Morphofunctional characteristic of gastric adipocytes in patients with type 2 diabetes mellitus

Aim. To measure gastrointestinal hormones in plasma, evaluate morphofunctional state of G- and beta-cells in patients with gastric pathology and concomitanttype 2 diabetes mellitus (DM2). Materials and methods. A total of 84 patients with gastric ulcer (GU) and chronic gastritis (CG) were availabl...

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Autores principales:	Ashot Musaelovich Mkrtumyan, I V Maev, K I Bairova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2009
Materias:	apudocytes cytokines gastritis gastric ulcer somatostatin Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/0d96b7988e264faba9383296fe26145f
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spelling	oai:doaj.org-article:0d96b7988e264faba9383296fe26145f2021-11-14T09:00:13ZMorphofunctional characteristic of gastric adipocytes in patients with type 2 diabetes mellitus2072-03512072-037810.14341/2072-0351-5397https://doaj.org/article/0d96b7988e264faba9383296fe26145f2009-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5397https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To measure gastrointestinal hormones in plasma, evaluate morphofunctional state of G- and beta-cells in patients with gastric pathology and concomitanttype 2 diabetes mellitus (DM2). Materials and methods. A total of 84 patients with gastric ulcer (GU) and chronic gastritis (CG) were available for observation including 46 with DM2.Semi-quantitative evaluation of stomach infection by H.pylori. was performed by a histological method. Stained G- and beta-cells were counted under 400xmagnification in 10 fields of vision for each medicinal preparation used in the study. Chromogranin A, somatostatin, and gastrin were detected by immunohistochemicalmethods, gastrin-17 and somatostatin-14 by the respective immunoassays. Control group comprised 10 practically healthy volunteers. Results. Patients with combined GU (or CG) and DM2 pathology had smaller density of G- and beta-cells, lower plasma gastrin and somatostatin levelsthan those without DM2 (pAshot Musaelovich MkrtumyanI V MaevK I BairovaEndocrinology Research Centrearticleapudocytescytokinesgastritisgastric ulcersomatostatinNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 12, Iss 2, Pp 46-50 (2009)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	apudocytes cytokines gastritis gastric ulcer somatostatin Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	apudocytes cytokines gastritis gastric ulcer somatostatin Nutritional diseases. Deficiency diseases RC620-627 Ashot Musaelovich Mkrtumyan I V Maev K I Bairova Morphofunctional characteristic of gastric adipocytes in patients with type 2 diabetes mellitus
description	Aim. To measure gastrointestinal hormones in plasma, evaluate morphofunctional state of G- and beta-cells in patients with gastric pathology and concomitanttype 2 diabetes mellitus (DM2). Materials and methods. A total of 84 patients with gastric ulcer (GU) and chronic gastritis (CG) were available for observation including 46 with DM2.Semi-quantitative evaluation of stomach infection by H.pylori. was performed by a histological method. Stained G- and beta-cells were counted under 400xmagnification in 10 fields of vision for each medicinal preparation used in the study. Chromogranin A, somatostatin, and gastrin were detected by immunohistochemicalmethods, gastrin-17 and somatostatin-14 by the respective immunoassays. Control group comprised 10 practically healthy volunteers. Results. Patients with combined GU (or CG) and DM2 pathology had smaller density of G- and beta-cells, lower plasma gastrin and somatostatin levelsthan those without DM2 (p
format	article
author	Ashot Musaelovich Mkrtumyan I V Maev K I Bairova
author_facet	Ashot Musaelovich Mkrtumyan I V Maev K I Bairova
author_sort	Ashot Musaelovich Mkrtumyan
title	Morphofunctional characteristic of gastric adipocytes in patients with type 2 diabetes mellitus
title_short	Morphofunctional characteristic of gastric adipocytes in patients with type 2 diabetes mellitus
title_full	Morphofunctional characteristic of gastric adipocytes in patients with type 2 diabetes mellitus
title_fullStr	Morphofunctional characteristic of gastric adipocytes in patients with type 2 diabetes mellitus
title_full_unstemmed	Morphofunctional characteristic of gastric adipocytes in patients with type 2 diabetes mellitus
title_sort	morphofunctional characteristic of gastric adipocytes in patients with type 2 diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2009
url	https://doaj.org/article/0d96b7988e264faba9383296fe26145f
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_version_	1718429632109215744

Morphofunctional characteristic of gastric adipocytes in patients with type 2 diabetes mellitus

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