The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach
Abstract The M1 family of metalloproteases represents a large number of exopeptidases that cleave single amino acid residues from the N-terminus of peptide substrates. One member of this family that has been well studied is aminopeptidase N (APN), a multifunctional protease known to cleave biologica...
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Autores principales: | Shilvi Joshi, Lang Chen, Michael B. Winter, Yi-Lun Lin, Yang Yang, Mariya Shapovalova, Paige M. Smith, Chang Liu, Fang Li, Aaron M. LeBeau |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
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Materias: | |
Acceso en línea: | https://doaj.org/article/0da13595ddc84cff8dba8adb84bdbdf8 |
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