Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease

Heart development requires compaction of the ventricular wall into a dense myocardium at mid-gestation. Here, Rhee and colleagues show that the chromatin remodeller Ino80 is critical for the formation of the coronary vasculature, and show that coronary vessels are needed for successful cardiac compa...

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Autores principales:	Siyeon Rhee, Jae I. Chung, Devin A. King, Gaetano D’amato, David T. Paik, Anna Duan, Andrew Chang, Danielle Nagelberg, Bikram Sharma, Youngtae Jeong, Maximilian Diehn, Joseph C. Wu, Ashby J. Morrison, Kristy Red-Horse
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0d8c87a059fa43f486965f124732ed10
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spelling	oai:doaj.org-article:0d8c87a059fa43f486965f124732ed102021-12-02T17:32:17ZEndothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease10.1038/s41467-017-02796-32041-1723https://doaj.org/article/0d8c87a059fa43f486965f124732ed102018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02796-3https://doaj.org/toc/2041-1723Heart development requires compaction of the ventricular wall into a dense myocardium at mid-gestation. Here, Rhee and colleagues show that the chromatin remodeller Ino80 is critical for the formation of the coronary vasculature, and show that coronary vessels are needed for successful cardiac compaction during embryonic development.Siyeon RheeJae I. ChungDevin A. KingGaetano D’amatoDavid T. PaikAnna DuanAndrew ChangDanielle NagelbergBikram SharmaYoungtae JeongMaximilian DiehnJoseph C. WuAshby J. MorrisonKristy Red-HorseNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Siyeon Rhee Jae I. Chung Devin A. King Gaetano D’amato David T. Paik Anna Duan Andrew Chang Danielle Nagelberg Bikram Sharma Youngtae Jeong Maximilian Diehn Joseph C. Wu Ashby J. Morrison Kristy Red-Horse Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease
description	Heart development requires compaction of the ventricular wall into a dense myocardium at mid-gestation. Here, Rhee and colleagues show that the chromatin remodeller Ino80 is critical for the formation of the coronary vasculature, and show that coronary vessels are needed for successful cardiac compaction during embryonic development.
format	article
author	Siyeon Rhee Jae I. Chung Devin A. King Gaetano D’amato David T. Paik Anna Duan Andrew Chang Danielle Nagelberg Bikram Sharma Youngtae Jeong Maximilian Diehn Joseph C. Wu Ashby J. Morrison Kristy Red-Horse
author_facet	Siyeon Rhee Jae I. Chung Devin A. King Gaetano D’amato David T. Paik Anna Duan Andrew Chang Danielle Nagelberg Bikram Sharma Youngtae Jeong Maximilian Diehn Joseph C. Wu Ashby J. Morrison Kristy Red-Horse
author_sort	Siyeon Rhee
title	Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease
title_short	Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease
title_full	Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease
title_fullStr	Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease
title_full_unstemmed	Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease
title_sort	endothelial deletion of ino80 disrupts coronary angiogenesis and causes congenital heart disease
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0d8c87a059fa43f486965f124732ed10
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Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease

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