dose (600–1800 mg) of N-Acetylcysteine (NAC) vs placebo on mitigating hangover symptoms. This was a randomized, double-blinded, placebo controlled crossover study involving 49 volunteers who consumed beer to obtain a breath alcohol content (BrAC) of 0.1 g/210L. The participants met on two separate occasions at which time they were given either NAC or placebo capsules. Opposing treatments were administered during the second encounter. The morning after the participant’s intoxication and treatment, a Hangover Symptom Scale Questionnaire was administered to determine subjective changes in hangover symptoms. Data was analyzed by self-control, comparing the participant’s hangover symptom severity when using NAC compared to placebo. No significant difference was found in the general distribution of total hangover scores (P = .45) (NAC = 10; Placebo = 13). There was also no significant difference found in the general distribution of specific hangover symptoms. However, a significant difference was found in the general distribution of total hangover difference scores based on gender (P = .04) (Female − 3.5; Male 2), specifically for nausea (P = .05) and weakness (P = .03). Although no difference was found in the general hangover scale scores, the study was suggestive of gender specific susceptibility with female participants having improved hangover symptoms after NAC use.Veronica CoppersmithSarah HudginsJill StoltzfusHolly StankewiczNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Veronica Coppersmith Sarah Hudgins Jill Stoltzfus Holly Stankewicz The use of N-acetylcysteine in the prevention of hangover: a randomized trial
description	Abstract Hangovers resulting from alcohol intoxication can lead to adverse effects ranging from generalized discomfort and work-related absenteeism to emergency department visits from patients seeking symptomatic care. The purpose of this study was to evaluate the efficacy of a low dose (600–1800 mg) of N-Acetylcysteine (NAC) vs placebo on mitigating hangover symptoms. This was a randomized, double-blinded, placebo controlled crossover study involving 49 volunteers who consumed beer to obtain a breath alcohol content (BrAC) of 0.1 g/210L. The participants met on two separate occasions at which time they were given either NAC or placebo capsules. Opposing treatments were administered during the second encounter. The morning after the participant’s intoxication and treatment, a Hangover Symptom Scale Questionnaire was administered to determine subjective changes in hangover symptoms. Data was analyzed by self-control, comparing the participant’s hangover symptom severity when using NAC compared to placebo. No significant difference was found in the general distribution of total hangover scores (P = .45) (NAC = 10; Placebo = 13). There was also no significant difference found in the general distribution of specific hangover symptoms. However, a significant difference was found in the general distribution of total hangover difference scores based on gender (P = .04) (Female − 3.5; Male 2), specifically for nausea (P = .05) and weakness (P = .03). Although no difference was found in the general hangover scale scores, the study was suggestive of gender specific susceptibility with female participants having improved hangover symptoms after NAC use.
format	article
author	Veronica Coppersmith Sarah Hudgins Jill Stoltzfus Holly Stankewicz
author_facet	Veronica Coppersmith Sarah Hudgins Jill Stoltzfus Holly Stankewicz
author_sort	Veronica Coppersmith
title	The use of N-acetylcysteine in the prevention of hangover: a randomized trial
title_short	The use of N-acetylcysteine in the prevention of hangover: a randomized trial
title_full	The use of N-acetylcysteine in the prevention of hangover: a randomized trial
title_fullStr	The use of N-acetylcysteine in the prevention of hangover: a randomized trial
title_full_unstemmed	The use of N-acetylcysteine in the prevention of hangover: a randomized trial
title_sort	use of n-acetylcysteine in the prevention of hangover: a randomized trial
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0d6dd1fafb0e457682a6c0936f963267
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The use of N-acetylcysteine in the prevention of hangover: a randomized trial

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