P16INK4A expression might be associated with a favorable prognosis for cervical adenocarcinoma via dysregulation of the RB pathway

Abstract Previous studies have largely failed to clarify the relationship between p16INK4A status and cervical adenocarcinoma prognosis. The current study aimed to examine the clinical and pathological significance of p16INK4A expression in several cervical adenocarcinoma subtypes. Eighty-two sample...

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Autores principales:	Masako Ishikawa, Kentaro Nakayama, Kohei Nakamura, Hitomi Yamashita, Tomoka Ishibashi, Toshiko Minamoto, Kiyoka Sawada, Yuki Yoshimura, Kouji Iida, Sultana Razia, Noriyoshi Ishikawa, Satoru Nakayama, Yoshiro Otsuki, Satoru Kyo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0d82f2fd6b9e4b01978f265b8bedcc34
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spelling	oai:doaj.org-article:0d82f2fd6b9e4b01978f265b8bedcc342021-12-02T18:02:23ZP16INK4A expression might be associated with a favorable prognosis for cervical adenocarcinoma via dysregulation of the RB pathway10.1038/s41598-021-97703-82045-2322https://doaj.org/article/0d82f2fd6b9e4b01978f265b8bedcc342021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97703-8https://doaj.org/toc/2045-2322Abstract Previous studies have largely failed to clarify the relationship between p16INK4A status and cervical adenocarcinoma prognosis. The current study aimed to examine the clinical and pathological significance of p16INK4A expression in several cervical adenocarcinoma subtypes. Eighty-two samples collected from patients with cervical adenocarcinoma were formalin fixed and paraffin embedded. Next, p16INK4A levels were analyzed with immunohistochemistry. Additionally, the relationship between p16INK4A expression and clinicopathological factors as well as prognosis was evaluated. The expression of p16INK4A was mostly detected in all usual cervical adenocarcinoma subtypes. In the gastric type, only a few cases were positive for p16INK4A expression. Results of the Kaplan–Meier analysis indicated that the positive p16INK4A expression in tumor cells was significantly associated with favorable progression-free survival and overall survival in patients with cervical adenocarcinoma (p = 0.018 and p = 0.047, respectively, log-rank test). Our findings suggest that the status of p16INK4A expression may influence prognosis. Thus, p16INK4A expression could be used as a biomarker for improving the prognosis of patients with cervical adenocarcinoma.Masako IshikawaKentaro NakayamaKohei NakamuraHitomi YamashitaTomoka IshibashiToshiko MinamotoKiyoka SawadaYuki YoshimuraKouji IidaSultana RaziaNoriyoshi IshikawaSatoru NakayamaYoshiro OtsukiSatoru KyoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masako Ishikawa Kentaro Nakayama Kohei Nakamura Hitomi Yamashita Tomoka Ishibashi Toshiko Minamoto Kiyoka Sawada Yuki Yoshimura Kouji Iida Sultana Razia Noriyoshi Ishikawa Satoru Nakayama Yoshiro Otsuki Satoru Kyo P16INK4A expression might be associated with a favorable prognosis for cervical adenocarcinoma via dysregulation of the RB pathway
description	Abstract Previous studies have largely failed to clarify the relationship between p16INK4A status and cervical adenocarcinoma prognosis. The current study aimed to examine the clinical and pathological significance of p16INK4A expression in several cervical adenocarcinoma subtypes. Eighty-two samples collected from patients with cervical adenocarcinoma were formalin fixed and paraffin embedded. Next, p16INK4A levels were analyzed with immunohistochemistry. Additionally, the relationship between p16INK4A expression and clinicopathological factors as well as prognosis was evaluated. The expression of p16INK4A was mostly detected in all usual cervical adenocarcinoma subtypes. In the gastric type, only a few cases were positive for p16INK4A expression. Results of the Kaplan–Meier analysis indicated that the positive p16INK4A expression in tumor cells was significantly associated with favorable progression-free survival and overall survival in patients with cervical adenocarcinoma (p = 0.018 and p = 0.047, respectively, log-rank test). Our findings suggest that the status of p16INK4A expression may influence prognosis. Thus, p16INK4A expression could be used as a biomarker for improving the prognosis of patients with cervical adenocarcinoma.
format	article
author	Masako Ishikawa Kentaro Nakayama Kohei Nakamura Hitomi Yamashita Tomoka Ishibashi Toshiko Minamoto Kiyoka Sawada Yuki Yoshimura Kouji Iida Sultana Razia Noriyoshi Ishikawa Satoru Nakayama Yoshiro Otsuki Satoru Kyo
author_facet	Masako Ishikawa Kentaro Nakayama Kohei Nakamura Hitomi Yamashita Tomoka Ishibashi Toshiko Minamoto Kiyoka Sawada Yuki Yoshimura Kouji Iida Sultana Razia Noriyoshi Ishikawa Satoru Nakayama Yoshiro Otsuki Satoru Kyo
author_sort	Masako Ishikawa
title	P16INK4A expression might be associated with a favorable prognosis for cervical adenocarcinoma via dysregulation of the RB pathway
title_short	P16INK4A expression might be associated with a favorable prognosis for cervical adenocarcinoma via dysregulation of the RB pathway
title_full	P16INK4A expression might be associated with a favorable prognosis for cervical adenocarcinoma via dysregulation of the RB pathway
title_fullStr	P16INK4A expression might be associated with a favorable prognosis for cervical adenocarcinoma via dysregulation of the RB pathway
title_full_unstemmed	P16INK4A expression might be associated with a favorable prognosis for cervical adenocarcinoma via dysregulation of the RB pathway
title_sort	p16ink4a expression might be associated with a favorable prognosis for cervical adenocarcinoma via dysregulation of the rb pathway
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0d82f2fd6b9e4b01978f265b8bedcc34
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P16INK4A expression might be associated with a favorable prognosis for cervical adenocarcinoma via dysregulation of the RB pathway

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