Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer
While many treatments for prostate cancer suppress the androgen receptor it becomes reactivated during disease progression. Here, the authors show that a KLF5 transcriptional programme is also activated during treatment and promotes migration and the appearance of a basal cell phenotype.
Guardado en:
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/0d96a02002f9414c84ce1f8008d43a91 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:0d96a02002f9414c84ce1f8008d43a91 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:0d96a02002f9414c84ce1f8008d43a912021-11-08T11:11:02ZOpposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer10.1038/s41467-021-26612-12041-1723https://doaj.org/article/0d96a02002f9414c84ce1f8008d43a912021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26612-1https://doaj.org/toc/2041-1723While many treatments for prostate cancer suppress the androgen receptor it becomes reactivated during disease progression. Here, the authors show that a KLF5 transcriptional programme is also activated during treatment and promotes migration and the appearance of a basal cell phenotype.Meixia CheAashi ChaturvediSarah A. MunroSamuel P. PitzenAlex LingWeijie ZhangJosh MentzerSheng-Yu KuLoredana PucaYanyun ZhuAndries M. BergmanTesa M. SeversonColleen ForsterYuzhen LiuJacob HildebrandMark DanielTing-You WangLuke A. SelthTheresa HickeyAmina ZoubeidiMartin GleaveRohan BarejaAndrea SbonerWayne TilleyJason S. CarrollWinston TanManish KohliRendong YangAndrew C. HsiehPaari MuruganWilbert ZwartHimisha BeltranR. Stephanie HuangScott M. DehmNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Science Q |
spellingShingle |
Science Q Meixia Che Aashi Chaturvedi Sarah A. Munro Samuel P. Pitzen Alex Ling Weijie Zhang Josh Mentzer Sheng-Yu Ku Loredana Puca Yanyun Zhu Andries M. Bergman Tesa M. Severson Colleen Forster Yuzhen Liu Jacob Hildebrand Mark Daniel Ting-You Wang Luke A. Selth Theresa Hickey Amina Zoubeidi Martin Gleave Rohan Bareja Andrea Sboner Wayne Tilley Jason S. Carroll Winston Tan Manish Kohli Rendong Yang Andrew C. Hsieh Paari Murugan Wilbert Zwart Himisha Beltran R. Stephanie Huang Scott M. Dehm Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer |
description |
While many treatments for prostate cancer suppress the androgen receptor it becomes reactivated during disease progression. Here, the authors show that a KLF5 transcriptional programme is also activated during treatment and promotes migration and the appearance of a basal cell phenotype. |
format |
article |
author |
Meixia Che Aashi Chaturvedi Sarah A. Munro Samuel P. Pitzen Alex Ling Weijie Zhang Josh Mentzer Sheng-Yu Ku Loredana Puca Yanyun Zhu Andries M. Bergman Tesa M. Severson Colleen Forster Yuzhen Liu Jacob Hildebrand Mark Daniel Ting-You Wang Luke A. Selth Theresa Hickey Amina Zoubeidi Martin Gleave Rohan Bareja Andrea Sboner Wayne Tilley Jason S. Carroll Winston Tan Manish Kohli Rendong Yang Andrew C. Hsieh Paari Murugan Wilbert Zwart Himisha Beltran R. Stephanie Huang Scott M. Dehm |
author_facet |
Meixia Che Aashi Chaturvedi Sarah A. Munro Samuel P. Pitzen Alex Ling Weijie Zhang Josh Mentzer Sheng-Yu Ku Loredana Puca Yanyun Zhu Andries M. Bergman Tesa M. Severson Colleen Forster Yuzhen Liu Jacob Hildebrand Mark Daniel Ting-You Wang Luke A. Selth Theresa Hickey Amina Zoubeidi Martin Gleave Rohan Bareja Andrea Sboner Wayne Tilley Jason S. Carroll Winston Tan Manish Kohli Rendong Yang Andrew C. Hsieh Paari Murugan Wilbert Zwart Himisha Beltran R. Stephanie Huang Scott M. Dehm |
author_sort |
Meixia Che |
title |
Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer |
title_short |
Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer |
title_full |
Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer |
title_fullStr |
Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer |
title_full_unstemmed |
Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer |
title_sort |
opposing transcriptional programs of klf5 and ar emerge during therapy for advanced prostate cancer |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/0d96a02002f9414c84ce1f8008d43a91 |
work_keys_str_mv |
AT meixiache opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT aashichaturvedi opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT sarahamunro opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT samuelppitzen opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT alexling opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT weijiezhang opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT joshmentzer opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT shengyuku opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT loredanapuca opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT yanyunzhu opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT andriesmbergman opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT tesamseverson opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT colleenforster opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT yuzhenliu opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT jacobhildebrand opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT markdaniel opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT tingyouwang opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT lukeaselth opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT theresahickey opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT aminazoubeidi opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT martingleave opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT rohanbareja opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT andreasboner opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT waynetilley opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT jasonscarroll opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT winstontan opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT manishkohli opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT rendongyang opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT andrewchsieh opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT paarimurugan opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT wilbertzwart opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT himishabeltran opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT rstephaniehuang opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer AT scottmdehm opposingtranscriptionalprogramsofklf5andaremergeduringtherapyforadvancedprostatecancer |
_version_ |
1718442306084798464 |