Efficacy of duloxetine compared with opioid for postoperative pain control following total knee arthroplasty.

<h4>Background</h4>The purpose of this study was to assess the efficacy of duloxetine as an alternative to opioid treatment for postoperative pain management following total knee arthroplasty (TKA).<h4>Methods</h4>Among 944 patients, 290 (30.7%) of patients received opioid or...

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Autores principales:	Man Soo Kim, In Jun Koh, Keun Young Choi, Sung Cheol Yang, Yong In
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0da1c6d2f5ac47feb1413462f3281ba6
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spelling	oai:doaj.org-article:0da1c6d2f5ac47feb1413462f3281ba62021-12-02T20:15:40ZEfficacy of duloxetine compared with opioid for postoperative pain control following total knee arthroplasty.1932-620310.1371/journal.pone.0253641https://doaj.org/article/0da1c6d2f5ac47feb1413462f3281ba62021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253641https://doaj.org/toc/1932-6203<h4>Background</h4>The purpose of this study was to assess the efficacy of duloxetine as an alternative to opioid treatment for postoperative pain management following total knee arthroplasty (TKA).<h4>Methods</h4>Among 944 patients, 290 (30.7%) of patients received opioid or duloxetine for pain control for 6 weeks when the pain Visual Analogue Scale (VAS) score was greater than 4 out of 10 at the time of discharge. 121 patients in the Opioid group and 118 in the Duloxetine group were followed up for more than one year. Preoperative and postoperative patient reported outcome measures (pain VAS score, Western Ontario and McMaster Universities OA Index (WOMAC) score were compared. The rate of further drug prescription (opioid or duloxetine) after 6 weeks of first prescription, 30-day readmission rate, and side effects were also investigated.<h4>Results</h4>There was no significant difference in pain VAS score, WOMAC Pain and Function score, at each time point between before and after surgery (all p>0.05). Fifteen (9.8%) patients in the opioid group and six (4.4%) patients in the duloxetine group were prescribed additional medication after first 6 weeks, showing no significant (p>0.05) difference in proportion. The 30-day readmission rate and the incidence of side effects were also similar (all p>0.05). There was no difference in the incidence of side effects between the two groups (p>0.05).<h4>Conclusion</h4>Duloxetine and opioid did not show any difference in pain control, function, and side effects for up to one year after TKA. Although large-scale randomized controlled trials are still required to further confirm the side effects of duloxetine, it can be considered as an alternative to opioid for postoperative pain control following TKA.Man Soo KimIn Jun KohKeun Young ChoiSung Cheol YangYong InPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0253641 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Man Soo Kim In Jun Koh Keun Young Choi Sung Cheol Yang Yong In Efficacy of duloxetine compared with opioid for postoperative pain control following total knee arthroplasty.
description	<h4>Background</h4>The purpose of this study was to assess the efficacy of duloxetine as an alternative to opioid treatment for postoperative pain management following total knee arthroplasty (TKA).<h4>Methods</h4>Among 944 patients, 290 (30.7%) of patients received opioid or duloxetine for pain control for 6 weeks when the pain Visual Analogue Scale (VAS) score was greater than 4 out of 10 at the time of discharge. 121 patients in the Opioid group and 118 in the Duloxetine group were followed up for more than one year. Preoperative and postoperative patient reported outcome measures (pain VAS score, Western Ontario and McMaster Universities OA Index (WOMAC) score were compared. The rate of further drug prescription (opioid or duloxetine) after 6 weeks of first prescription, 30-day readmission rate, and side effects were also investigated.<h4>Results</h4>There was no significant difference in pain VAS score, WOMAC Pain and Function score, at each time point between before and after surgery (all p>0.05). Fifteen (9.8%) patients in the opioid group and six (4.4%) patients in the duloxetine group were prescribed additional medication after first 6 weeks, showing no significant (p>0.05) difference in proportion. The 30-day readmission rate and the incidence of side effects were also similar (all p>0.05). There was no difference in the incidence of side effects between the two groups (p>0.05).<h4>Conclusion</h4>Duloxetine and opioid did not show any difference in pain control, function, and side effects for up to one year after TKA. Although large-scale randomized controlled trials are still required to further confirm the side effects of duloxetine, it can be considered as an alternative to opioid for postoperative pain control following TKA.
format	article
author	Man Soo Kim In Jun Koh Keun Young Choi Sung Cheol Yang Yong In
author_facet	Man Soo Kim In Jun Koh Keun Young Choi Sung Cheol Yang Yong In
author_sort	Man Soo Kim
title	Efficacy of duloxetine compared with opioid for postoperative pain control following total knee arthroplasty.
title_short	Efficacy of duloxetine compared with opioid for postoperative pain control following total knee arthroplasty.
title_full	Efficacy of duloxetine compared with opioid for postoperative pain control following total knee arthroplasty.
title_fullStr	Efficacy of duloxetine compared with opioid for postoperative pain control following total knee arthroplasty.
title_full_unstemmed	Efficacy of duloxetine compared with opioid for postoperative pain control following total knee arthroplasty.
title_sort	efficacy of duloxetine compared with opioid for postoperative pain control following total knee arthroplasty.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0da1c6d2f5ac47feb1413462f3281ba6
work_keys_str_mv	AT mansookim efficacyofduloxetinecomparedwithopioidforpostoperativepaincontrolfollowingtotalkneearthroplasty AT injunkoh efficacyofduloxetinecomparedwithopioidforpostoperativepaincontrolfollowingtotalkneearthroplasty AT keunyoungchoi efficacyofduloxetinecomparedwithopioidforpostoperativepaincontrolfollowingtotalkneearthroplasty AT sungcheolyang efficacyofduloxetinecomparedwithopioidforpostoperativepaincontrolfollowingtotalkneearthroplasty AT yongin efficacyofduloxetinecomparedwithopioidforpostoperativepaincontrolfollowingtotalkneearthroplasty
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Efficacy of duloxetine compared with opioid for postoperative pain control following total knee arthroplasty.

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