Association of HLA Alleles and HLA Haplotypes with Psoriasis, Psoriatic Arthritis and Disease Severity in a Miscegenated Population

Flavia de Freire Cassia,1 Juliana Fernandes Cardoso,2 Luiz Cristovao Porto,3 Marcia Ramos-e-Silva,1 Sueli Carneiro4 1Sector of Dermatology, Post-Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; 2Histocompatibi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Cassia FF, Cardoso JF, Porto LC, Ramos-e-Silva M, Carneiro S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	psoriasis psoriatic arthritis hla population study Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/0d74be357a5f428a8bedb56c10cc9e47
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0d74be357a5f428a8bedb56c10cc9e47
record_format	dspace
spelling	oai:doaj.org-article:0d74be357a5f428a8bedb56c10cc9e472021-12-02T16:58:09ZAssociation of HLA Alleles and HLA Haplotypes with Psoriasis, Psoriatic Arthritis and Disease Severity in a Miscegenated Population2230-326Xhttps://doaj.org/article/0d74be357a5f428a8bedb56c10cc9e472021-05-01T00:00:00Zhttps://www.dovepress.com/association-of-hla-alleles-and-hla-haplotypes-with-psoriasis-psoriatic-peer-reviewed-fulltext-article-PTThttps://doaj.org/toc/2230-326XFlavia de Freire Cassia,1 Juliana Fernandes Cardoso,2 Luiz Cristovao Porto,3 Marcia Ramos-e-Silva,1 Sueli Carneiro4 1Sector of Dermatology, Post-Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; 2Histocompatibility Section, Special Techniques Laboratory, Albert Einstein Israelite Hospital- HIAE, São Paulo, Brazil; 3Histocompatibility and Cryopreservation Laboratory, Rio de Janeiro State University, Rio de Janeiro, Brazil; 4Sector of Dermatology, University Hospital and School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, BrazilCorrespondence: Flavia de Freire CassiaSector of Dermatology, Post-Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rua Jardim Botanico, 700 /416, Rio de Janeiro, 22461-000, BrazilTel +55 21999640406Email flaviafcassia@gmail.comBackground: The study of HLA classes I and II in Brazilian psoriasis patients may contribute to a better understanding of their association with the disease.Objective: To describe HLA classes I and II of Brazilian patients with psoriasis, with or without arthritis, compare them to controls and correlate HLA markers with epidemiological and evolutional aspects of psoriasis.Methods: A total of 55 patients with more than 5 years of psoriasis, with or without arthritis, answered a questionnaire on ethnic background and disease severity. A total of 134 bone marrow donors were controls. HLA class I and II genotyping was determined by PCR-SSP.Results: Mean age was 42.4 years; 23 women and 32 men. HLA-B57 was present in 23.6% patients and in 7.5% controls (p=0.00200, OR= 3.8381), and HLA-C06 in 29.1% patients and in 16.4% controls (p= 0.04832, OR=2.0886). HLA-B57 and HLA-C18 were significantly present in patients with arthritis (p=0.00104, OR=6.6769 and p=0.00269, OR=16.50, respectively). HLA-B57 was significantly present in patients with history of erythroderma (p=0.00548, OR= 5.1059), as was HLA-C06 (p=0.02158, OR=3.0545). HLA-B57 was also frequent in patients with history of hospital internment due to psoriasis (p= 0.00094, OR=7.8909) and in the ones with history of systemic treatment for psoriasis (p= 0.00011, OR= 5.3733). Haplotype HLA-A02 B57 C06 DRB107DQB103 was the most common among the patients (p= 0.00069, OR= 3.528).Conclusion: HLA-B57 and HLA-C06 were significantly increased in the patients indicating risk for psoriasis. HLA-B57 remained high in patients with history of erythroderma, hospital internment, systemic treatment, and psoriatic arthritis, showing association with disease severity. HLA-C18 was significantly high only in patients with psoriatic arthritis. HLA-B57 and HLA-C06 and haplotype HLA-A02B57Cw06DRB107 DQB103 seen in this study were already described before, associated with psoriasis. HLA-Cw18 was not described in other populations in association with psoriasis.Keywords: psoriasis, psoriatic arthritis, HLA, population studyCassia FFCardoso JFPorto LCRamos-e-Silva MCarneiro SDove Medical Pressarticlepsoriasispsoriatic arthritishlapopulation studyDermatologyRL1-803ENPsoriasis: Targets and Therapy, Vol Volume 11, Pp 41-51 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	psoriasis psoriatic arthritis hla population study Dermatology RL1-803
spellingShingle	psoriasis psoriatic arthritis hla population study Dermatology RL1-803 Cassia FF Cardoso JF Porto LC Ramos-e-Silva M Carneiro S Association of HLA Alleles and HLA Haplotypes with Psoriasis, Psoriatic Arthritis and Disease Severity in a Miscegenated Population
