Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress

Objective. Changes in the brain derived neurotrophic factor (BDNF) and glucocorticoid receptor (GR) expression in the prefrontal cortex (PFC) and hippocampus (HIP) are associated with psychiatric diseases and stress response. Chronic mild stress (CMS) may alter BDNF as well as GR levels in both the...

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Autores principales:	Osacka Jana, Koprdova Romana, Tillinger Andrej, Pirnik Zdenko, Kiss Alexander
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2021
Materias:	brain derived neurotrophic factor glucocorticoid receptors c-fos-immunohisto-chemistry haloperidol aripiprazole prefrontal cortex hippocampus rat Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/0da3f6722b604d97a4296b06a4dd5406
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spelling	oai:doaj.org-article:0da3f6722b604d97a4296b06a4dd54062021-12-02T17:22:47ZHaloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress1336-032910.2478/enr-2021-0016https://doaj.org/article/0da3f6722b604d97a4296b06a4dd54062021-07-01T00:00:00Zhttps://doi.org/10.2478/enr-2021-0016https://doaj.org/toc/1336-0329Objective. Changes in the brain derived neurotrophic factor (BDNF) and glucocorticoid receptor (GR) expression in the prefrontal cortex (PFC) and hippocampus (HIP) are associated with psychiatric diseases and stress response. Chronic mild stress (CMS) may alter BDNF as well as GR levels in both the PFC and the HIP. The aim of the present study was to find out whether chronic treatment with a typical antipsychotic haloperidol (HAL) and an atypical antipsychotic aripiprazole (ARI) may modify the CMS effect on the BDNF and GR expression in the above-mentioned structures.Osacka JanaKoprdova RomanaTillinger AndrejPirnik ZdenkoKiss AlexanderSciendoarticlebrain derived neurotrophic factorglucocorticoid receptorsc-fos-immunohisto-chemistryhaloperidolaripiprazoleprefrontal cortexhippocampusratDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 55, Iss 3, Pp 153-162 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	brain derived neurotrophic factor glucocorticoid receptors c-fos-immunohisto-chemistry haloperidol aripiprazole prefrontal cortex hippocampus rat Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	brain derived neurotrophic factor glucocorticoid receptors c-fos-immunohisto-chemistry haloperidol aripiprazole prefrontal cortex hippocampus rat Diseases of the endocrine glands. Clinical endocrinology RC648-665 Osacka Jana Koprdova Romana Tillinger Andrej Pirnik Zdenko Kiss Alexander Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress
description	Objective. Changes in the brain derived neurotrophic factor (BDNF) and glucocorticoid receptor (GR) expression in the prefrontal cortex (PFC) and hippocampus (HIP) are associated with psychiatric diseases and stress response. Chronic mild stress (CMS) may alter BDNF as well as GR levels in both the PFC and the HIP. The aim of the present study was to find out whether chronic treatment with a typical antipsychotic haloperidol (HAL) and an atypical antipsychotic aripiprazole (ARI) may modify the CMS effect on the BDNF and GR expression in the above-mentioned structures.
format	article
author	Osacka Jana Koprdova Romana Tillinger Andrej Pirnik Zdenko Kiss Alexander
author_facet	Osacka Jana Koprdova Romana Tillinger Andrej Pirnik Zdenko Kiss Alexander
author_sort	Osacka Jana
title	Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress
title_short	Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress
title_full	Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress
title_fullStr	Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress
title_full_unstemmed	Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress
title_sort	haloperidol and aripiprazole impact on the bdnf and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress
publisher	Sciendo
publishDate	2021
url	https://doaj.org/article/0da3f6722b604d97a4296b06a4dd5406
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Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress

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