Development of an Experimental Dentifrice with Hydroxyapatite Nanoparticles and High Fluoride Concentration to Manage Root Dentin Demineralization

Aila Maria Cipriano Leal,1 Marcus Vinícius Beserra dos Santos,2 Edson Cavalcanti da Silva Filho,2 André Luis Menezes de Carvalho,3 Cinthia Pereira Machado Tabchoury,4 Glauber Campos Vale1 1Department of Restorative Dentistry, Federal University of Piaui, Teresina, Piau&iacu...

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Autores principales:	Leal AMC, Beserra dos Santos MV, da Silva Filho EC, Menezes de Carvalho AL, Tabchoury CPM, Vale GC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	material development dentin dentifrice fluoride nanohydroxyapatite Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0d7eb7634b9a42a48679118572cadd90
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spelling	oai:doaj.org-article:0d7eb7634b9a42a48679118572cadd902021-12-02T10:02:39ZDevelopment of an Experimental Dentifrice with Hydroxyapatite Nanoparticles and High Fluoride Concentration to Manage Root Dentin Demineralization1178-2013https://doaj.org/article/0d7eb7634b9a42a48679118572cadd902020-10-01T00:00:00Zhttps://www.dovepress.com/development-of-an-experimental-dentifrice-with-hydroxyapatite-nanopart-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Aila Maria Cipriano Leal,1 Marcus Vinícius Beserra dos Santos,2 Edson Cavalcanti da Silva Filho,2 André Luis Menezes de Carvalho,3 Cinthia Pereira Machado Tabchoury,4 Glauber Campos Vale1 1Department of Restorative Dentistry, Federal University of Piaui, Teresina, Piauí, Brazil; 2Interdisciplinary Laboratory of Advanced Materials, Federal University of Piaui, Teresina, Piauí, Brazil; 3Dermopharmacy Laboratory, Federal University of Piaui, Teresina, Piauí, Brazil; 4Departament of Physiological Sciences, Campinas State University, Piracicaba, São Paulo, BrazilCorrespondence: Glauber Campos ValeDepartment of Restorative Dentistry, Federal University of Piaui, Campus Universitário Ministro Petrônio Portella – SG 10 Bairro Ininga, CEP: 64049-550, Teresina, Piauí, BrazilTel +55 (86) 999912-9200Email glauber@ufpi.edu.brBackground: High-fluoride dentifrice is used to manage root caries, but there is no evidence whether its association with nanohydroxyapatite could provide an additional protection for root caries. Therefore, this study aimed to develop and evaluate the effect of an experimental dentifrice with high fluoride (F−) concentration and nanohydroxyapatite (nano-HA) on root dentin demineralization.Materials and Methods: After formulation of dentifrices, root dentin specimens were randomly assigned to six groups (n = 10) using different dentifrice treatments: placebo; nano-HA without F−; 1,100 μg F−/g; 1,100 μg F−/g + nano-HA; 5,000 μg F−/g; and 5,000 μg F−/g + nano-HA. A pH cycling model was performed for 10 days, in which treatments were performed twice a day. After that period, the longitudinal hardness was evaluated and the area of demineralization (ΔS) was calculated. The formulated dentifrices were evaluated for primary stability, cytotoxicity, and other technical parameters. Two-way ANOVA and Tukey’s test with p set at 5% were used for data analysis.Results: The experimental dentifrices were stable and had no cytotoxicity. Regarding dentin demineralization, the placebo group significantly increased ΔS compared to all other treatment groups (p< 0.001). The dentifrices containing 5,000 μg F−/g, regardless of the presence of nano-HA, led to a smaller lesion area in relation to the other treatments (p< 0.001).Conclusion: The findings of this study suggest that nano-HA reduced dentin demineralization, and dentifrice with 5,000 μg F−/g dentifrices, regardless of the presence of nano-HA, showed a greater reduction in root dentin demineralization.Keywords: material development, dentin, dentifrice, fluoride, nanohydroxyapatiteLeal AMCBeserra dos Santos MVda Silva Filho ECMenezes de Carvalho ALTabchoury CPMVale GCDove Medical Pressarticlematerial developmentdentindentifricefluoridenanohydroxyapatiteMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 7469-7479 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	material development dentin dentifrice fluoride nanohydroxyapatite Medicine (General) R5-920
