Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress
Objective. Changes in the brain derived neurotrophic factor (BDNF) and glucocorticoid receptor (GR) expression in the prefrontal cortex (PFC) and hippocampus (HIP) are associated with psychiatric diseases and stress response. Chronic mild stress (CMS) may alter BDNF as well as GR levels in both the...
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oai:doaj.org-article:0da3f6722b604d97a4296b06a4dd54062021-12-02T17:22:47ZHaloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress1336-032910.2478/enr-2021-0016https://doaj.org/article/0da3f6722b604d97a4296b06a4dd54062021-07-01T00:00:00Zhttps://doi.org/10.2478/enr-2021-0016https://doaj.org/toc/1336-0329Objective. Changes in the brain derived neurotrophic factor (BDNF) and glucocorticoid receptor (GR) expression in the prefrontal cortex (PFC) and hippocampus (HIP) are associated with psychiatric diseases and stress response. Chronic mild stress (CMS) may alter BDNF as well as GR levels in both the PFC and the HIP. The aim of the present study was to find out whether chronic treatment with a typical antipsychotic haloperidol (HAL) and an atypical antipsychotic aripiprazole (ARI) may modify the CMS effect on the BDNF and GR expression in the above-mentioned structures.Osacka JanaKoprdova RomanaTillinger AndrejPirnik ZdenkoKiss AlexanderSciendoarticlebrain derived neurotrophic factorglucocorticoid receptorsc-fos-immunohisto-chemistryhaloperidolaripiprazoleprefrontal cortexhippocampusratDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 55, Iss 3, Pp 153-162 (2021) |
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brain derived neurotrophic factor glucocorticoid receptors c-fos-immunohisto-chemistry haloperidol aripiprazole prefrontal cortex hippocampus rat Diseases of the endocrine glands. Clinical endocrinology RC648-665 |
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brain derived neurotrophic factor glucocorticoid receptors c-fos-immunohisto-chemistry haloperidol aripiprazole prefrontal cortex hippocampus rat Diseases of the endocrine glands. Clinical endocrinology RC648-665 Osacka Jana Koprdova Romana Tillinger Andrej Pirnik Zdenko Kiss Alexander Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress |
description |
Objective. Changes in the brain derived neurotrophic factor (BDNF) and glucocorticoid receptor (GR) expression in the prefrontal cortex (PFC) and hippocampus (HIP) are associated with psychiatric diseases and stress response. Chronic mild stress (CMS) may alter BDNF as well as GR levels in both the PFC and the HIP. The aim of the present study was to find out whether chronic treatment with a typical antipsychotic haloperidol (HAL) and an atypical antipsychotic aripiprazole (ARI) may modify the CMS effect on the BDNF and GR expression in the above-mentioned structures. |
format |
article |
author |
Osacka Jana Koprdova Romana Tillinger Andrej Pirnik Zdenko Kiss Alexander |
author_facet |
Osacka Jana Koprdova Romana Tillinger Andrej Pirnik Zdenko Kiss Alexander |
author_sort |
Osacka Jana |
title |
Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress |
title_short |
Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress |
title_full |
Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress |
title_fullStr |
Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress |
title_full_unstemmed |
Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress |
title_sort |
haloperidol and aripiprazole impact on the bdnf and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress |
publisher |
Sciendo |
publishDate |
2021 |
url |
https://doaj.org/article/0da3f6722b604d97a4296b06a4dd5406 |
work_keys_str_mv |
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