One-pot fabrication of Ag @Ag2O core–shell nanostructures for biosafe antimicrobial and antibiofilm applications

Abstract Microbial contamination is one of the major dreadful problems that raises hospitalization, morbidity and mortality rates globally, which subsequently obstructs socio-economic progress. The continuous misuse and overutilization of antibiotics participate mainly in the emergence of microbial...

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Autores principales:	Shaimaa Elyamny, Marwa Eltarahony, Marwa Abu-Serie, Marwa M. Nabil, Abd El-Hady B. Kashyout
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0d82c886d1ff46e0a8773f40e68cb6cf
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spelling	oai:doaj.org-article:0d82c886d1ff46e0a8773f40e68cb6cf2021-11-21T12:25:08ZOne-pot fabrication of Ag @Ag2O core–shell nanostructures for biosafe antimicrobial and antibiofilm applications10.1038/s41598-021-01687-42045-2322https://doaj.org/article/0d82c886d1ff46e0a8773f40e68cb6cf2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01687-4https://doaj.org/toc/2045-2322Abstract Microbial contamination is one of the major dreadful problems that raises hospitalization, morbidity and mortality rates globally, which subsequently obstructs socio-economic progress. The continuous misuse and overutilization of antibiotics participate mainly in the emergence of microbial resistance. To circumvent such a multidrug-resistance phenomenon, well-defined nanocomposite structures have recently been employed. In the current study, a facile, novel and cost-effective approach was applied to synthesize Ag@Ag2O core–shell nanocomposites (NCs) via chemical method. Several techniques were used to determine the structural, morphological, and optical characteristics of the as-prepared NCs. XRD, Raman, FTIR, XPS and SAED analysis revealed a crystalline hybrid structure of Ag core and Ag2O shell. Besides, SEM and HRTEM micrographs depicted spherical nanoparticles with size range of 19–60 nm. Additionally, zeta potential and fluorescence spectra illustrated aggregated nature of Ag@Ag2O NCs by − 5.34 mV with fluorescence emission peak at 498 nm. Ag@Ag2O NCs exhibited higher antimicrobial, antibiofilm, and algicidal activity in dose-dependent behavior. Interestingly, a remarkable mycocidal potency by 50 μg of Ag@Ag2O NCs against Candida albican; implying promising activity against COVID-19 white fungal post-infections. Through assessing cytotoxicity, Ag@Ag2O NCs exhibited higher safety against Vero cells than bulk silver nitrate by more than 100-fold.Shaimaa ElyamnyMarwa EltarahonyMarwa Abu-SerieMarwa M. NabilAbd El-Hady B. KashyoutNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shaimaa Elyamny Marwa Eltarahony Marwa Abu-Serie Marwa M. Nabil Abd El-Hady B. Kashyout One-pot fabrication of Ag @Ag2O core–shell nanostructures for biosafe antimicrobial and antibiofilm applications
description	Abstract Microbial contamination is one of the major dreadful problems that raises hospitalization, morbidity and mortality rates globally, which subsequently obstructs socio-economic progress. The continuous misuse and overutilization of antibiotics participate mainly in the emergence of microbial resistance. To circumvent such a multidrug-resistance phenomenon, well-defined nanocomposite structures have recently been employed. In the current study, a facile, novel and cost-effective approach was applied to synthesize Ag@Ag2O core–shell nanocomposites (NCs) via chemical method. Several techniques were used to determine the structural, morphological, and optical characteristics of the as-prepared NCs. XRD, Raman, FTIR, XPS and SAED analysis revealed a crystalline hybrid structure of Ag core and Ag2O shell. Besides, SEM and HRTEM micrographs depicted spherical nanoparticles with size range of 19–60 nm. Additionally, zeta potential and fluorescence spectra illustrated aggregated nature of Ag@Ag2O NCs by − 5.34 mV with fluorescence emission peak at 498 nm. Ag@Ag2O NCs exhibited higher antimicrobial, antibiofilm, and algicidal activity in dose-dependent behavior. Interestingly, a remarkable mycocidal potency by 50 μg of Ag@Ag2O NCs against Candida albican; implying promising activity against COVID-19 white fungal post-infections. Through assessing cytotoxicity, Ag@Ag2O NCs exhibited higher safety against Vero cells than bulk silver nitrate by more than 100-fold.
format	article
author	Shaimaa Elyamny Marwa Eltarahony Marwa Abu-Serie Marwa M. Nabil Abd El-Hady B. Kashyout
author_facet	Shaimaa Elyamny Marwa Eltarahony Marwa Abu-Serie Marwa M. Nabil Abd El-Hady B. Kashyout
author_sort	Shaimaa Elyamny
title	One-pot fabrication of Ag @Ag2O core–shell nanostructures for biosafe antimicrobial and antibiofilm applications
title_short	One-pot fabrication of Ag @Ag2O core–shell nanostructures for biosafe antimicrobial and antibiofilm applications
title_full	One-pot fabrication of Ag @Ag2O core–shell nanostructures for biosafe antimicrobial and antibiofilm applications
title_fullStr	One-pot fabrication of Ag @Ag2O core–shell nanostructures for biosafe antimicrobial and antibiofilm applications
title_full_unstemmed	One-pot fabrication of Ag @Ag2O core–shell nanostructures for biosafe antimicrobial and antibiofilm applications
title_sort	one-pot fabrication of ag @ag2o core–shell nanostructures for biosafe antimicrobial and antibiofilm applications
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0d82c886d1ff46e0a8773f40e68cb6cf
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One-pot fabrication of Ag @Ag2O core–shell nanostructures for biosafe antimicrobial and antibiofilm applications

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