TUMOR NECROSIS FACTOR-α MEMBRANE-BOUND AND SOLUBLE RECEPTORS IN NORM AND IN RHEUMATOID ARTHRITIS

TNFα — a multifunctional pleiotropic cytokine, considered to have a special significance in the immunopathogenesis of rheumatoid arthritis. Herewith the effectiveness of immunomodulatory cytokine and its role in the development of pathological states of the organism may depend largely on the content...

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Autores principales:	A. A. Alshevskaya, F. F. Vasiliev, J. A. Lopatnikova, S. V. Sennikov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	tnfα membrane-bound receptors rheumatoid arthritis Science Q
Acceso en línea:	https://doaj.org/article/0d9495723b1d4de8a34f6e6fa6e0a7e8
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spelling	oai:doaj.org-article:0d9495723b1d4de8a34f6e6fa6e0a7e82021-11-23T06:14:19ZTUMOR NECROSIS FACTOR-α MEMBRANE-BOUND AND SOLUBLE RECEPTORS IN NORM AND IN RHEUMATOID ARTHRITIS2541-94202587-9596https://doaj.org/article/0d9495723b1d4de8a34f6e6fa6e0a7e82012-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/878https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596TNFα — a multifunctional pleiotropic cytokine, considered to have a special significance in the immunopathogenesis of rheumatoid arthritis. Herewith the effectiveness of immunomodulatory cytokine and its role in the development of pathological states of the organism may depend largely on the content of soluble receptors and expression of membrane-bound receptors. The study shows several significant differences not only in the percentage of cells with. TNFα receptors, but also in the absolute number of receptors expressed on cells from different subsets of immunocompetent cells in health and in rheumatoid arthritis, establishes correlation relationships of these parameters with serum contents of the cytokine and its soluble receptors. The mechanisms and the role of changes in the expression of TNFα receptors in different subsets of leukocytes in immunopathological state and in compare with healthy donors are discussed.A. A. AlshevskayaF. F. VasilievJ. A. LopatnikovaS. V. SennikovScientific Сentre for Family Health and Human Reproduction Problemsarticletnfαtnfαmembrane-bound receptorsrheumatoid arthritisScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 23-28 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	tnfα tnfα membrane-bound receptors rheumatoid arthritis Science Q
spellingShingle	tnfα tnfα membrane-bound receptors rheumatoid arthritis Science Q A. A. Alshevskaya F. F. Vasiliev J. A. Lopatnikova S. V. Sennikov TUMOR NECROSIS FACTOR-α MEMBRANE-BOUND AND SOLUBLE RECEPTORS IN NORM AND IN RHEUMATOID ARTHRITIS
description	TNFα — a multifunctional pleiotropic cytokine, considered to have a special significance in the immunopathogenesis of rheumatoid arthritis. Herewith the effectiveness of immunomodulatory cytokine and its role in the development of pathological states of the organism may depend largely on the content of soluble receptors and expression of membrane-bound receptors. The study shows several significant differences not only in the percentage of cells with. TNFα receptors, but also in the absolute number of receptors expressed on cells from different subsets of immunocompetent cells in health and in rheumatoid arthritis, establishes correlation relationships of these parameters with serum contents of the cytokine and its soluble receptors. The mechanisms and the role of changes in the expression of TNFα receptors in different subsets of leukocytes in immunopathological state and in compare with healthy donors are discussed.
format	article
author	A. A. Alshevskaya F. F. Vasiliev J. A. Lopatnikova S. V. Sennikov
author_facet	A. A. Alshevskaya F. F. Vasiliev J. A. Lopatnikova S. V. Sennikov
author_sort	A. A. Alshevskaya
title	TUMOR NECROSIS FACTOR-α MEMBRANE-BOUND AND SOLUBLE RECEPTORS IN NORM AND IN RHEUMATOID ARTHRITIS
title_short	TUMOR NECROSIS FACTOR-α MEMBRANE-BOUND AND SOLUBLE RECEPTORS IN NORM AND IN RHEUMATOID ARTHRITIS
title_full	TUMOR NECROSIS FACTOR-α MEMBRANE-BOUND AND SOLUBLE RECEPTORS IN NORM AND IN RHEUMATOID ARTHRITIS
title_fullStr	TUMOR NECROSIS FACTOR-α MEMBRANE-BOUND AND SOLUBLE RECEPTORS IN NORM AND IN RHEUMATOID ARTHRITIS
title_full_unstemmed	TUMOR NECROSIS FACTOR-α MEMBRANE-BOUND AND SOLUBLE RECEPTORS IN NORM AND IN RHEUMATOID ARTHRITIS
title_sort	tumor necrosis factor-α membrane-bound and soluble receptors in norm and in rheumatoid arthritis
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/0d9495723b1d4de8a34f6e6fa6e0a7e8
work_keys_str_mv	AT aaalshevskaya tumornecrosisfactoramembraneboundandsolublereceptorsinnormandinrheumatoidarthritis AT ffvasiliev tumornecrosisfactoramembraneboundandsolublereceptorsinnormandinrheumatoidarthritis AT jalopatnikova tumornecrosisfactoramembraneboundandsolublereceptorsinnormandinrheumatoidarthritis AT svsennikov tumornecrosisfactoramembraneboundandsolublereceptorsinnormandinrheumatoidarthritis
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TUMOR NECROSIS FACTOR-α MEMBRANE-BOUND AND SOLUBLE RECEPTORS IN NORM AND IN RHEUMATOID ARTHRITIS

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