description	Flavia de Freire Cassia,1 Juliana Fernandes Cardoso,2 Luiz Cristovao Porto,3 Marcia Ramos-e-Silva,1 Sueli Carneiro4 1Sector of Dermatology, Post-Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; 2Histocompatibility Section, Special Techniques Laboratory, Albert Einstein Israelite Hospital- HIAE, São Paulo, Brazil; 3Histocompatibility and Cryopreservation Laboratory, Rio de Janeiro State University, Rio de Janeiro, Brazil; 4Sector of Dermatology, University Hospital and School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, BrazilCorrespondence: Flavia de Freire CassiaSector of Dermatology, Post-Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rua Jardim Botanico, 700 /416, Rio de Janeiro, 22461-000, BrazilTel +55 21999640406Email flaviafcassia@gmail.comBackground: The study of HLA classes I and II in Brazilian psoriasis patients may contribute to a better understanding of their association with the disease.Objective: To describe HLA classes I and II of Brazilian patients with psoriasis, with or without arthritis, compare them to controls and correlate HLA markers with epidemiological and evolutional aspects of psoriasis.Methods: A total of 55 patients with more than 5 years of psoriasis, with or without arthritis, answered a questionnaire on ethnic background and disease severity. A total of 134 bone marrow donors were controls. HLA class I and II genotyping was determined by PCR-SSP.Results: Mean age was 42.4 years; 23 women and 32 men. HLA-B57 was present in 23.6% patients and in 7.5% controls (p=0.00200, OR= 3.8381), and HLA-C06 in 29.1% patients and in 16.4% controls (p= 0.04832, OR=2.0886). HLA-B57 and HLA-C18 were significantly present in patients with arthritis (p=0.00104, OR=6.6769 and p=0.00269, OR=16.50, respectively). HLA-B57 was significantly present in patients with history of erythroderma (p=0.00548, OR= 5.1059), as was HLA-C06 (p=0.02158, OR=3.0545). HLA-B57 was also frequent in patients with history of hospital internment due to psoriasis (p= 0.00094, OR=7.8909) and in the ones with history of systemic treatment for psoriasis (p= 0.00011, OR= 5.3733). Haplotype HLA-A02 B57 C06 DRB107DQB103 was the most common among the patients (p= 0.00069, OR= 3.528).Conclusion: HLA-B57 and HLA-C06 were significantly increased in the patients indicating risk for psoriasis. HLA-B57 remained high in patients with history of erythroderma, hospital internment, systemic treatment, and psoriatic arthritis, showing association with disease severity. HLA-C18 was significantly high only in patients with psoriatic arthritis. HLA-B57 and HLA-C06 and haplotype HLA-A02B57Cw06DRB107 DQB103 seen in this study were already described before, associated with psoriasis. HLA-Cw18 was not described in other populations in association with psoriasis.Keywords: psoriasis, psoriatic arthritis, HLA, population study
format	article
author	Cassia FF Cardoso JF Porto LC Ramos-e-Silva M Carneiro S
author_facet	Cassia FF Cardoso JF Porto LC Ramos-e-Silva M Carneiro S
author_sort	Cassia FF
title	Association of HLA Alleles and HLA Haplotypes with Psoriasis, Psoriatic Arthritis and Disease Severity in a Miscegenated Population
title_short	Association of HLA Alleles and HLA Haplotypes with Psoriasis, Psoriatic Arthritis and Disease Severity in a Miscegenated Population
title_full	Association of HLA Alleles and HLA Haplotypes with Psoriasis, Psoriatic Arthritis and Disease Severity in a Miscegenated Population
title_fullStr	Association of HLA Alleles and HLA Haplotypes with Psoriasis, Psoriatic Arthritis and Disease Severity in a Miscegenated Population
title_full_unstemmed	Association of HLA Alleles and HLA Haplotypes with Psoriasis, Psoriatic Arthritis and Disease Severity in a Miscegenated Population
title_sort	association of hla alleles and hla haplotypes with psoriasis, psoriatic arthritis and disease severity in a miscegenated population
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/0d74be357a5f428a8bedb56c10cc9e47
work_keys_str_mv	AT cassiaff associationofhlaallelesandhlahaplotypeswithpsoriasispsoriaticarthritisanddiseaseseverityinamiscegenatedpopulation AT cardosojf associationofhlaallelesandhlahaplotypeswithpsoriasispsoriaticarthritisanddiseaseseverityinamiscegenatedpopulation AT portolc associationofhlaallelesandhlahaplotypeswithpsoriasispsoriaticarthritisanddiseaseseverityinamiscegenatedpopulation AT ramosesilvam associationofhlaallelesandhlahaplotypeswithpsoriasispsoriaticarthritisanddiseaseseverityinamiscegenatedpopulation AT carneiros associationofhlaallelesandhlahaplotypeswithpsoriasispsoriaticarthritisanddiseaseseverityinamiscegenatedpopulation
_version_	1718382370150678528

Association of HLA Alleles and HLA Haplotypes with Psoriasis, Psoriatic Arthritis and Disease Severity in a Miscegenated Population

Ejemplares similares