SSRP1-mediated histone H1 eviction promotes replication origin assembly and accelerated development

During embryonic development, it is vital to maintain rapid genome duplication. Here, the authors shed light on the mechanism by revealing that SSRP1 stimulates replication origin assembly on somatic nuclei in Xenopus laevis egg extract by promoting histone H1 eviction from somatic chromatin.

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Autores principales:	Lucia Falbo, Erica Raspelli, Francesco Romeo, Simona Fiorani, Federica Pezzimenti, Francesca Casagrande, Ilaria Costa, Dario Parazzoli, Vincenzo Costanzo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0d8b5f46cc10411b9cf6cb02f0892298
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spelling	oai:doaj.org-article:0d8b5f46cc10411b9cf6cb02f08922982021-12-02T14:41:01ZSSRP1-mediated histone H1 eviction promotes replication origin assembly and accelerated development10.1038/s41467-020-15180-52041-1723https://doaj.org/article/0d8b5f46cc10411b9cf6cb02f08922982020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15180-5https://doaj.org/toc/2041-1723During embryonic development, it is vital to maintain rapid genome duplication. Here, the authors shed light on the mechanism by revealing that SSRP1 stimulates replication origin assembly on somatic nuclei in Xenopus laevis egg extract by promoting histone H1 eviction from somatic chromatin.Lucia FalboErica RaspelliFrancesco RomeoSimona FioraniFederica PezzimentiFrancesca CasagrandeIlaria CostaDario ParazzoliVincenzo CostanzoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lucia Falbo Erica Raspelli Francesco Romeo Simona Fiorani Federica Pezzimenti Francesca Casagrande Ilaria Costa Dario Parazzoli Vincenzo Costanzo SSRP1-mediated histone H1 eviction promotes replication origin assembly and accelerated development
description	During embryonic development, it is vital to maintain rapid genome duplication. Here, the authors shed light on the mechanism by revealing that SSRP1 stimulates replication origin assembly on somatic nuclei in Xenopus laevis egg extract by promoting histone H1 eviction from somatic chromatin.
format	article
author	Lucia Falbo Erica Raspelli Francesco Romeo Simona Fiorani Federica Pezzimenti Francesca Casagrande Ilaria Costa Dario Parazzoli Vincenzo Costanzo
author_facet	Lucia Falbo Erica Raspelli Francesco Romeo Simona Fiorani Federica Pezzimenti Francesca Casagrande Ilaria Costa Dario Parazzoli Vincenzo Costanzo
author_sort	Lucia Falbo
title	SSRP1-mediated histone H1 eviction promotes replication origin assembly and accelerated development
title_short	SSRP1-mediated histone H1 eviction promotes replication origin assembly and accelerated development
title_full	SSRP1-mediated histone H1 eviction promotes replication origin assembly and accelerated development
title_fullStr	SSRP1-mediated histone H1 eviction promotes replication origin assembly and accelerated development
title_full_unstemmed	SSRP1-mediated histone H1 eviction promotes replication origin assembly and accelerated development
title_sort	ssrp1-mediated histone h1 eviction promotes replication origin assembly and accelerated development
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0d8b5f46cc10411b9cf6cb02f0892298
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SSRP1-mediated histone H1 eviction promotes replication origin assembly and accelerated development

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