Obstructive sleep apnoea and 12-month weight loss in adults with class 3 obesity attending a multidisciplinary weight management program

Abstract Background Although there is a strong association between obesity and obstructive sleep apnoea (OSA), the effects of OSA and CPAP therapy on weight loss are less well known. The aim of this study in adults with class 3 obesity attending a multidisciplinary weight management program was to a...

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Autores principales:	Sophie Kobuch, Fiona Tsang, Ritesh Chimoriya, Daniel Gossayn, Sarah O’Brien, Javeria Jamal, Leon Laks, Abd Tahrani, Nic Kormas, Milan K Piya
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Obstructive sleep apnoea Continuous positive airway pressure (CPAP) Weight management Class 3 obesity Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/0d7beb9236dc4b8188a4be0cfb120eb9
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spelling	oai:doaj.org-article:0d7beb9236dc4b8188a4be0cfb120eb92021-11-14T12:05:29ZObstructive sleep apnoea and 12-month weight loss in adults with class 3 obesity attending a multidisciplinary weight management program10.1186/s12902-021-00887-31472-6823https://doaj.org/article/0d7beb9236dc4b8188a4be0cfb120eb92021-11-01T00:00:00Zhttps://doi.org/10.1186/s12902-021-00887-3https://doaj.org/toc/1472-6823Abstract Background Although there is a strong association between obesity and obstructive sleep apnoea (OSA), the effects of OSA and CPAP therapy on weight loss are less well known. The aim of this study in adults with class 3 obesity attending a multidisciplinary weight management program was to assess the relationship between OSA and CPAP usage, and 12-month weight change. Methods A retrospective cohort study of all patients commencing an intensive multidisciplinary publicly funded weight management program in Sydney, Australia, between March 2018 and March 2019. OSA was diagnosed using laboratory overnight sleep studies. Demographic and clinical data, and use of CPAP therapy was collected at baseline and 12 months. CPAP use was confirmed if used ≥4 h on average per night on download. Results Of the 178 patients who joined the program, 111 (62.4 %) completed 12 months in the program. At baseline, 63.1 % (n=70) of patients had OSA, of whom 54.3 % (n=38) were using CPAP. The non-OSA group had more females compared to the OSA with CPAP group and OSA without CPAP group (90.2 % vs. 57.9 % and 62.5 %, respectively; p=0.003), but there were no significant baseline differences in BMI (50.4±9.3 vs. 52.1±8.7 and 50.3±9.5 kg/m2, respectively; p=0.636). There was significant weight loss across all three groups at 12 months. However, there were no statistically significant differences across groups in the percentage of body weight loss (OSA with CPAP: 6.3±5.6 %, OSA without CPAP: 6.8±6.9 %, non-OSA: 7.2±6.5 %; p=0.844), or the proportion of patients who achieved ≥5 % body weight loss (OSA with CPAP: 57.9 %, OSA without CPAP: 59.4 %, non-OSA: 65.9 %; p=0.743). In patients with T2DM, there was a significant reduction in HbA1c from baseline to 12 months (7.8±1.7 % to 7.3±1.4 %, p=0.03), with no difference between groups (p=0.997). Conclusions This multidisciplinary weight management program resulted in significant weight loss at 12 months, regardless of OSA diagnosis or CPAP use in adults with class 3 obesity. Larger studies are needed to further investigate the effects of severity of OSA status and CPAP use in weight management programs. Until completed, this study suggests that the focus should remain on implementing lifestyle changes and weight management regardless of OSA status.Sophie KobuchFiona TsangRitesh ChimoriyaDaniel GossaynSarah O’BrienJaveria JamalLeon LaksAbd TahraniNic KormasMilan K PiyaBMCarticleObstructive sleep apnoeaContinuous positive airway pressure (CPAP)Weight managementClass 3 obesityDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENBMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Obstructive sleep apnoea Continuous positive airway pressure (CPAP) Weight management Class 3 obesity Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	Obstructive sleep apnoea Continuous positive airway pressure (CPAP) Weight management Class 3 obesity Diseases of the endocrine glands. Clinical endocrinology RC648-665 Sophie Kobuch Fiona Tsang Ritesh Chimoriya Daniel Gossayn Sarah O’Brien Javeria Jamal Leon Laks Abd Tahrani Nic Kormas Milan K Piya Obstructive sleep apnoea and 12-month weight loss in adults with class 3 obesity attending a multidisciplinary weight management program
