A central mechanism enhances pain perception of noxious thermal stimulus changes

Abstract Pain perception temporarily exaggerates abrupt thermal stimulus changes revealing a mechanism for nociceptive temporal contrast enhancement (TCE). Although the mechanism is unknown, a non-linear model with perceptual feedback accurately simulates the phenomenon. Here we test if a mechanism...

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Autores principales:	B. Petre, P. Tetreault, V. A. Mathur, M. W. Schurgin, J. Y. Chiao, L. Huang, A. V. Apkarian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0d9c56a73e5b40188c38feb489717da3
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spelling	oai:doaj.org-article:0d9c56a73e5b40188c38feb489717da32021-12-02T12:32:24ZA central mechanism enhances pain perception of noxious thermal stimulus changes10.1038/s41598-017-04009-92045-2322https://doaj.org/article/0d9c56a73e5b40188c38feb489717da32017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04009-9https://doaj.org/toc/2045-2322Abstract Pain perception temporarily exaggerates abrupt thermal stimulus changes revealing a mechanism for nociceptive temporal contrast enhancement (TCE). Although the mechanism is unknown, a non-linear model with perceptual feedback accurately simulates the phenomenon. Here we test if a mechanism in the central nervous system underlies thermal TCE. Our model successfully predicted an optimal stimulus, incorporating a transient temperature offset (step-up/step-down), with maximal TCE, resulting in psychophysically verified large decrements in pain response (“offset-analgesia”; mean analgesia: 85%, n = 20 subjects). Next, this stimulus was delivered using two thermodes, one delivering the longer duration baseline temperature pulse and the other superimposing a short higher temperature pulse. The two stimuli were applied simultaneously either near or far on the same arm, or on opposite arms. Spatial separation across multiple peripheral receptive fields ensures the composite stimulus timecourse is first reconstituted in the central nervous system. Following ipsilateral stimulus cessation on the high temperature thermode, but before cessation of the low temperature stimulus properties of TCE were observed both for individual subjects and in group-mean responses. This demonstrates a central integration mechanism is sufficient to evoke painful thermal TCE, an essential step in transforming transient afferent nociceptive signals into a stable pain perception.B. PetreP. TetreaultV. A. MathurM. W. SchurginJ. Y. ChiaoL. HuangA. V. ApkarianNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q B. Petre P. Tetreault V. A. Mathur M. W. Schurgin J. Y. Chiao L. Huang A. V. Apkarian A central mechanism enhances pain perception of noxious thermal stimulus changes
description	Abstract Pain perception temporarily exaggerates abrupt thermal stimulus changes revealing a mechanism for nociceptive temporal contrast enhancement (TCE). Although the mechanism is unknown, a non-linear model with perceptual feedback accurately simulates the phenomenon. Here we test if a mechanism in the central nervous system underlies thermal TCE. Our model successfully predicted an optimal stimulus, incorporating a transient temperature offset (step-up/step-down), with maximal TCE, resulting in psychophysically verified large decrements in pain response (“offset-analgesia”; mean analgesia: 85%, n = 20 subjects). Next, this stimulus was delivered using two thermodes, one delivering the longer duration baseline temperature pulse and the other superimposing a short higher temperature pulse. The two stimuli were applied simultaneously either near or far on the same arm, or on opposite arms. Spatial separation across multiple peripheral receptive fields ensures the composite stimulus timecourse is first reconstituted in the central nervous system. Following ipsilateral stimulus cessation on the high temperature thermode, but before cessation of the low temperature stimulus properties of TCE were observed both for individual subjects and in group-mean responses. This demonstrates a central integration mechanism is sufficient to evoke painful thermal TCE, an essential step in transforming transient afferent nociceptive signals into a stable pain perception.
format	article
author	B. Petre P. Tetreault V. A. Mathur M. W. Schurgin J. Y. Chiao L. Huang A. V. Apkarian
author_facet	B. Petre P. Tetreault V. A. Mathur M. W. Schurgin J. Y. Chiao L. Huang A. V. Apkarian
author_sort	B. Petre
title	A central mechanism enhances pain perception of noxious thermal stimulus changes
title_short	A central mechanism enhances pain perception of noxious thermal stimulus changes
title_full	A central mechanism enhances pain perception of noxious thermal stimulus changes
title_fullStr	A central mechanism enhances pain perception of noxious thermal stimulus changes
title_full_unstemmed	A central mechanism enhances pain perception of noxious thermal stimulus changes
title_sort	central mechanism enhances pain perception of noxious thermal stimulus changes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0d9c56a73e5b40188c38feb489717da3
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A central mechanism enhances pain perception of noxious thermal stimulus changes

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