Prognosis of liver transplantation: Does postoperative ileus matter?

Abstract Background Nowadays, liver transplantation has become a main therapy for end-stage liver disease. However, studies show that there are high mortality and severe complications after liver transplantation. Although gastrointestinal dysfunction is a common and major complication after liver tr...

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Autores principales:	Ruiping Bai, Rui An, Kunyu Han, Mengwen Xue, Simei Zhang, Xin Shen, Shaohua Zheng
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Liver transplantation Postoperative ileus MELD score Child–Pugh score Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/0d8f5de9bcf4434497a9305c297bb5a4
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spelling	oai:doaj.org-article:0d8f5de9bcf4434497a9305c297bb5a42021-11-28T12:14:53ZPrognosis of liver transplantation: Does postoperative ileus matter?10.1186/s12876-021-02026-71471-230Xhttps://doaj.org/article/0d8f5de9bcf4434497a9305c297bb5a42021-11-01T00:00:00Zhttps://doi.org/10.1186/s12876-021-02026-7https://doaj.org/toc/1471-230XAbstract Background Nowadays, liver transplantation has become a main therapy for end-stage liver disease. However, studies show that there are high mortality and severe complications after liver transplantation. Although gastrointestinal dysfunction is a common and major complication after liver transplantation, there was rarely relative research. This study aims to elucidate the factors about ileus after liver transplantation and patients’ survival. Methods We collected and analyzed the data (n = 318, 2016–2019) from the First Affiliated Hospital of Xi’an Jiaotong University. After excluding cases, a total of 293 patients were included for this study. The subjects were divided into a non-ileus group and an ileus group. We reviewed 38 variables (including preoperative, operative and postoperative relative factors). Additionally, other complications after liver transplantation and survival data were compared between two groups. Results Of the 293 patients, 23.2% (n = 68) experienced postoperative ileus. Ileus patients were not different with non-ileus patients in preoperative, operative and postoperative factors. HBV-positive patients with ileus had a lower MELD score (P = 0.025), and lower postoperative total bilirubin was correlated with ileus (P = 0.049). Besides, Child–Pugh score of HCC patients with ileus was low (P = 0.029). The complications after liver transplantation were not different between two groups. Compared with the patients without ileus, the patients with ileus had a higher mortality rate. Conclusion According to our research, ileus-patients had a lower 1-year survival rates. The preoperative MELD score and postoperative total bilirubin of HBV-positive patients with ileus were lower, and Child–Pugh score of HCC patients with ileus was also lower.Ruiping BaiRui AnKunyu HanMengwen XueSimei ZhangXin ShenShaohua ZhengBMCarticleLiver transplantationPostoperative ileusMELD scoreChild–Pugh scoreDiseases of the digestive system. GastroenterologyRC799-869ENBMC Gastroenterology, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Liver transplantation Postoperative ileus MELD score Child–Pugh score Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Liver transplantation Postoperative ileus MELD score Child–Pugh score Diseases of the digestive system. Gastroenterology RC799-869 Ruiping Bai Rui An Kunyu Han Mengwen Xue Simei Zhang Xin Shen Shaohua Zheng Prognosis of liver transplantation: Does postoperative ileus matter?
description	Abstract Background Nowadays, liver transplantation has become a main therapy for end-stage liver disease. However, studies show that there are high mortality and severe complications after liver transplantation. Although gastrointestinal dysfunction is a common and major complication after liver transplantation, there was rarely relative research. This study aims to elucidate the factors about ileus after liver transplantation and patients’ survival. Methods We collected and analyzed the data (n = 318, 2016–2019) from the First Affiliated Hospital of Xi’an Jiaotong University. After excluding cases, a total of 293 patients were included for this study. The subjects were divided into a non-ileus group and an ileus group. We reviewed 38 variables (including preoperative, operative and postoperative relative factors). Additionally, other complications after liver transplantation and survival data were compared between two groups. Results Of the 293 patients, 23.2% (n = 68) experienced postoperative ileus. Ileus patients were not different with non-ileus patients in preoperative, operative and postoperative factors. HBV-positive patients with ileus had a lower MELD score (P = 0.025), and lower postoperative total bilirubin was correlated with ileus (P = 0.049). Besides, Child–Pugh score of HCC patients with ileus was low (P = 0.029). The complications after liver transplantation were not different between two groups. Compared with the patients without ileus, the patients with ileus had a higher mortality rate. Conclusion According to our research, ileus-patients had a lower 1-year survival rates. The preoperative MELD score and postoperative total bilirubin of HBV-positive patients with ileus were lower, and Child–Pugh score of HCC patients with ileus was also lower.
format	article
author	Ruiping Bai Rui An Kunyu Han Mengwen Xue Simei Zhang Xin Shen Shaohua Zheng
author_facet	Ruiping Bai Rui An Kunyu Han Mengwen Xue Simei Zhang Xin Shen Shaohua Zheng
author_sort	Ruiping Bai
title	Prognosis of liver transplantation: Does postoperative ileus matter?
title_short	Prognosis of liver transplantation: Does postoperative ileus matter?
title_full	Prognosis of liver transplantation: Does postoperative ileus matter?
title_fullStr	Prognosis of liver transplantation: Does postoperative ileus matter?
title_full_unstemmed	Prognosis of liver transplantation: Does postoperative ileus matter?
title_sort	prognosis of liver transplantation: does postoperative ileus matter?
publisher	BMC
publishDate	2021
url	https://doaj.org/article/0d8f5de9bcf4434497a9305c297bb5a4
work_keys_str_mv	AT ruipingbai prognosisoflivertransplantationdoespostoperativeileusmatter AT ruian prognosisoflivertransplantationdoespostoperativeileusmatter AT kunyuhan prognosisoflivertransplantationdoespostoperativeileusmatter AT mengwenxue prognosisoflivertransplantationdoespostoperativeileusmatter AT simeizhang prognosisoflivertransplantationdoespostoperativeileusmatter AT xinshen prognosisoflivertransplantationdoespostoperativeileusmatter AT shaohuazheng prognosisoflivertransplantationdoespostoperativeileusmatter
_version_	1718408058848149504

Prognosis of liver transplantation: Does postoperative ileus matter?

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