Endocervical and vaginal microbiota in South African adolescents with asymptomatic Chlamydia trachomatis infection

Abstract Adolescent girls and young women represent a key risk group for sexually transmitted infections (STIs). The vaginal microbiota is thought to play an important role in susceptibility to STIs such as Chlamydia trachomatis. We compared the microbiota of the lateral vaginal wall and endocervix,...

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Autores principales:	Christina Balle, Katie Lennard, Smritee Dabee, Shaun L. Barnabas, Shameem Z. Jaumdally, Melanie A. Gasper, Venessa Maseko, Zizipho Z. A. Mbulawa, Anna-Lise Williamson, Linda-Gail Bekker, David A. Lewis, Jo-Ann S. Passmore, Heather B. Jaspan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0d9492386e6d40e6bc097632cf7cb91e
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spelling	oai:doaj.org-article:0d9492386e6d40e6bc097632cf7cb91e2021-12-02T15:07:47ZEndocervical and vaginal microbiota in South African adolescents with asymptomatic Chlamydia trachomatis infection10.1038/s41598-018-29320-x2045-2322https://doaj.org/article/0d9492386e6d40e6bc097632cf7cb91e2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-29320-xhttps://doaj.org/toc/2045-2322Abstract Adolescent girls and young women represent a key risk group for sexually transmitted infections (STIs). The vaginal microbiota is thought to play an important role in susceptibility to STIs such as Chlamydia trachomatis. We compared the microbiota of the lateral vaginal wall and endocervix, and assessed associations with C. trachomatis infection in South African adolescents. The endocervical and vaginal lateral wall microbiota were characterized by amplifying and sequencing the V4 region of the 16S rRNA gene and C. trachomatis diagnosed using molecular methods. Of the 72 girls included, 30 had asymptomatic C. trachomatis infections. Three major vaginal community types were identified; one Lactobacillus crispatus, one L. iners and one diverse, Gardnerella vaginalis dominant. The microbiota of the endocervix was significantly different from that of the lateral wall in terms of diversity. There were many differentially abundant taxa between the endocervix and lateral vaginal wall, including Achromobacter spanius and Enterococcus faecium. Women with C. trachomatis had higher relative abundance of G. vaginalis and other anaerobes. In this African adolescent cohort, significant differences between the lateral vaginal wall and endocervical microbiota diversity and composition were evident, although neither were strongly associated with C. trachomatis infection.Christina BalleKatie LennardSmritee DabeeShaun L. BarnabasShameem Z. JaumdallyMelanie A. GasperVenessa MasekoZizipho Z. A. MbulawaAnna-Lise WilliamsonLinda-Gail BekkerDavid A. LewisJo-Ann S. PassmoreHeather B. JaspanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christina Balle Katie Lennard Smritee Dabee Shaun L. Barnabas Shameem Z. Jaumdally Melanie A. Gasper Venessa Maseko Zizipho Z. A. Mbulawa Anna-Lise Williamson Linda-Gail Bekker David A. Lewis Jo-Ann S. Passmore Heather B. Jaspan Endocervical and vaginal microbiota in South African adolescents with asymptomatic Chlamydia trachomatis infection
description	Abstract Adolescent girls and young women represent a key risk group for sexually transmitted infections (STIs). The vaginal microbiota is thought to play an important role in susceptibility to STIs such as Chlamydia trachomatis. We compared the microbiota of the lateral vaginal wall and endocervix, and assessed associations with C. trachomatis infection in South African adolescents. The endocervical and vaginal lateral wall microbiota were characterized by amplifying and sequencing the V4 region of the 16S rRNA gene and C. trachomatis diagnosed using molecular methods. Of the 72 girls included, 30 had asymptomatic C. trachomatis infections. Three major vaginal community types were identified; one Lactobacillus crispatus, one L. iners and one diverse, Gardnerella vaginalis dominant. The microbiota of the endocervix was significantly different from that of the lateral wall in terms of diversity. There were many differentially abundant taxa between the endocervix and lateral vaginal wall, including Achromobacter spanius and Enterococcus faecium. Women with C. trachomatis had higher relative abundance of G. vaginalis and other anaerobes. In this African adolescent cohort, significant differences between the lateral vaginal wall and endocervical microbiota diversity and composition were evident, although neither were strongly associated with C. trachomatis infection.
format	article
author	Christina Balle Katie Lennard Smritee Dabee Shaun L. Barnabas Shameem Z. Jaumdally Melanie A. Gasper Venessa Maseko Zizipho Z. A. Mbulawa Anna-Lise Williamson Linda-Gail Bekker David A. Lewis Jo-Ann S. Passmore Heather B. Jaspan
author_facet	Christina Balle Katie Lennard Smritee Dabee Shaun L. Barnabas Shameem Z. Jaumdally Melanie A. Gasper Venessa Maseko Zizipho Z. A. Mbulawa Anna-Lise Williamson Linda-Gail Bekker David A. Lewis Jo-Ann S. Passmore Heather B. Jaspan
author_sort	Christina Balle
title	Endocervical and vaginal microbiota in South African adolescents with asymptomatic Chlamydia trachomatis infection
title_short	Endocervical and vaginal microbiota in South African adolescents with asymptomatic Chlamydia trachomatis infection
title_full	Endocervical and vaginal microbiota in South African adolescents with asymptomatic Chlamydia trachomatis infection
title_fullStr	Endocervical and vaginal microbiota in South African adolescents with asymptomatic Chlamydia trachomatis infection
title_full_unstemmed	Endocervical and vaginal microbiota in South African adolescents with asymptomatic Chlamydia trachomatis infection
title_sort	endocervical and vaginal microbiota in south african adolescents with asymptomatic chlamydia trachomatis infection
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0d9492386e6d40e6bc097632cf7cb91e
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Endocervical and vaginal microbiota in South African adolescents with asymptomatic Chlamydia trachomatis infection

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