description	Abstract Background Although there is a strong association between obesity and obstructive sleep apnoea (OSA), the effects of OSA and CPAP therapy on weight loss are less well known. The aim of this study in adults with class 3 obesity attending a multidisciplinary weight management program was to assess the relationship between OSA and CPAP usage, and 12-month weight change. Methods A retrospective cohort study of all patients commencing an intensive multidisciplinary publicly funded weight management program in Sydney, Australia, between March 2018 and March 2019. OSA was diagnosed using laboratory overnight sleep studies. Demographic and clinical data, and use of CPAP therapy was collected at baseline and 12 months. CPAP use was confirmed if used ≥4 h on average per night on download. Results Of the 178 patients who joined the program, 111 (62.4 %) completed 12 months in the program. At baseline, 63.1 % (n=70) of patients had OSA, of whom 54.3 % (n=38) were using CPAP. The non-OSA group had more females compared to the OSA with CPAP group and OSA without CPAP group (90.2 % vs. 57.9 % and 62.5 %, respectively; p=0.003), but there were no significant baseline differences in BMI (50.4±9.3 vs. 52.1±8.7 and 50.3±9.5 kg/m2, respectively; p=0.636). There was significant weight loss across all three groups at 12 months. However, there were no statistically significant differences across groups in the percentage of body weight loss (OSA with CPAP: 6.3±5.6 %, OSA without CPAP: 6.8±6.9 %, non-OSA: 7.2±6.5 %; p=0.844), or the proportion of patients who achieved ≥5 % body weight loss (OSA with CPAP: 57.9 %, OSA without CPAP: 59.4 %, non-OSA: 65.9 %; p=0.743). In patients with T2DM, there was a significant reduction in HbA1c from baseline to 12 months (7.8±1.7 % to 7.3±1.4 %, p=0.03), with no difference between groups (p=0.997). Conclusions This multidisciplinary weight management program resulted in significant weight loss at 12 months, regardless of OSA diagnosis or CPAP use in adults with class 3 obesity. Larger studies are needed to further investigate the effects of severity of OSA status and CPAP use in weight management programs. Until completed, this study suggests that the focus should remain on implementing lifestyle changes and weight management regardless of OSA status.
format	article
author	Sophie Kobuch Fiona Tsang Ritesh Chimoriya Daniel Gossayn Sarah O’Brien Javeria Jamal Leon Laks Abd Tahrani Nic Kormas Milan K Piya
author_facet	Sophie Kobuch Fiona Tsang Ritesh Chimoriya Daniel Gossayn Sarah O’Brien Javeria Jamal Leon Laks Abd Tahrani Nic Kormas Milan K Piya
author_sort	Sophie Kobuch
title	Obstructive sleep apnoea and 12-month weight loss in adults with class 3 obesity attending a multidisciplinary weight management program
title_short	Obstructive sleep apnoea and 12-month weight loss in adults with class 3 obesity attending a multidisciplinary weight management program
title_full	Obstructive sleep apnoea and 12-month weight loss in adults with class 3 obesity attending a multidisciplinary weight management program
title_fullStr	Obstructive sleep apnoea and 12-month weight loss in adults with class 3 obesity attending a multidisciplinary weight management program
title_full_unstemmed	Obstructive sleep apnoea and 12-month weight loss in adults with class 3 obesity attending a multidisciplinary weight management program
title_sort	obstructive sleep apnoea and 12-month weight loss in adults with class 3 obesity attending a multidisciplinary weight management program
publisher	BMC
publishDate	2021
url	https://doaj.org/article/0d7beb9236dc4b8188a4be0cfb120eb9
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Obstructive sleep apnoea and 12-month weight loss in adults with class 3 obesity attending a multidisciplinary weight management program

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