Efficient production of vindoline from tabersonine by metabolically engineered Saccharomyces cerevisiae

Liu et al. optimize vindoline biosynthesis in yeast from tabersonine by altering the copy numbers of pathway genes, pairing CYPs with CPRs, engineering the microenvironment for functional expression of CYPs, enhancing cofactor supplies, and optimizing fermentation conditions. By doing so, the author...

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Autores principales: Tengfei Liu, Ying Huang, Lihong Jiang, Chang Dong, Yuanwei Gou, Jiazhang Lian
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/0daa35ca313a41a7b7ca2d89a0328a01
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