Administration of β-lactam antibiotics and delivery method correlate with intestinal abundances of Bifidobacteria and Bacteroides in early infancy, in Japan

Abstract The intestinal microbiome changes dynamically in early infancy. Colonisation by Bifidobacterium and Bacteroides and development of intestinal immunity is interconnected. We performed a prospective observational cohort study to determine the influence of antibiotics taken by the mother immed...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Naruaki Imoto, Chie Kano, Yumi Aoyagi, Hiroto Morita, Fumitaka Amanuma, Hidekazu Maruyama, Shuko Nojiri, Naoyuki Hashiguchi, Shin Watanabe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0da51fad62ed4f0b9a2816d17e640f96
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0da51fad62ed4f0b9a2816d17e640f96
record_format	dspace
spelling	oai:doaj.org-article:0da51fad62ed4f0b9a2816d17e640f962021-12-02T16:30:57ZAdministration of β-lactam antibiotics and delivery method correlate with intestinal abundances of Bifidobacteria and Bacteroides in early infancy, in Japan10.1038/s41598-021-85670-z2045-2322https://doaj.org/article/0da51fad62ed4f0b9a2816d17e640f962021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85670-zhttps://doaj.org/toc/2045-2322Abstract The intestinal microbiome changes dynamically in early infancy. Colonisation by Bifidobacterium and Bacteroides and development of intestinal immunity is interconnected. We performed a prospective observational cohort study to determine the influence of antibiotics taken by the mother immediately before delivery on the intestinal microbiome of 130 healthy Japanese infants. Faecal samples (383) were collected at 1, 3, and 6 months and analysed using next-generation sequencing. Cefazolin was administered before caesarean sections, whereas ampicillin was administered in cases with premature rupture of the membranes and in Group B Streptococcus-positive cases. Bifidobacterium and Bacteroides were dominant (60–70% mean combined occupancy) at all ages. A low abundance of Bifidobacterium was observed in infants exposed to antibiotics at delivery and at 1 and 3 months, with no difference between delivery methods. A lower abundance of Bacteroides was observed after caesarean section than vaginal delivery, irrespective of antibiotic exposure. Additionally, occupancy by Bifidobacterium at 1 and 3 months and by Bacteroides at 3 months differed between infants with and without siblings. All these differences disappeared at 6 months. Infants exposed to intrapartum antibiotics displayed altered Bifidobacterium abundance, whereas abundance of Bacteroides was largely associated with the delivery method. Existence of siblings also significantly influenced the microbiota composition of infants.Naruaki ImotoChie KanoYumi AoyagiHiroto MoritaFumitaka AmanumaHidekazu MaruyamaShuko NojiriNaoyuki HashiguchiShin WatanabeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Naruaki Imoto Chie Kano Yumi Aoyagi Hiroto Morita Fumitaka Amanuma Hidekazu Maruyama Shuko Nojiri Naoyuki Hashiguchi Shin Watanabe Administration of β-lactam antibiotics and delivery method correlate with intestinal abundances of Bifidobacteria and Bacteroides in early infancy, in Japan
description	Abstract The intestinal microbiome changes dynamically in early infancy. Colonisation by Bifidobacterium and Bacteroides and development of intestinal immunity is interconnected. We performed a prospective observational cohort study to determine the influence of antibiotics taken by the mother immediately before delivery on the intestinal microbiome of 130 healthy Japanese infants. Faecal samples (383) were collected at 1, 3, and 6 months and analysed using next-generation sequencing. Cefazolin was administered before caesarean sections, whereas ampicillin was administered in cases with premature rupture of the membranes and in Group B Streptococcus-positive cases. Bifidobacterium and Bacteroides were dominant (60–70% mean combined occupancy) at all ages. A low abundance of Bifidobacterium was observed in infants exposed to antibiotics at delivery and at 1 and 3 months, with no difference between delivery methods. A lower abundance of Bacteroides was observed after caesarean section than vaginal delivery, irrespective of antibiotic exposure. Additionally, occupancy by Bifidobacterium at 1 and 3 months and by Bacteroides at 3 months differed between infants with and without siblings. All these differences disappeared at 6 months. Infants exposed to intrapartum antibiotics displayed altered Bifidobacterium abundance, whereas abundance of Bacteroides was largely associated with the delivery method. Existence of siblings also significantly influenced the microbiota composition of infants.
format	article
author	Naruaki Imoto Chie Kano Yumi Aoyagi Hiroto Morita Fumitaka Amanuma Hidekazu Maruyama Shuko Nojiri Naoyuki Hashiguchi Shin Watanabe
author_facet	Naruaki Imoto Chie Kano Yumi Aoyagi Hiroto Morita Fumitaka Amanuma Hidekazu Maruyama Shuko Nojiri Naoyuki Hashiguchi Shin Watanabe
author_sort	Naruaki Imoto
title	Administration of β-lactam antibiotics and delivery method correlate with intestinal abundances of Bifidobacteria and Bacteroides in early infancy, in Japan
title_short	Administration of β-lactam antibiotics and delivery method correlate with intestinal abundances of Bifidobacteria and Bacteroides in early infancy, in Japan
title_full	Administration of β-lactam antibiotics and delivery method correlate with intestinal abundances of Bifidobacteria and Bacteroides in early infancy, in Japan
title_fullStr	Administration of β-lactam antibiotics and delivery method correlate with intestinal abundances of Bifidobacteria and Bacteroides in early infancy, in Japan
title_full_unstemmed	Administration of β-lactam antibiotics and delivery method correlate with intestinal abundances of Bifidobacteria and Bacteroides in early infancy, in Japan
title_sort	administration of β-lactam antibiotics and delivery method correlate with intestinal abundances of bifidobacteria and bacteroides in early infancy, in japan
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0da51fad62ed4f0b9a2816d17e640f96
work_keys_str_mv	AT naruakiimoto administrationofblactamantibioticsanddeliverymethodcorrelatewithintestinalabundancesofbifidobacteriaandbacteroidesinearlyinfancyinjapan AT chiekano administrationofblactamantibioticsanddeliverymethodcorrelatewithintestinalabundancesofbifidobacteriaandbacteroidesinearlyinfancyinjapan AT yumiaoyagi administrationofblactamantibioticsanddeliverymethodcorrelatewithintestinalabundancesofbifidobacteriaandbacteroidesinearlyinfancyinjapan AT hirotomorita administrationofblactamantibioticsanddeliverymethodcorrelatewithintestinalabundancesofbifidobacteriaandbacteroidesinearlyinfancyinjapan AT fumitakaamanuma administrationofblactamantibioticsanddeliverymethodcorrelatewithintestinalabundancesofbifidobacteriaandbacteroidesinearlyinfancyinjapan AT hidekazumaruyama administrationofblactamantibioticsanddeliverymethodcorrelatewithintestinalabundancesofbifidobacteriaandbacteroidesinearlyinfancyinjapan AT shukonojiri administrationofblactamantibioticsanddeliverymethodcorrelatewithintestinalabundancesofbifidobacteriaandbacteroidesinearlyinfancyinjapan AT naoyukihashiguchi administrationofblactamantibioticsanddeliverymethodcorrelatewithintestinalabundancesofbifidobacteriaandbacteroidesinearlyinfancyinjapan AT shinwatanabe administrationofblactamantibioticsanddeliverymethodcorrelatewithintestinalabundancesofbifidobacteriaandbacteroidesinearlyinfancyinjapan
_version_	1718383854767570944

Administration of β-lactam antibiotics and delivery method correlate with intestinal abundances of Bifidobacteria and Bacteroides in early infancy, in Japan

Ejemplares similares