Studies on meropenem and cefixime metal ion complexes for antibacterial activity

Abstract Background The metal ion complexes of meropenem and cefixime with cadmium, silver, palladium, zinc, nickel, cobalt and copper were synthesized and characterized by UV, FTIR and H1-NMR spectrophotometry. The antibacterial effects of the complexes were studied using cup and plate method again...

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Autores principales:	Milind J. Umekar, Radheshyam T. Lohiya, Krishna R. Gupta, Nandkishore R. Kotagale, Neha S. Raut
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Meropenem Cefixime Metal ion complex Antibacterial MIC Resistance Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/0d7ee4f7fa054bdc8cdd1c3d0f5c7827
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spelling	oai:doaj.org-article:0d7ee4f7fa054bdc8cdd1c3d0f5c78272021-12-05T12:21:02ZStudies on meropenem and cefixime metal ion complexes for antibacterial activity10.1186/s43094-021-00379-02314-7253https://doaj.org/article/0d7ee4f7fa054bdc8cdd1c3d0f5c78272021-12-01T00:00:00Zhttps://doi.org/10.1186/s43094-021-00379-0https://doaj.org/toc/2314-7253Abstract Background The metal ion complexes of meropenem and cefixime with cadmium, silver, palladium, zinc, nickel, cobalt and copper were synthesized and characterized by UV, FTIR and H1-NMR spectrophotometry. The antibacterial effects of the complexes were studied using cup and plate method against S. aureus, B. subtilis, E. coli, P. aeruginosa and K. pneumoniae for normal and resistant strains of bacteria. The minimum inhibitory concentration of the metal ion complexes was determined by broth dilution method. Results UV spectroscopic studies suggested that meropenem ligand form complex with different metal ions and FTIR spectrum confirmed the proposed structure. Similarly, UV spectrum of cefixime metal ion complexes at λ max 202–295 nm and meropenem metal ion complexes at λ max 249–304 nm was observed in all the complexes. FTIR peaks for a proposed structure were observed in all the meropenem and cefixime metal ion, indicating the formation of complexes, and retained the functional groups of drugs. Meropenem as well as cefixime metal ion complexes exhibited more antibacterial activity against all the selected bacterial strains. Specifically, the lowest minimum inhibitory concentration against P. aeruginosa and K. pneumoniae was observed to be 100 and 150 μg/ml, respectively. Conclusion The present study concluded that the meropenem and cefixime metal complexes can exhibit the better treatment than individual drug on normal as well as resistant bacteria.Milind J. UmekarRadheshyam T. LohiyaKrishna R. GuptaNandkishore R. KotagaleNeha S. RautSpringerOpenarticleMeropenemCefiximeMetal ion complexAntibacterialMICResistanceTherapeutics. PharmacologyRM1-950Pharmacy and materia medicaRS1-441ENFuture Journal of Pharmaceutical Sciences, Vol 7, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Meropenem Cefixime Metal ion complex Antibacterial MIC Resistance Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441
spellingShingle	Meropenem Cefixime Metal ion complex Antibacterial MIC Resistance Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441 Milind J. Umekar Radheshyam T. Lohiya Krishna R. Gupta Nandkishore R. Kotagale Neha S. Raut Studies on meropenem and cefixime metal ion complexes for antibacterial activity
description	Abstract Background The metal ion complexes of meropenem and cefixime with cadmium, silver, palladium, zinc, nickel, cobalt and copper were synthesized and characterized by UV, FTIR and H1-NMR spectrophotometry. The antibacterial effects of the complexes were studied using cup and plate method against S. aureus, B. subtilis, E. coli, P. aeruginosa and K. pneumoniae for normal and resistant strains of bacteria. The minimum inhibitory concentration of the metal ion complexes was determined by broth dilution method. Results UV spectroscopic studies suggested that meropenem ligand form complex with different metal ions and FTIR spectrum confirmed the proposed structure. Similarly, UV spectrum of cefixime metal ion complexes at λ max 202–295 nm and meropenem metal ion complexes at λ max 249–304 nm was observed in all the complexes. FTIR peaks for a proposed structure were observed in all the meropenem and cefixime metal ion, indicating the formation of complexes, and retained the functional groups of drugs. Meropenem as well as cefixime metal ion complexes exhibited more antibacterial activity against all the selected bacterial strains. Specifically, the lowest minimum inhibitory concentration against P. aeruginosa and K. pneumoniae was observed to be 100 and 150 μg/ml, respectively. Conclusion The present study concluded that the meropenem and cefixime metal complexes can exhibit the better treatment than individual drug on normal as well as resistant bacteria.
format	article
author	Milind J. Umekar Radheshyam T. Lohiya Krishna R. Gupta Nandkishore R. Kotagale Neha S. Raut
author_facet	Milind J. Umekar Radheshyam T. Lohiya Krishna R. Gupta Nandkishore R. Kotagale Neha S. Raut
author_sort	Milind J. Umekar
title	Studies on meropenem and cefixime metal ion complexes for antibacterial activity
title_short	Studies on meropenem and cefixime metal ion complexes for antibacterial activity
title_full	Studies on meropenem and cefixime metal ion complexes for antibacterial activity
title_fullStr	Studies on meropenem and cefixime metal ion complexes for antibacterial activity
title_full_unstemmed	Studies on meropenem and cefixime metal ion complexes for antibacterial activity
title_sort	studies on meropenem and cefixime metal ion complexes for antibacterial activity
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/0d7ee4f7fa054bdc8cdd1c3d0f5c7827
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Studies on meropenem and cefixime metal ion complexes for antibacterial activity

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