Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus

Antibodies against dengue virus (DENV) can increase Zika virus (ZIKV) infectionin vitro, but their role in vivoremains largely unknown. Here, the authors show that pre-existing immunity from a 2.8 years earlier DENV infection does not affect ZIKV pathogenesis in macaques but instead shortens Zika vi...

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Autores principales:	Petraleigh Pantoja, Erick X. Pérez-Guzmán, Idia V. Rodríguez, Laura J. White, Olga González, Crisanta Serrano, Luis Giavedoni, Vida Hodara, Lorna Cruz, Teresa Arana, Melween I. Martínez, Mariah A. Hassert, James D. Brien, Amelia K. Pinto, Aravinda de Silva, Carlos A. Sariol
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0da3c5399a8a4c87b377fe65a7d69926
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spelling	oai:doaj.org-article:0da3c5399a8a4c87b377fe65a7d699262021-12-02T17:06:30ZZika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus10.1038/ncomms156742041-1723https://doaj.org/article/0da3c5399a8a4c87b377fe65a7d699262017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15674https://doaj.org/toc/2041-1723Antibodies against dengue virus (DENV) can increase Zika virus (ZIKV) infectionin vitro, but their role in vivoremains largely unknown. Here, the authors show that pre-existing immunity from a 2.8 years earlier DENV infection does not affect ZIKV pathogenesis in macaques but instead shortens Zika viremia.Petraleigh PantojaErick X. Pérez-GuzmánIdia V. RodríguezLaura J. WhiteOlga GonzálezCrisanta SerranoLuis GiavedoniVida HodaraLorna CruzTeresa AranaMelween I. MartínezMariah A. HassertJames D. BrienAmelia K. PintoAravinda de SilvaCarlos A. SariolNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Petraleigh Pantoja Erick X. Pérez-Guzmán Idia V. Rodríguez Laura J. White Olga González Crisanta Serrano Luis Giavedoni Vida Hodara Lorna Cruz Teresa Arana Melween I. Martínez Mariah A. Hassert James D. Brien Amelia K. Pinto Aravinda de Silva Carlos A. Sariol Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus
description	Antibodies against dengue virus (DENV) can increase Zika virus (ZIKV) infectionin vitro, but their role in vivoremains largely unknown. Here, the authors show that pre-existing immunity from a 2.8 years earlier DENV infection does not affect ZIKV pathogenesis in macaques but instead shortens Zika viremia.
format	article
author	Petraleigh Pantoja Erick X. Pérez-Guzmán Idia V. Rodríguez Laura J. White Olga González Crisanta Serrano Luis Giavedoni Vida Hodara Lorna Cruz Teresa Arana Melween I. Martínez Mariah A. Hassert James D. Brien Amelia K. Pinto Aravinda de Silva Carlos A. Sariol
author_facet	Petraleigh Pantoja Erick X. Pérez-Guzmán Idia V. Rodríguez Laura J. White Olga González Crisanta Serrano Luis Giavedoni Vida Hodara Lorna Cruz Teresa Arana Melween I. Martínez Mariah A. Hassert James D. Brien Amelia K. Pinto Aravinda de Silva Carlos A. Sariol
author_sort	Petraleigh Pantoja
title	Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus
title_short	Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus
title_full	Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus
title_fullStr	Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus
title_full_unstemmed	Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus
title_sort	zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0da3c5399a8a4c87b377fe65a7d69926
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Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus

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