Massive choroidal hemorrhage after intravitreal administration of bevacizumab (Avastin®) for AMD followed by controlateral sympathetic ophthalmia

Dimitrios Brouzas, Chryssanthi Koutsandrea, Marilita Moschos, Spiros Papadimitriou, Ioannis Ladas, Michael Apostolopoulos1st Eye Department , University of Athens, Athens, GreecePurpose: To report a severe ocular complication initiated ten days after intravitreal administration of bevacizumab (Avast...

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Autores principales: Dimitrios Brouzas, Chryssanthi Koutsandrea, Marilita Moschos, et al
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Publicado: Dove Medical Press 2009
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spelling oai:doaj.org-article:0da36a6946634506ba4d208781152ad72021-12-02T01:41:36ZMassive choroidal hemorrhage after intravitreal administration of bevacizumab (Avastin®) for AMD followed by controlateral sympathetic ophthalmia1177-54671177-5483https://doaj.org/article/0da36a6946634506ba4d208781152ad72009-08-01T00:00:00Zhttp://www.dovepress.com/massive-choroidal-hemorrhage-after-intravitreal-administration-of-beva-a3408https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Dimitrios Brouzas, Chryssanthi Koutsandrea, Marilita Moschos, Spiros Papadimitriou, Ioannis Ladas, Michael Apostolopoulos1st Eye Department , University of Athens, Athens, GreecePurpose: To report a severe ocular complication initiated ten days after intravitreal administration of bevacizumab (Avastin®), in a patient with exudative age-related macular degeneration (AMD).Patients and method: Case report.Results: Ten days after intravitreal injection of 1.25 mg Avastin®, the patient manifested acute loss of vision with excruciating pain. An extensive choroidal detachment was evident in close contact with the lens, which necessitated an emergency sclerotomy with reconstruction of the anterior chamber. Four months later, the eye proceeded to phthisis bulbi. Five months after the injection, the patient complained of mild pain, photophobia, and visual acuity deterioration from the fellow eye. The diagnosis of sympathetic ophthalmia was suggested and treated with intravitreal injections of triamcinolone acetonide every three months with good response, complicated by elevation of intraocular pressure which we managed with Ahmet valve implantation.Conclusion: Serious ocular complications after intravitreal of Avastin® can not be excluded, including massive choroidal hemorrhage and sympathetic ophthalmia of the fellow eye.Keywords: Avastin® complication, intravitreal injection, choroidal detachment, Phthisis bulbi, sympathetic ophthalmia Dimitrios BrouzasChryssanthi KoutsandreaMarilita Moschoset alDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2009, Iss default, Pp 457-459 (2009)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Dimitrios Brouzas
Chryssanthi Koutsandrea
Marilita Moschos
et al
Massive choroidal hemorrhage after intravitreal administration of bevacizumab (Avastin®) for AMD followed by controlateral sympathetic ophthalmia
description Dimitrios Brouzas, Chryssanthi Koutsandrea, Marilita Moschos, Spiros Papadimitriou, Ioannis Ladas, Michael Apostolopoulos1st Eye Department , University of Athens, Athens, GreecePurpose: To report a severe ocular complication initiated ten days after intravitreal administration of bevacizumab (Avastin®), in a patient with exudative age-related macular degeneration (AMD).Patients and method: Case report.Results: Ten days after intravitreal injection of 1.25 mg Avastin®, the patient manifested acute loss of vision with excruciating pain. An extensive choroidal detachment was evident in close contact with the lens, which necessitated an emergency sclerotomy with reconstruction of the anterior chamber. Four months later, the eye proceeded to phthisis bulbi. Five months after the injection, the patient complained of mild pain, photophobia, and visual acuity deterioration from the fellow eye. The diagnosis of sympathetic ophthalmia was suggested and treated with intravitreal injections of triamcinolone acetonide every three months with good response, complicated by elevation of intraocular pressure which we managed with Ahmet valve implantation.Conclusion: Serious ocular complications after intravitreal of Avastin® can not be excluded, including massive choroidal hemorrhage and sympathetic ophthalmia of the fellow eye.Keywords: Avastin® complication, intravitreal injection, choroidal detachment, Phthisis bulbi, sympathetic ophthalmia
format article
author Dimitrios Brouzas
Chryssanthi Koutsandrea
Marilita Moschos
et al
author_facet Dimitrios Brouzas
Chryssanthi Koutsandrea
Marilita Moschos
et al
author_sort Dimitrios Brouzas
title Massive choroidal hemorrhage after intravitreal administration of bevacizumab (Avastin®) for AMD followed by controlateral sympathetic ophthalmia
title_short Massive choroidal hemorrhage after intravitreal administration of bevacizumab (Avastin®) for AMD followed by controlateral sympathetic ophthalmia
title_full Massive choroidal hemorrhage after intravitreal administration of bevacizumab (Avastin®) for AMD followed by controlateral sympathetic ophthalmia
title_fullStr Massive choroidal hemorrhage after intravitreal administration of bevacizumab (Avastin®) for AMD followed by controlateral sympathetic ophthalmia
title_full_unstemmed Massive choroidal hemorrhage after intravitreal administration of bevacizumab (Avastin®) for AMD followed by controlateral sympathetic ophthalmia
title_sort massive choroidal hemorrhage after intravitreal administration of bevacizumab (avastin®) for amd followed by controlateral sympathetic ophthalmia
publisher Dove Medical Press
publishDate 2009
url https://doaj.org/article/0da36a6946634506ba4d208781152ad7
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AT marilitamoschos massivechoroidalhemorrhageafterintravitrealadministrationofbevacizumabavastinampregforamdfollowedbycontrolateralsympatheticophthalmia
AT etal massivechoroidalhemorrhageafterintravitrealadministrationofbevacizumabavastinampregforamdfollowedbycontrolateralsympatheticophthalmia
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