Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress

Objective. Changes in the brain derived neurotrophic factor (BDNF) and glucocorticoid receptor (GR) expression in the prefrontal cortex (PFC) and hippocampus (HIP) are associated with psychiatric diseases and stress response. Chronic mild stress (CMS) may alter BDNF as well as GR levels in both the...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Osacka Jana, Koprdova Romana, Tillinger Andrej, Pirnik Zdenko, Kiss Alexander
Formato: article
Lenguaje:EN
Publicado: Sciendo 2021
Materias:
rat
Acceso en línea:https://doaj.org/article/0da3f6722b604d97a4296b06a4dd5406
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:0da3f6722b604d97a4296b06a4dd5406
record_format dspace
spelling oai:doaj.org-article:0da3f6722b604d97a4296b06a4dd54062021-12-02T17:22:47ZHaloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress1336-032910.2478/enr-2021-0016https://doaj.org/article/0da3f6722b604d97a4296b06a4dd54062021-07-01T00:00:00Zhttps://doi.org/10.2478/enr-2021-0016https://doaj.org/toc/1336-0329Objective. Changes in the brain derived neurotrophic factor (BDNF) and glucocorticoid receptor (GR) expression in the prefrontal cortex (PFC) and hippocampus (HIP) are associated with psychiatric diseases and stress response. Chronic mild stress (CMS) may alter BDNF as well as GR levels in both the PFC and the HIP. The aim of the present study was to find out whether chronic treatment with a typical antipsychotic haloperidol (HAL) and an atypical antipsychotic aripiprazole (ARI) may modify the CMS effect on the BDNF and GR expression in the above-mentioned structures.Osacka JanaKoprdova RomanaTillinger AndrejPirnik ZdenkoKiss AlexanderSciendoarticlebrain derived neurotrophic factorglucocorticoid receptorsc-fos-immunohisto-chemistryhaloperidolaripiprazoleprefrontal cortexhippocampusratDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 55, Iss 3, Pp 153-162 (2021)
institution DOAJ
collection DOAJ
language EN
topic brain derived neurotrophic factor
glucocorticoid receptors
c-fos-immunohisto-chemistry
haloperidol
aripiprazole
prefrontal cortex
hippocampus
rat
Diseases of the endocrine glands. Clinical endocrinology
RC648-665
spellingShingle brain derived neurotrophic factor
glucocorticoid receptors
c-fos-immunohisto-chemistry
haloperidol
aripiprazole
prefrontal cortex
hippocampus
rat
Diseases of the endocrine glands. Clinical endocrinology
RC648-665
Osacka Jana
Koprdova Romana
Tillinger Andrej
Pirnik Zdenko
Kiss Alexander
Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress
description Objective. Changes in the brain derived neurotrophic factor (BDNF) and glucocorticoid receptor (GR) expression in the prefrontal cortex (PFC) and hippocampus (HIP) are associated with psychiatric diseases and stress response. Chronic mild stress (CMS) may alter BDNF as well as GR levels in both the PFC and the HIP. The aim of the present study was to find out whether chronic treatment with a typical antipsychotic haloperidol (HAL) and an atypical antipsychotic aripiprazole (ARI) may modify the CMS effect on the BDNF and GR expression in the above-mentioned structures.
format article
author Osacka Jana
Koprdova Romana
Tillinger Andrej
Pirnik Zdenko
Kiss Alexander
author_facet Osacka Jana
Koprdova Romana
Tillinger Andrej
Pirnik Zdenko
Kiss Alexander
author_sort Osacka Jana
title Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress
title_short Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress
title_full Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress
title_fullStr Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress
title_full_unstemmed Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress
title_sort haloperidol and aripiprazole impact on the bdnf and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress
publisher Sciendo
publishDate 2021
url https://doaj.org/article/0da3f6722b604d97a4296b06a4dd5406
work_keys_str_mv AT osackajana haloperidolandaripiprazoleimpactonthebdnfandglucocorticoidreceptorlevelsintherathippocampusandprefrontalcortexeffectofthechronicmildstress
AT koprdovaromana haloperidolandaripiprazoleimpactonthebdnfandglucocorticoidreceptorlevelsintherathippocampusandprefrontalcortexeffectofthechronicmildstress
AT tillingerandrej haloperidolandaripiprazoleimpactonthebdnfandglucocorticoidreceptorlevelsintherathippocampusandprefrontalcortexeffectofthechronicmildstress
AT pirnikzdenko haloperidolandaripiprazoleimpactonthebdnfandglucocorticoidreceptorlevelsintherathippocampusandprefrontalcortexeffectofthechronicmildstress
AT kissalexander haloperidolandaripiprazoleimpactonthebdnfandglucocorticoidreceptorlevelsintherathippocampusandprefrontalcortexeffectofthechronicmildstress
_version_ 1718380951326687232