Potential role of lampalizumab for treatment of geographic atrophy

Potential role of lampalizumab for treatment of geographic atrophy

William Rhoades, Drew Dickson, Diana V Do Truhlsen Eye Institute, Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE, USA Abstract: The purpose of this article is to review the pathways underlying age-related macular degeneration and potential therap...

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Autores principales: Rhoades W, Dickson D, Do DV
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
Materias:
Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/0da29c5eb2dc4abdb05e965fd4783a15
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spelling oai:doaj.org-article:0da29c5eb2dc4abdb05e965fd4783a152021-12-02T05:00:09ZPotential role of lampalizumab for treatment of geographic atrophy1177-5483https://doaj.org/article/0da29c5eb2dc4abdb05e965fd4783a152015-06-01T00:00:00Zhttp://www.dovepress.com/potential-role-of-lampalizumab-for-treatment-ofnbspgeographic-atrophy-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483William Rhoades, Drew Dickson, Diana V Do Truhlsen Eye Institute, Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE, USA Abstract: The purpose of this article is to review the pathways underlying age-related macular degeneration and potential therapeutic targets, focusing on the complement pathway and the recent MAHALO Phase II trial of the investigational drug lampalizumab. This trial was the first to have shown positive results for the treatment of geographic atrophy in age-related macular degeneration. It has potential as a future treatment, and is currently undergoing a Phase III trial. Keywords: age-related macular degeneration, complement inhibition, AMDRhoades WDickson DDo DVDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 1049-1056 (2015)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Rhoades W
Dickson D
Do DV
Potential role of lampalizumab for treatment of geographic atrophy
description William Rhoades, Drew Dickson, Diana V Do Truhlsen Eye Institute, Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE, USA Abstract: The purpose of this article is to review the pathways underlying age-related macular degeneration and potential therapeutic targets, focusing on the complement pathway and the recent MAHALO Phase II trial of the investigational drug lampalizumab. This trial was the first to have shown positive results for the treatment of geographic atrophy in age-related macular degeneration. It has potential as a future treatment, and is currently undergoing a Phase III trial. Keywords: age-related macular degeneration, complement inhibition, AMD
format article
author Rhoades W
Dickson D
Do DV
author_facet Rhoades W
Dickson D
Do DV
author_sort Rhoades W
title Potential role of lampalizumab for treatment of geographic atrophy
title_short Potential role of lampalizumab for treatment of geographic atrophy
title_full Potential role of lampalizumab for treatment of geographic atrophy
title_fullStr Potential role of lampalizumab for treatment of geographic atrophy
title_full_unstemmed Potential role of lampalizumab for treatment of geographic atrophy
title_sort potential role of lampalizumab for treatment of geographic atrophy
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/0da29c5eb2dc4abdb05e965fd4783a15
work_keys_str_mv AT rhoadesw potentialroleoflampalizumabfortreatmentofnbspgeographicatrophy
AT dicksond potentialroleoflampalizumabfortreatmentofnbspgeographicatrophy
AT dodv potentialroleoflampalizumabfortreatmentofnbspgeographicatrophy
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