Ceftriaxone-induced Encephalopathy: A Pharmacokinetic Approach

We report a case of ceftriaxone-induced encephalopathy correlated with high cerebrospinal fluid concentration. Neurotoxicity of cephalosporin is increasingly reported, especially regarding fourth-generation cephalosporins. The factors influencing the corticospinal fluid (CSF) concentration are plasm...

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Autores principales:	Laurent Jadot, Aurelie Judong, Jean-Luc Canivet, Noel Lorenzo Villalba, Pierre Damas
Formato:	article
Lenguaje:	EN
Publicado:	SMC MEDIA SRL 2021
Materias:	encephalopathy ceftriaxone cerebrospinal fluid (csf) concentration Medicine R
Acceso en línea:	https://doaj.org/article/0d6f189d1ccd4153a781aa2608e0200a
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spelling	oai:doaj.org-article:0d6f189d1ccd4153a781aa2608e0200a2021-11-09T11:22:41ZCeftriaxone-induced Encephalopathy: A Pharmacokinetic Approach2284-259410.12890/2021_003011https://doaj.org/article/0d6f189d1ccd4153a781aa2608e0200a2021-11-01T00:00:00Zhttps://www.ejcrim.com/index.php/EJCRIM/article/view/3011https://doaj.org/toc/2284-2594We report a case of ceftriaxone-induced encephalopathy correlated with high cerebrospinal fluid concentration. Neurotoxicity of cephalosporin is increasingly reported, especially regarding fourth-generation cephalosporins. The factors influencing the corticospinal fluid (CSF) concentration are plasma concentration, liposolubility, ionization, molecular weight, protein binding and efflux. In our patient, high levels of ceftriaxone (27.9 mg/l) were found in the CSF. β-lactam associated neurotoxicity is mainly related to similarities between GABA and β-lactam ring. Because of disparate CSF/plasma ratio and blood-brain barrier efflux among patients, plasmatic drug monitoring probably cannot be used as a surrogate of CSF concentration. This is, as we know, the first case of described ceftriaxone-induced encephalopathy associated with an objective excessive cerebrospinal concentration.Laurent JadotAurelie JudongJean-Luc CanivetNoel Lorenzo VillalbaPierre DamasSMC MEDIA SRLarticleencephalopathyceftriaxonecerebrospinal fluid (csf) concentrationMedicineRENEuropean Journal of Case Reports in Internal Medicine (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	encephalopathy ceftriaxone cerebrospinal fluid (csf) concentration Medicine R
spellingShingle	encephalopathy ceftriaxone cerebrospinal fluid (csf) concentration Medicine R Laurent Jadot Aurelie Judong Jean-Luc Canivet Noel Lorenzo Villalba Pierre Damas Ceftriaxone-induced Encephalopathy: A Pharmacokinetic Approach
description	We report a case of ceftriaxone-induced encephalopathy correlated with high cerebrospinal fluid concentration. Neurotoxicity of cephalosporin is increasingly reported, especially regarding fourth-generation cephalosporins. The factors influencing the corticospinal fluid (CSF) concentration are plasma concentration, liposolubility, ionization, molecular weight, protein binding and efflux. In our patient, high levels of ceftriaxone (27.9 mg/l) were found in the CSF. β-lactam associated neurotoxicity is mainly related to similarities between GABA and β-lactam ring. Because of disparate CSF/plasma ratio and blood-brain barrier efflux among patients, plasmatic drug monitoring probably cannot be used as a surrogate of CSF concentration. This is, as we know, the first case of described ceftriaxone-induced encephalopathy associated with an objective excessive cerebrospinal concentration.
format	article
author	Laurent Jadot Aurelie Judong Jean-Luc Canivet Noel Lorenzo Villalba Pierre Damas
author_facet	Laurent Jadot Aurelie Judong Jean-Luc Canivet Noel Lorenzo Villalba Pierre Damas
author_sort	Laurent Jadot
title	Ceftriaxone-induced Encephalopathy: A Pharmacokinetic Approach
title_short	Ceftriaxone-induced Encephalopathy: A Pharmacokinetic Approach
title_full	Ceftriaxone-induced Encephalopathy: A Pharmacokinetic Approach
title_fullStr	Ceftriaxone-induced Encephalopathy: A Pharmacokinetic Approach
title_full_unstemmed	Ceftriaxone-induced Encephalopathy: A Pharmacokinetic Approach
title_sort	ceftriaxone-induced encephalopathy: a pharmacokinetic approach
publisher	SMC MEDIA SRL
publishDate	2021
url	https://doaj.org/article/0d6f189d1ccd4153a781aa2608e0200a
work_keys_str_mv	AT laurentjadot ceftriaxoneinducedencephalopathyapharmacokineticapproach AT aureliejudong ceftriaxoneinducedencephalopathyapharmacokineticapproach AT jeanluccanivet ceftriaxoneinducedencephalopathyapharmacokineticapproach AT noellorenzovillalba ceftriaxoneinducedencephalopathyapharmacokineticapproach AT pierredamas ceftriaxoneinducedencephalopathyapharmacokineticapproach
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Ceftriaxone-induced Encephalopathy: A Pharmacokinetic Approach

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