spellingShingle	material development dentin dentifrice fluoride nanohydroxyapatite Medicine (General) R5-920 Leal AMC Beserra dos Santos MV da Silva Filho EC Menezes de Carvalho AL Tabchoury CPM Vale GC Development of an Experimental Dentifrice with Hydroxyapatite Nanoparticles and High Fluoride Concentration to Manage Root Dentin Demineralization
description	Aila Maria Cipriano Leal,1 Marcus Vinícius Beserra dos Santos,2 Edson Cavalcanti da Silva Filho,2 André Luis Menezes de Carvalho,3 Cinthia Pereira Machado Tabchoury,4 Glauber Campos Vale1 1Department of Restorative Dentistry, Federal University of Piaui, Teresina, Piauí, Brazil; 2Interdisciplinary Laboratory of Advanced Materials, Federal University of Piaui, Teresina, Piauí, Brazil; 3Dermopharmacy Laboratory, Federal University of Piaui, Teresina, Piauí, Brazil; 4Departament of Physiological Sciences, Campinas State University, Piracicaba, São Paulo, BrazilCorrespondence: Glauber Campos ValeDepartment of Restorative Dentistry, Federal University of Piaui, Campus Universitário Ministro Petrônio Portella – SG 10 Bairro Ininga, CEP: 64049-550, Teresina, Piauí, BrazilTel +55 (86) 999912-9200Email glauber@ufpi.edu.brBackground: High-fluoride dentifrice is used to manage root caries, but there is no evidence whether its association with nanohydroxyapatite could provide an additional protection for root caries. Therefore, this study aimed to develop and evaluate the effect of an experimental dentifrice with high fluoride (F−) concentration and nanohydroxyapatite (nano-HA) on root dentin demineralization.Materials and Methods: After formulation of dentifrices, root dentin specimens were randomly assigned to six groups (n = 10) using different dentifrice treatments: placebo; nano-HA without F−; 1,100 μg F−/g; 1,100 μg F−/g + nano-HA; 5,000 μg F−/g; and 5,000 μg F−/g + nano-HA. A pH cycling model was performed for 10 days, in which treatments were performed twice a day. After that period, the longitudinal hardness was evaluated and the area of demineralization (ΔS) was calculated. The formulated dentifrices were evaluated for primary stability, cytotoxicity, and other technical parameters. Two-way ANOVA and Tukey’s test with p set at 5% were used for data analysis.Results: The experimental dentifrices were stable and had no cytotoxicity. Regarding dentin demineralization, the placebo group significantly increased ΔS compared to all other treatment groups (p< 0.001). The dentifrices containing 5,000 μg F−/g, regardless of the presence of nano-HA, led to a smaller lesion area in relation to the other treatments (p< 0.001).Conclusion: The findings of this study suggest that nano-HA reduced dentin demineralization, and dentifrice with 5,000 μg F−/g dentifrices, regardless of the presence of nano-HA, showed a greater reduction in root dentin demineralization.Keywords: material development, dentin, dentifrice, fluoride, nanohydroxyapatite
format	article
author	Leal AMC Beserra dos Santos MV da Silva Filho EC Menezes de Carvalho AL Tabchoury CPM Vale GC
author_facet	Leal AMC Beserra dos Santos MV da Silva Filho EC Menezes de Carvalho AL Tabchoury CPM Vale GC
author_sort	Leal AMC
title	Development of an Experimental Dentifrice with Hydroxyapatite Nanoparticles and High Fluoride Concentration to Manage Root Dentin Demineralization
title_short	Development of an Experimental Dentifrice with Hydroxyapatite Nanoparticles and High Fluoride Concentration to Manage Root Dentin Demineralization
title_full	Development of an Experimental Dentifrice with Hydroxyapatite Nanoparticles and High Fluoride Concentration to Manage Root Dentin Demineralization
title_fullStr	Development of an Experimental Dentifrice with Hydroxyapatite Nanoparticles and High Fluoride Concentration to Manage Root Dentin Demineralization
title_full_unstemmed	Development of an Experimental Dentifrice with Hydroxyapatite Nanoparticles and High Fluoride Concentration to Manage Root Dentin Demineralization
title_sort	development of an experimental dentifrice with hydroxyapatite nanoparticles and high fluoride concentration to manage root dentin demineralization
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/0d7eb7634b9a42a48679118572cadd90
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Development of an Experimental Dentifrice with Hydroxyapatite Nanoparticles and High Fluoride Concentration to Manage Root Dentin Demineralization

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