Structural basis of actin monomer re-charging by cyclase-associated protein

Depolymerized ADP-actin monomers must be recharged with ATP for new rounds of filament assembly. Here the authors show that cyclase-associated protein (CAP) catalyzes actin nucleotide exchange in vivo and their CAP–actin complex structure reveals the molecular mechanism of CAP-mediated actin nucleot...

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Autores principales:	Tommi Kotila, Konstantin Kogan, Giray Enkavi, Siyang Guo, Ilpo Vattulainen, Bruce L. Goode, Pekka Lappalainen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0d7ef003bbce4a12bf5c7b11adc2fba6
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spelling	oai:doaj.org-article:0d7ef003bbce4a12bf5c7b11adc2fba62021-12-02T14:38:48ZStructural basis of actin monomer re-charging by cyclase-associated protein10.1038/s41467-018-04231-72041-1723https://doaj.org/article/0d7ef003bbce4a12bf5c7b11adc2fba62018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04231-7https://doaj.org/toc/2041-1723Depolymerized ADP-actin monomers must be recharged with ATP for new rounds of filament assembly. Here the authors show that cyclase-associated protein (CAP) catalyzes actin nucleotide exchange in vivo and their CAP–actin complex structure reveals the molecular mechanism of CAP-mediated actin nucleotide exchange.Tommi KotilaKonstantin KoganGiray EnkaviSiyang GuoIlpo VattulainenBruce L. GoodePekka LappalainenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tommi Kotila Konstantin Kogan Giray Enkavi Siyang Guo Ilpo Vattulainen Bruce L. Goode Pekka Lappalainen Structural basis of actin monomer re-charging by cyclase-associated protein
description	Depolymerized ADP-actin monomers must be recharged with ATP for new rounds of filament assembly. Here the authors show that cyclase-associated protein (CAP) catalyzes actin nucleotide exchange in vivo and their CAP–actin complex structure reveals the molecular mechanism of CAP-mediated actin nucleotide exchange.
format	article
author	Tommi Kotila Konstantin Kogan Giray Enkavi Siyang Guo Ilpo Vattulainen Bruce L. Goode Pekka Lappalainen
author_facet	Tommi Kotila Konstantin Kogan Giray Enkavi Siyang Guo Ilpo Vattulainen Bruce L. Goode Pekka Lappalainen
author_sort	Tommi Kotila
title	Structural basis of actin monomer re-charging by cyclase-associated protein
title_short	Structural basis of actin monomer re-charging by cyclase-associated protein
title_full	Structural basis of actin monomer re-charging by cyclase-associated protein
title_fullStr	Structural basis of actin monomer re-charging by cyclase-associated protein
title_full_unstemmed	Structural basis of actin monomer re-charging by cyclase-associated protein
title_sort	structural basis of actin monomer re-charging by cyclase-associated protein
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0d7ef003bbce4a12bf5c7b11adc2fba6
work_keys_str_mv	AT tommikotila structuralbasisofactinmonomerrechargingbycyclaseassociatedprotein AT konstantinkogan structuralbasisofactinmonomerrechargingbycyclaseassociatedprotein AT girayenkavi structuralbasisofactinmonomerrechargingbycyclaseassociatedprotein AT siyangguo structuralbasisofactinmonomerrechargingbycyclaseassociatedprotein AT ilpovattulainen structuralbasisofactinmonomerrechargingbycyclaseassociatedprotein AT brucelgoode structuralbasisofactinmonomerrechargingbycyclaseassociatedprotein AT pekkalappalainen structuralbasisofactinmonomerrechargingbycyclaseassociatedprotein
_version_	1718390813706158080

Structural basis of actin monomer re-charging by cyclase-associated protein

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