Neo-actinomycins A and B, natural actinomycins bearing the 5H-oxazolo[4,5-b]phenoxazine chromophore, from the marine-derived Streptomyces sp. IMB094

Abstract Neo-actinomycins A and B (1 and 2), two new natural actinomycins featuring an unprecedented tetracyclic 5H-oxazolo[4,5-b]phenoxazine chromophore, were isolated from the marine-derived actinomycete Streptomyces sp. IMB094. Their structures were elucidated by spectroscopic analyses. The prese...

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Autores principales:	Qiang Wang, Yixuan Zhang, Mian Wang, Yi Tan, Xinxin Hu, Hongwei He, Chunling Xiao, Xuefu You, Yiguang Wang, Maoluo Gan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0d743bb8f4d4472aada1a9632074a335
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spelling	oai:doaj.org-article:0d743bb8f4d4472aada1a9632074a3352021-12-02T11:40:21ZNeo-actinomycins A and B, natural actinomycins bearing the 5H-oxazolo[4,5-b]phenoxazine chromophore, from the marine-derived Streptomyces sp. IMB09410.1038/s41598-017-03769-82045-2322https://doaj.org/article/0d743bb8f4d4472aada1a9632074a3352017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03769-8https://doaj.org/toc/2045-2322Abstract Neo-actinomycins A and B (1 and 2), two new natural actinomycins featuring an unprecedented tetracyclic 5H-oxazolo[4,5-b]phenoxazine chromophore, were isolated from the marine-derived actinomycete Streptomyces sp. IMB094. Their structures were elucidated by spectroscopic analyses. The presence of this ring system was proposed to originate from a condensation between actinomycin D (3) with α-ketoglutarate and pyruvate, respectively. Compound 1 showed potent cytotoxic activities against human cancer HCT116 and A549 cell lines in the nanomolar range (IC50: 38.7 and 65.8 nM, respectively) and moderate antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) strains.Qiang WangYixuan ZhangMian WangYi TanXinxin HuHongwei HeChunling XiaoXuefu YouYiguang WangMaoluo GanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qiang Wang Yixuan Zhang Mian Wang Yi Tan Xinxin Hu Hongwei He Chunling Xiao Xuefu You Yiguang Wang Maoluo Gan Neo-actinomycins A and B, natural actinomycins bearing the 5H-oxazolo[4,5-b]phenoxazine chromophore, from the marine-derived Streptomyces sp. IMB094
description	Abstract Neo-actinomycins A and B (1 and 2), two new natural actinomycins featuring an unprecedented tetracyclic 5H-oxazolo[4,5-b]phenoxazine chromophore, were isolated from the marine-derived actinomycete Streptomyces sp. IMB094. Their structures were elucidated by spectroscopic analyses. The presence of this ring system was proposed to originate from a condensation between actinomycin D (3) with α-ketoglutarate and pyruvate, respectively. Compound 1 showed potent cytotoxic activities against human cancer HCT116 and A549 cell lines in the nanomolar range (IC50: 38.7 and 65.8 nM, respectively) and moderate antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) strains.
format	article
author	Qiang Wang Yixuan Zhang Mian Wang Yi Tan Xinxin Hu Hongwei He Chunling Xiao Xuefu You Yiguang Wang Maoluo Gan
author_facet	Qiang Wang Yixuan Zhang Mian Wang Yi Tan Xinxin Hu Hongwei He Chunling Xiao Xuefu You Yiguang Wang Maoluo Gan
author_sort	Qiang Wang
title	Neo-actinomycins A and B, natural actinomycins bearing the 5H-oxazolo[4,5-b]phenoxazine chromophore, from the marine-derived Streptomyces sp. IMB094
title_short	Neo-actinomycins A and B, natural actinomycins bearing the 5H-oxazolo[4,5-b]phenoxazine chromophore, from the marine-derived Streptomyces sp. IMB094
title_full	Neo-actinomycins A and B, natural actinomycins bearing the 5H-oxazolo[4,5-b]phenoxazine chromophore, from the marine-derived Streptomyces sp. IMB094
title_fullStr	Neo-actinomycins A and B, natural actinomycins bearing the 5H-oxazolo[4,5-b]phenoxazine chromophore, from the marine-derived Streptomyces sp. IMB094
title_full_unstemmed	Neo-actinomycins A and B, natural actinomycins bearing the 5H-oxazolo[4,5-b]phenoxazine chromophore, from the marine-derived Streptomyces sp. IMB094
title_sort	neo-actinomycins a and b, natural actinomycins bearing the 5h-oxazolo[4,5-b]phenoxazine chromophore, from the marine-derived streptomyces sp. imb094
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0d743bb8f4d4472aada1a9632074a335
work_keys_str_mv	AT qiangwang neoactinomycinsaandbnaturalactinomycinsbearingthe5hoxazolo45bphenoxazinechromophorefromthemarinederivedstreptomycesspimb094 AT yixuanzhang neoactinomycinsaandbnaturalactinomycinsbearingthe5hoxazolo45bphenoxazinechromophorefromthemarinederivedstreptomycesspimb094 AT mianwang neoactinomycinsaandbnaturalactinomycinsbearingthe5hoxazolo45bphenoxazinechromophorefromthemarinederivedstreptomycesspimb094 AT yitan neoactinomycinsaandbnaturalactinomycinsbearingthe5hoxazolo45bphenoxazinechromophorefromthemarinederivedstreptomycesspimb094 AT xinxinhu neoactinomycinsaandbnaturalactinomycinsbearingthe5hoxazolo45bphenoxazinechromophorefromthemarinederivedstreptomycesspimb094 AT hongweihe neoactinomycinsaandbnaturalactinomycinsbearingthe5hoxazolo45bphenoxazinechromophorefromthemarinederivedstreptomycesspimb094 AT chunlingxiao neoactinomycinsaandbnaturalactinomycinsbearingthe5hoxazolo45bphenoxazinechromophorefromthemarinederivedstreptomycesspimb094 AT xuefuyou neoactinomycinsaandbnaturalactinomycinsbearingthe5hoxazolo45bphenoxazinechromophorefromthemarinederivedstreptomycesspimb094 AT yiguangwang neoactinomycinsaandbnaturalactinomycinsbearingthe5hoxazolo45bphenoxazinechromophorefromthemarinederivedstreptomycesspimb094 AT maoluogan neoactinomycinsaandbnaturalactinomycinsbearingthe5hoxazolo45bphenoxazinechromophorefromthemarinederivedstreptomycesspimb094
_version_	1718395624168095744

Neo-actinomycins A and B, natural actinomycins bearing the 5H-oxazolo[4,5-b]phenoxazine chromophore, from the marine-derived Streptomyces sp. IMB094

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