Relaxation along a fictitious field (RAFF) and Z-spectroscopy using alternating-phase irradiation (ZAPI) in permanent focal cerebral ischemia in rat.

Cerebral ischemia alters the molecular dynamics and content of water in brain tissue, which is reflected in NMR relaxation, diffusion and magnetization transfer (MT) parameters. In this study, the behavior of two new MRI contrasts, Relaxation Along a Fictitious Field (RAFF) and Z-spectroscopy using...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kimmo T Jokivarsi, Timo Liimatainen, Risto A Kauppinen, Olli H J Gröhn, Johanna Närväinen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0d90b49130f64d9384267615872b0d7d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0d90b49130f64d9384267615872b0d7d
record_format	dspace
spelling	oai:doaj.org-article:0d90b49130f64d9384267615872b0d7d2021-11-18T07:37:21ZRelaxation along a fictitious field (RAFF) and Z-spectroscopy using alternating-phase irradiation (ZAPI) in permanent focal cerebral ischemia in rat.1932-620310.1371/journal.pone.0069157https://doaj.org/article/0d90b49130f64d9384267615872b0d7d2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23874898/?tool=EBIhttps://doaj.org/toc/1932-6203Cerebral ischemia alters the molecular dynamics and content of water in brain tissue, which is reflected in NMR relaxation, diffusion and magnetization transfer (MT) parameters. In this study, the behavior of two new MRI contrasts, Relaxation Along a Fictitious Field (RAFF) and Z-spectroscopy using Alternating-Phase Irradiation (ZAPI), were quantified together with conventional relaxation parameters (T1, T2 and T1ρ) and MT ratios in acute cerebral ischemia in rat. The right middle cerebral artery was permanently occluded and quantitative MRI data was acquired sequentially for the above parameters for up to 6 hours. The following conclusions were drawn: 1) Time-dependent changes in RAFF and T1ρ relaxation are not coupled to those in MT. 2) RAFF relaxation evolves more like transverse, rather than longitudinal relaxation. 3) MT measured with ZAPI is less sensitive to ischemia than conventional MT. 4) ZAPI data suggest alterations in the T2 distribution of macromolecules in acute cerebral ischemia. It was shown that both RAFF and ZAPI provide complementary MRI information from acute ischemic brain tissue. The presented multiparametric MRI data may aid in the assessment of brain tissue status early in ischemic stroke.Kimmo T JokivarsiTimo LiimatainenRisto A KauppinenOlli H J GröhnJohanna NärväinenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e69157 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kimmo T Jokivarsi Timo Liimatainen Risto A Kauppinen Olli H J Gröhn Johanna Närväinen Relaxation along a fictitious field (RAFF) and Z-spectroscopy using alternating-phase irradiation (ZAPI) in permanent focal cerebral ischemia in rat.
description	Cerebral ischemia alters the molecular dynamics and content of water in brain tissue, which is reflected in NMR relaxation, diffusion and magnetization transfer (MT) parameters. In this study, the behavior of two new MRI contrasts, Relaxation Along a Fictitious Field (RAFF) and Z-spectroscopy using Alternating-Phase Irradiation (ZAPI), were quantified together with conventional relaxation parameters (T1, T2 and T1ρ) and MT ratios in acute cerebral ischemia in rat. The right middle cerebral artery was permanently occluded and quantitative MRI data was acquired sequentially for the above parameters for up to 6 hours. The following conclusions were drawn: 1) Time-dependent changes in RAFF and T1ρ relaxation are not coupled to those in MT. 2) RAFF relaxation evolves more like transverse, rather than longitudinal relaxation. 3) MT measured with ZAPI is less sensitive to ischemia than conventional MT. 4) ZAPI data suggest alterations in the T2 distribution of macromolecules in acute cerebral ischemia. It was shown that both RAFF and ZAPI provide complementary MRI information from acute ischemic brain tissue. The presented multiparametric MRI data may aid in the assessment of brain tissue status early in ischemic stroke.
format	article
author	Kimmo T Jokivarsi Timo Liimatainen Risto A Kauppinen Olli H J Gröhn Johanna Närväinen
author_facet	Kimmo T Jokivarsi Timo Liimatainen Risto A Kauppinen Olli H J Gröhn Johanna Närväinen
author_sort	Kimmo T Jokivarsi
title	Relaxation along a fictitious field (RAFF) and Z-spectroscopy using alternating-phase irradiation (ZAPI) in permanent focal cerebral ischemia in rat.
title_short	Relaxation along a fictitious field (RAFF) and Z-spectroscopy using alternating-phase irradiation (ZAPI) in permanent focal cerebral ischemia in rat.
title_full	Relaxation along a fictitious field (RAFF) and Z-spectroscopy using alternating-phase irradiation (ZAPI) in permanent focal cerebral ischemia in rat.
title_fullStr	Relaxation along a fictitious field (RAFF) and Z-spectroscopy using alternating-phase irradiation (ZAPI) in permanent focal cerebral ischemia in rat.
title_full_unstemmed	Relaxation along a fictitious field (RAFF) and Z-spectroscopy using alternating-phase irradiation (ZAPI) in permanent focal cerebral ischemia in rat.
title_sort	relaxation along a fictitious field (raff) and z-spectroscopy using alternating-phase irradiation (zapi) in permanent focal cerebral ischemia in rat.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/0d90b49130f64d9384267615872b0d7d
work_keys_str_mv	AT kimmotjokivarsi relaxationalongafictitiousfieldraffandzspectroscopyusingalternatingphaseirradiationzapiinpermanentfocalcerebralischemiainrat AT timoliimatainen relaxationalongafictitiousfieldraffandzspectroscopyusingalternatingphaseirradiationzapiinpermanentfocalcerebralischemiainrat AT ristoakauppinen relaxationalongafictitiousfieldraffandzspectroscopyusingalternatingphaseirradiationzapiinpermanentfocalcerebralischemiainrat AT ollihjgrohn relaxationalongafictitiousfieldraffandzspectroscopyusingalternatingphaseirradiationzapiinpermanentfocalcerebralischemiainrat AT johannanarvainen relaxationalongafictitiousfieldraffandzspectroscopyusingalternatingphaseirradiationzapiinpermanentfocalcerebralischemiainrat
_version_	1718423141446844416

Relaxation along a fictitious field (RAFF) and Z-spectroscopy using alternating-phase irradiation (ZAPI) in permanent focal cerebral ischemia in rat.

Ejemplares similares