Muscle physiology changes induced by every other day feeding and endurance exercise in mice: effects on physical performance.

Every other day feeding (EOD) and exercise induce changes in cell metabolism. The aim of the present work was to know if both EOD and exercise produce similar effects on physical capacity, studying their physiological, biochemical and metabolic effects on muscle. Male OF-1 mice were fed either ad li...

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Autores principales:	Elizabeth Rodríguez-Bies, Sara Santa-Cruz Calvo, Angela Fontán-Lozano, José Peña Amaro, Francisco J Berral de la Rosa, Angel M Carrión, Plácido Navas, Guillermo López-Lluch
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0dafa942a6ab4ee5910e7aee59d9b100
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spelling	oai:doaj.org-article:0dafa942a6ab4ee5910e7aee59d9b1002021-11-18T07:37:04ZMuscle physiology changes induced by every other day feeding and endurance exercise in mice: effects on physical performance.1932-620310.1371/journal.pone.0013900https://doaj.org/article/0dafa942a6ab4ee5910e7aee59d9b1002010-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21085477/?tool=EBIhttps://doaj.org/toc/1932-6203Every other day feeding (EOD) and exercise induce changes in cell metabolism. The aim of the present work was to know if both EOD and exercise produce similar effects on physical capacity, studying their physiological, biochemical and metabolic effects on muscle. Male OF-1 mice were fed either ad libitum (AL) or under EOD. After 18 weeks under EOD, animals were also trained by using a treadmill for another 6 weeks and then analyzed for physical activity. Both, EOD and endurance exercise increased the resistance of animals to extenuating activity and improved motor coordination. Among the groups that showed the highest performance, AL and EOD trained animals, ALT and EODT respectively, only the EODT group was able to increase glucose and triglycerides levels in plasma after extenuating exercise. No high effects on mitochondrial respiratory chain activities or protein levels neither on coenzyme Q levels were found in gastrocnemius muscle. However, exercise and EOD did increase β-oxidation activity in this muscle accompanied by increased CD36 levels in animals fed under EOD and by changes in shape and localization of mitochondria in muscle fibers. Furthermore, EOD and training decreased muscle damage after strenuous exercise. EOD also reduced the levels of lipid peroxidation in muscle. Our results indicate that EOD improves muscle performance and resistance by increasing lipid catabolism in muscle mitochondria at the same time that prevents lipid peroxidation and muscle damage.Elizabeth Rodríguez-BiesSara Santa-Cruz CalvoAngela Fontán-LozanoJosé Peña AmaroFrancisco J Berral de la RosaAngel M CarriónPlácido NavasGuillermo López-LluchPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 11, p e13900 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elizabeth Rodríguez-Bies Sara Santa-Cruz Calvo Angela Fontán-Lozano José Peña Amaro Francisco J Berral de la Rosa Angel M Carrión Plácido Navas Guillermo López-Lluch Muscle physiology changes induced by every other day feeding and endurance exercise in mice: effects on physical performance.
description	Every other day feeding (EOD) and exercise induce changes in cell metabolism. The aim of the present work was to know if both EOD and exercise produce similar effects on physical capacity, studying their physiological, biochemical and metabolic effects on muscle. Male OF-1 mice were fed either ad libitum (AL) or under EOD. After 18 weeks under EOD, animals were also trained by using a treadmill for another 6 weeks and then analyzed for physical activity. Both, EOD and endurance exercise increased the resistance of animals to extenuating activity and improved motor coordination. Among the groups that showed the highest performance, AL and EOD trained animals, ALT and EODT respectively, only the EODT group was able to increase glucose and triglycerides levels in plasma after extenuating exercise. No high effects on mitochondrial respiratory chain activities or protein levels neither on coenzyme Q levels were found in gastrocnemius muscle. However, exercise and EOD did increase β-oxidation activity in this muscle accompanied by increased CD36 levels in animals fed under EOD and by changes in shape and localization of mitochondria in muscle fibers. Furthermore, EOD and training decreased muscle damage after strenuous exercise. EOD also reduced the levels of lipid peroxidation in muscle. Our results indicate that EOD improves muscle performance and resistance by increasing lipid catabolism in muscle mitochondria at the same time that prevents lipid peroxidation and muscle damage.
format	article
author	Elizabeth Rodríguez-Bies Sara Santa-Cruz Calvo Angela Fontán-Lozano José Peña Amaro Francisco J Berral de la Rosa Angel M Carrión Plácido Navas Guillermo López-Lluch
author_facet	Elizabeth Rodríguez-Bies Sara Santa-Cruz Calvo Angela Fontán-Lozano José Peña Amaro Francisco J Berral de la Rosa Angel M Carrión Plácido Navas Guillermo López-Lluch
author_sort	Elizabeth Rodríguez-Bies
title	Muscle physiology changes induced by every other day feeding and endurance exercise in mice: effects on physical performance.
title_short	Muscle physiology changes induced by every other day feeding and endurance exercise in mice: effects on physical performance.
title_full	Muscle physiology changes induced by every other day feeding and endurance exercise in mice: effects on physical performance.
title_fullStr	Muscle physiology changes induced by every other day feeding and endurance exercise in mice: effects on physical performance.
title_full_unstemmed	Muscle physiology changes induced by every other day feeding and endurance exercise in mice: effects on physical performance.
title_sort	muscle physiology changes induced by every other day feeding and endurance exercise in mice: effects on physical performance.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/0dafa942a6ab4ee5910e7aee59d9b100
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Muscle physiology changes induced by every other day feeding and endurance exercise in mice: effects on physical performance.

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