Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer

Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer

While many treatments for prostate cancer suppress the androgen receptor it becomes reactivated during disease progression. Here, the authors show that a KLF5 transcriptional programme is also activated during treatment and promotes migration and the appearance of a basal cell phenotype.

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Autores principales: Meixia Che, Aashi Chaturvedi, Sarah A. Munro, Samuel P. Pitzen, Alex Ling, Weijie Zhang, Josh Mentzer, Sheng-Yu Ku, Loredana Puca, Yanyun Zhu, Andries M. Bergman, Tesa M. Severson, Colleen Forster, Yuzhen Liu, Jacob Hildebrand, Mark Daniel, Ting-You Wang, Luke A. Selth, Theresa Hickey, Amina Zoubeidi, Martin Gleave, Rohan Bareja, Andrea Sboner, Wayne Tilley, Jason S. Carroll, Winston Tan, Manish Kohli, Rendong Yang, Andrew C. Hsieh, Paari Murugan, Wilbert Zwart, Himisha Beltran, R. Stephanie Huang, Scott M. Dehm
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/0d96a02002f9414c84ce1f8008d43a91
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spelling oai:doaj.org-article:0d96a02002f9414c84ce1f8008d43a912021-11-08T11:11:02ZOpposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer10.1038/s41467-021-26612-12041-1723https://doaj.org/article/0d96a02002f9414c84ce1f8008d43a912021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26612-1https://doaj.org/toc/2041-1723While many treatments for prostate cancer suppress the androgen receptor it becomes reactivated during disease progression. Here, the authors show that a KLF5 transcriptional programme is also activated during treatment and promotes migration and the appearance of a basal cell phenotype.Meixia CheAashi ChaturvediSarah A. MunroSamuel P. PitzenAlex LingWeijie ZhangJosh MentzerSheng-Yu KuLoredana PucaYanyun ZhuAndries M. BergmanTesa M. SeversonColleen ForsterYuzhen LiuJacob HildebrandMark DanielTing-You WangLuke A. SelthTheresa HickeyAmina ZoubeidiMartin GleaveRohan BarejaAndrea SbonerWayne TilleyJason S. CarrollWinston TanManish KohliRendong YangAndrew C. HsiehPaari MuruganWilbert ZwartHimisha BeltranR. Stephanie HuangScott M. DehmNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Meixia Che
Aashi Chaturvedi
Sarah A. Munro
Samuel P. Pitzen
Alex Ling
Weijie Zhang
Josh Mentzer
Sheng-Yu Ku
Loredana Puca
Yanyun Zhu
Andries M. Bergman
Tesa M. Severson
Colleen Forster
Yuzhen Liu
Jacob Hildebrand
Mark Daniel
Ting-You Wang
Luke A. Selth
Theresa Hickey
Amina Zoubeidi
Martin Gleave
Rohan Bareja
Andrea Sboner
Wayne Tilley
Jason S. Carroll
Winston Tan
Manish Kohli
Rendong Yang
Andrew C. Hsieh
Paari Murugan
Wilbert Zwart
Himisha Beltran
R. Stephanie Huang
Scott M. Dehm
Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer
description While many treatments for prostate cancer suppress the androgen receptor it becomes reactivated during disease progression. Here, the authors show that a KLF5 transcriptional programme is also activated during treatment and promotes migration and the appearance of a basal cell phenotype.
format article
author Meixia Che
Aashi Chaturvedi
Sarah A. Munro
Samuel P. Pitzen
Alex Ling
Weijie Zhang
Josh Mentzer
Sheng-Yu Ku
Loredana Puca
Yanyun Zhu
Andries M. Bergman
Tesa M. Severson
Colleen Forster
Yuzhen Liu
Jacob Hildebrand
Mark Daniel
Ting-You Wang
Luke A. Selth
Theresa Hickey
Amina Zoubeidi
Martin Gleave
Rohan Bareja
Andrea Sboner
Wayne Tilley
Jason S. Carroll
Winston Tan
Manish Kohli
Rendong Yang
Andrew C. Hsieh
Paari Murugan
Wilbert Zwart
Himisha Beltran
R. Stephanie Huang
Scott M. Dehm
author_facet Meixia Che
Aashi Chaturvedi
Sarah A. Munro
Samuel P. Pitzen
Alex Ling
Weijie Zhang
Josh Mentzer
Sheng-Yu Ku
Loredana Puca
Yanyun Zhu
Andries M. Bergman
Tesa M. Severson
Colleen Forster
Yuzhen Liu
Jacob Hildebrand
Mark Daniel
Ting-You Wang
Luke A. Selth
Theresa Hickey
Amina Zoubeidi
Martin Gleave
Rohan Bareja
Andrea Sboner
Wayne Tilley
Jason S. Carroll
Winston Tan
Manish Kohli
Rendong Yang
Andrew C. Hsieh
Paari Murugan
Wilbert Zwart
Himisha Beltran
R. Stephanie Huang
Scott M. Dehm
author_sort Meixia Che
title Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer
title_short Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer
title_full Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer
title_fullStr Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer
title_full_unstemmed Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer
title_sort opposing transcriptional programs of klf5 and ar emerge during therapy for advanced prostate cancer
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/0d96a02002f9414c84ce1f8008d43a91
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