HIV/SIV infection primes monocytes and dendritic cells for apoptosis.

Subversion or exacerbation of antigen-presenting cells (APC) death modulates host/pathogen equilibrium. We demonstrated during in vitro differentiation of monocyte-derived macrophages and monocyte-derived dendritic cells (DCs) that HIV sensitizes the cells to undergo apoptosis in response to TRAIL a...

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Autores principales:	Mireille Laforge, Laure Campillo-Gimenez, Valérie Monceaux, Marie-Christine Cumont, Bruno Hurtrel, Jacques Corbeil, John Zaunders, Carole Elbim, Jérôme Estaquier
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0d9479ce59ce42359ce7cea759fab099
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spelling	oai:doaj.org-article:0d9479ce59ce42359ce7cea759fab0992021-11-18T06:03:17ZHIV/SIV infection primes monocytes and dendritic cells for apoptosis.1553-73661553-737410.1371/journal.ppat.1002087https://doaj.org/article/0d9479ce59ce42359ce7cea759fab0992011-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21731488/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Subversion or exacerbation of antigen-presenting cells (APC) death modulates host/pathogen equilibrium. We demonstrated during in vitro differentiation of monocyte-derived macrophages and monocyte-derived dendritic cells (DCs) that HIV sensitizes the cells to undergo apoptosis in response to TRAIL and FasL, respectively. In addition, we found that HIV-1 increased the levels of pro-apoptotic Bax and Bak molecules and decreased the levels of anti-apoptotic Mcl-1 and FLIP proteins. To assess the relevance of these observations in the context of an experimental model of HIV infection, we investigated the death of APC during pathogenic SIV-infection in rhesus macaques (RMs). We demonstrated increased apoptosis, during the acute phase, of both peripheral blood DCs and monocytes (CD14(+)) from SIV(+)RMs, associated with a dysregulation in the balance of pro- and anti-apoptotic molecules. Caspase-inhibitor and death receptors antagonists prevented apoptosis of APCs from SIV(+)RMs. Furthermore, increased levels of FasL in the sera of pathogenic SIV(+)RMs were detected, compared to non-pathogenic SIV infection of African green monkey. We suggest that inappropriate apoptosis of antigen-presenting cells may contribute to dysregulation of cellular immunity early in the process of HIV/SIV infection.Mireille LaforgeLaure Campillo-GimenezValérie MonceauxMarie-Christine CumontBruno HurtrelJacques CorbeilJohn ZaundersCarole ElbimJérôme EstaquierPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 7, Iss 6, p e1002087 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Mireille Laforge Laure Campillo-Gimenez Valérie Monceaux Marie-Christine Cumont Bruno Hurtrel Jacques Corbeil John Zaunders Carole Elbim Jérôme Estaquier HIV/SIV infection primes monocytes and dendritic cells for apoptosis.
description	Subversion or exacerbation of antigen-presenting cells (APC) death modulates host/pathogen equilibrium. We demonstrated during in vitro differentiation of monocyte-derived macrophages and monocyte-derived dendritic cells (DCs) that HIV sensitizes the cells to undergo apoptosis in response to TRAIL and FasL, respectively. In addition, we found that HIV-1 increased the levels of pro-apoptotic Bax and Bak molecules and decreased the levels of anti-apoptotic Mcl-1 and FLIP proteins. To assess the relevance of these observations in the context of an experimental model of HIV infection, we investigated the death of APC during pathogenic SIV-infection in rhesus macaques (RMs). We demonstrated increased apoptosis, during the acute phase, of both peripheral blood DCs and monocytes (CD14(+)) from SIV(+)RMs, associated with a dysregulation in the balance of pro- and anti-apoptotic molecules. Caspase-inhibitor and death receptors antagonists prevented apoptosis of APCs from SIV(+)RMs. Furthermore, increased levels of FasL in the sera of pathogenic SIV(+)RMs were detected, compared to non-pathogenic SIV infection of African green monkey. We suggest that inappropriate apoptosis of antigen-presenting cells may contribute to dysregulation of cellular immunity early in the process of HIV/SIV infection.
format	article
author	Mireille Laforge Laure Campillo-Gimenez Valérie Monceaux Marie-Christine Cumont Bruno Hurtrel Jacques Corbeil John Zaunders Carole Elbim Jérôme Estaquier
author_facet	Mireille Laforge Laure Campillo-Gimenez Valérie Monceaux Marie-Christine Cumont Bruno Hurtrel Jacques Corbeil John Zaunders Carole Elbim Jérôme Estaquier
author_sort	Mireille Laforge
title	HIV/SIV infection primes monocytes and dendritic cells for apoptosis.
title_short	HIV/SIV infection primes monocytes and dendritic cells for apoptosis.
title_full	HIV/SIV infection primes monocytes and dendritic cells for apoptosis.
title_fullStr	HIV/SIV infection primes monocytes and dendritic cells for apoptosis.
title_full_unstemmed	HIV/SIV infection primes monocytes and dendritic cells for apoptosis.
title_sort	hiv/siv infection primes monocytes and dendritic cells for apoptosis.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/0d9479ce59ce42359ce7cea759fab099
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HIV/SIV infection primes monocytes and dendritic cells for apoptosis.

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