Mechanotransductive cascade of Myo-II-dependent mesoderm and endoderm invaginations in embryo gastrulation

Mechanical signals regulate tissue differentiation but how this triggers downstream biochemical signals is unclear. Here, the authors place micro-magnets in theDrosophilaembryonic epithelia and show this triggers apical pulsations, in turn stabilizing Myosin-II, resulting in mesoderm invagination.

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Autores principales:	Démosthène Mitrossilis, Jens-Christian Röper, Damien Le Roy, Benjamin Driquez, Aude Michel, Christine Ménager, Gorky Shaw, Simon Le Denmat, Laurent Ranno, Frédéric Dumas-Bouchiat, Nora M. Dempsey, Emmanuel Farge
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0d9d6c9700fb45089a4837ff83f42617
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spelling	oai:doaj.org-article:0d9d6c9700fb45089a4837ff83f426172021-12-02T17:06:13ZMechanotransductive cascade of Myo-II-dependent mesoderm and endoderm invaginations in embryo gastrulation10.1038/ncomms138832041-1723https://doaj.org/article/0d9d6c9700fb45089a4837ff83f426172017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13883https://doaj.org/toc/2041-1723Mechanical signals regulate tissue differentiation but how this triggers downstream biochemical signals is unclear. Here, the authors place micro-magnets in theDrosophilaembryonic epithelia and show this triggers apical pulsations, in turn stabilizing Myosin-II, resulting in mesoderm invagination.Démosthène MitrossilisJens-Christian RöperDamien Le RoyBenjamin DriquezAude MichelChristine MénagerGorky ShawSimon Le DenmatLaurent RannoFrédéric Dumas-BouchiatNora M. DempseyEmmanuel FargeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Démosthène Mitrossilis Jens-Christian Röper Damien Le Roy Benjamin Driquez Aude Michel Christine Ménager Gorky Shaw Simon Le Denmat Laurent Ranno Frédéric Dumas-Bouchiat Nora M. Dempsey Emmanuel Farge Mechanotransductive cascade of Myo-II-dependent mesoderm and endoderm invaginations in embryo gastrulation
description	Mechanical signals regulate tissue differentiation but how this triggers downstream biochemical signals is unclear. Here, the authors place micro-magnets in theDrosophilaembryonic epithelia and show this triggers apical pulsations, in turn stabilizing Myosin-II, resulting in mesoderm invagination.
format	article
author	Démosthène Mitrossilis Jens-Christian Röper Damien Le Roy Benjamin Driquez Aude Michel Christine Ménager Gorky Shaw Simon Le Denmat Laurent Ranno Frédéric Dumas-Bouchiat Nora M. Dempsey Emmanuel Farge
author_facet	Démosthène Mitrossilis Jens-Christian Röper Damien Le Roy Benjamin Driquez Aude Michel Christine Ménager Gorky Shaw Simon Le Denmat Laurent Ranno Frédéric Dumas-Bouchiat Nora M. Dempsey Emmanuel Farge
author_sort	Démosthène Mitrossilis
title	Mechanotransductive cascade of Myo-II-dependent mesoderm and endoderm invaginations in embryo gastrulation
title_short	Mechanotransductive cascade of Myo-II-dependent mesoderm and endoderm invaginations in embryo gastrulation
title_full	Mechanotransductive cascade of Myo-II-dependent mesoderm and endoderm invaginations in embryo gastrulation
title_fullStr	Mechanotransductive cascade of Myo-II-dependent mesoderm and endoderm invaginations in embryo gastrulation
title_full_unstemmed	Mechanotransductive cascade of Myo-II-dependent mesoderm and endoderm invaginations in embryo gastrulation
title_sort	mechanotransductive cascade of myo-ii-dependent mesoderm and endoderm invaginations in embryo gastrulation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0d9d6c9700fb45089a4837ff83f42617
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Mechanotransductive cascade of Myo-II-dependent mesoderm and endoderm invaginations in embryo gastrulation

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