FoxG1 regulates the formation of cortical GABAergic circuit during an early postnatal critical period resulting in autism spectrum disorder-like phenotypes

Cortical excitatory/inhibitory (E/I) imbalance is a feature of autism spectrum disorder (ASD). Here, the authors show that FoxG1 regulates the formation of cortical GABAergic circuits affecting social behaviour during a specific postnatal time window in mouse models of ASD.

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Autores principales:	Goichi Miyoshi, Yoshifumi Ueta, Akiyo Natsubori, Kou Hiraga, Hironobu Osaki, Yuki Yagasaki, Yusuke Kishi, Yuchio Yanagawa, Gord Fishell, Robert P. Machold, Mariko Miyata
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0d87268f0ff047db8199f133dea6efb5
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spelling	oai:doaj.org-article:0d87268f0ff047db8199f133dea6efb52021-12-02T17:23:59ZFoxG1 regulates the formation of cortical GABAergic circuit during an early postnatal critical period resulting in autism spectrum disorder-like phenotypes10.1038/s41467-021-23987-z2041-1723https://doaj.org/article/0d87268f0ff047db8199f133dea6efb52021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23987-zhttps://doaj.org/toc/2041-1723Cortical excitatory/inhibitory (E/I) imbalance is a feature of autism spectrum disorder (ASD). Here, the authors show that FoxG1 regulates the formation of cortical GABAergic circuits affecting social behaviour during a specific postnatal time window in mouse models of ASD.Goichi MiyoshiYoshifumi UetaAkiyo NatsuboriKou HiragaHironobu OsakiYuki YagasakiYusuke KishiYuchio YanagawaGord FishellRobert P. MacholdMariko MiyataNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Goichi Miyoshi Yoshifumi Ueta Akiyo Natsubori Kou Hiraga Hironobu Osaki Yuki Yagasaki Yusuke Kishi Yuchio Yanagawa Gord Fishell Robert P. Machold Mariko Miyata FoxG1 regulates the formation of cortical GABAergic circuit during an early postnatal critical period resulting in autism spectrum disorder-like phenotypes
description	Cortical excitatory/inhibitory (E/I) imbalance is a feature of autism spectrum disorder (ASD). Here, the authors show that FoxG1 regulates the formation of cortical GABAergic circuits affecting social behaviour during a specific postnatal time window in mouse models of ASD.
format	article
author	Goichi Miyoshi Yoshifumi Ueta Akiyo Natsubori Kou Hiraga Hironobu Osaki Yuki Yagasaki Yusuke Kishi Yuchio Yanagawa Gord Fishell Robert P. Machold Mariko Miyata
author_facet	Goichi Miyoshi Yoshifumi Ueta Akiyo Natsubori Kou Hiraga Hironobu Osaki Yuki Yagasaki Yusuke Kishi Yuchio Yanagawa Gord Fishell Robert P. Machold Mariko Miyata
author_sort	Goichi Miyoshi
title	FoxG1 regulates the formation of cortical GABAergic circuit during an early postnatal critical period resulting in autism spectrum disorder-like phenotypes
title_short	FoxG1 regulates the formation of cortical GABAergic circuit during an early postnatal critical period resulting in autism spectrum disorder-like phenotypes
title_full	FoxG1 regulates the formation of cortical GABAergic circuit during an early postnatal critical period resulting in autism spectrum disorder-like phenotypes
title_fullStr	FoxG1 regulates the formation of cortical GABAergic circuit during an early postnatal critical period resulting in autism spectrum disorder-like phenotypes
title_full_unstemmed	FoxG1 regulates the formation of cortical GABAergic circuit during an early postnatal critical period resulting in autism spectrum disorder-like phenotypes
title_sort	foxg1 regulates the formation of cortical gabaergic circuit during an early postnatal critical period resulting in autism spectrum disorder-like phenotypes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0d87268f0ff047db8199f133dea6efb5
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FoxG1 regulates the formation of cortical GABAergic circuit during an early postnatal critical period resulting in autism spectrum disorder-like phenotypes

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