Vasculogenic mimicry formation in EBV-associated epithelial malignancies

EBV latent infection contributes to the pathogenesis of epithelial malignancies by inducing angiogenesis. Here, the authors show EBV promotes vasculogenic mimicry in EBV associated epithelial cancers via AKT/HIF-1α pathway and combination therapy of HIF-1α and VEGF reduces tumour growth.

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Autores principales:	Tong Xiang, Yu-Xin Lin, Wenlong Ma, Hao-Jiong Zhang, Ke-Ming Chen, Gui-Ping He, Xiao Zhang, Miao Xu, Qi-Sheng Feng, Ming-Yuan Chen, Mu-Sheng Zeng, Yi-Xin Zeng, Lin Feng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0d9ba9a918d94d2c9e3a1eb930ec691b
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spelling	oai:doaj.org-article:0d9ba9a918d94d2c9e3a1eb930ec691b2021-12-02T17:32:44ZVasculogenic mimicry formation in EBV-associated epithelial malignancies10.1038/s41467-018-07308-52041-1723https://doaj.org/article/0d9ba9a918d94d2c9e3a1eb930ec691b2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07308-5https://doaj.org/toc/2041-1723EBV latent infection contributes to the pathogenesis of epithelial malignancies by inducing angiogenesis. Here, the authors show EBV promotes vasculogenic mimicry in EBV associated epithelial cancers via AKT/HIF-1α pathway and combination therapy of HIF-1α and VEGF reduces tumour growth.Tong XiangYu-Xin LinWenlong MaHao-Jiong ZhangKe-Ming ChenGui-Ping HeXiao ZhangMiao XuQi-Sheng FengMing-Yuan ChenMu-Sheng ZengYi-Xin ZengLin FengNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tong Xiang Yu-Xin Lin Wenlong Ma Hao-Jiong Zhang Ke-Ming Chen Gui-Ping He Xiao Zhang Miao Xu Qi-Sheng Feng Ming-Yuan Chen Mu-Sheng Zeng Yi-Xin Zeng Lin Feng Vasculogenic mimicry formation in EBV-associated epithelial malignancies
description	EBV latent infection contributes to the pathogenesis of epithelial malignancies by inducing angiogenesis. Here, the authors show EBV promotes vasculogenic mimicry in EBV associated epithelial cancers via AKT/HIF-1α pathway and combination therapy of HIF-1α and VEGF reduces tumour growth.
format	article
author	Tong Xiang Yu-Xin Lin Wenlong Ma Hao-Jiong Zhang Ke-Ming Chen Gui-Ping He Xiao Zhang Miao Xu Qi-Sheng Feng Ming-Yuan Chen Mu-Sheng Zeng Yi-Xin Zeng Lin Feng
author_facet	Tong Xiang Yu-Xin Lin Wenlong Ma Hao-Jiong Zhang Ke-Ming Chen Gui-Ping He Xiao Zhang Miao Xu Qi-Sheng Feng Ming-Yuan Chen Mu-Sheng Zeng Yi-Xin Zeng Lin Feng
author_sort	Tong Xiang
title	Vasculogenic mimicry formation in EBV-associated epithelial malignancies
title_short	Vasculogenic mimicry formation in EBV-associated epithelial malignancies
title_full	Vasculogenic mimicry formation in EBV-associated epithelial malignancies
title_fullStr	Vasculogenic mimicry formation in EBV-associated epithelial malignancies
title_full_unstemmed	Vasculogenic mimicry formation in EBV-associated epithelial malignancies
title_sort	vasculogenic mimicry formation in ebv-associated epithelial malignancies
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0d9ba9a918d94d2c9e3a1eb930ec691b
work_keys_str_mv	AT tongxiang vasculogenicmimicryformationinebvassociatedepithelialmalignancies AT yuxinlin vasculogenicmimicryformationinebvassociatedepithelialmalignancies AT wenlongma vasculogenicmimicryformationinebvassociatedepithelialmalignancies AT haojiongzhang vasculogenicmimicryformationinebvassociatedepithelialmalignancies AT kemingchen vasculogenicmimicryformationinebvassociatedepithelialmalignancies AT guipinghe vasculogenicmimicryformationinebvassociatedepithelialmalignancies AT xiaozhang vasculogenicmimicryformationinebvassociatedepithelialmalignancies AT miaoxu vasculogenicmimicryformationinebvassociatedepithelialmalignancies AT qishengfeng vasculogenicmimicryformationinebvassociatedepithelialmalignancies AT mingyuanchen vasculogenicmimicryformationinebvassociatedepithelialmalignancies AT mushengzeng vasculogenicmimicryformationinebvassociatedepithelialmalignancies AT yixinzeng vasculogenicmimicryformationinebvassociatedepithelialmalignancies AT linfeng vasculogenicmimicryformationinebvassociatedepithelialmalignancies
_version_	1718380167372472320

Vasculogenic mimicry formation in EBV-associated epithelial malignancies

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