Orthologous microRNA genes are located in cancer-associated genomic regions in human and mouse.

<h4>Background</h4>MicroRNAs (miRNAs) are short non-coding RNAs that regulate differentiation and development in many organisms and play an important role in cancer.<h4>Methodology/principal findings</h4>Using a public database of mapped retroviral insertion sites from variou...

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Autores principales:	Igor V Makunin, Michael Pheasant, Cas Simons, John S Mattick
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2007
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0db3122736d0459ca90febf5a874625d
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spelling	oai:doaj.org-article:0db3122736d0459ca90febf5a874625d2021-11-25T06:10:30ZOrthologous microRNA genes are located in cancer-associated genomic regions in human and mouse.1932-620310.1371/journal.pone.0001133https://doaj.org/article/0db3122736d0459ca90febf5a874625d2007-11-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0001133https://doaj.org/toc/1932-6203<h4>Background</h4>MicroRNAs (miRNAs) are short non-coding RNAs that regulate differentiation and development in many organisms and play an important role in cancer.<h4>Methodology/principal findings</h4>Using a public database of mapped retroviral insertion sites from various mouse models of cancer we demonstrate that MLV-derived retroviral inserts are enriched in close proximity to mouse miRNA loci. Clustered inserts from cancer-associated regions (Common Integration Sites, CIS) have a higher association with miRNAs than non-clustered inserts. Ten CIS-associated miRNA loci containing 22 miRNAs are located within 10 kb of known CIS insertions. Only one CIS-associated miRNA locus overlaps a RefSeq protein-coding gene and six loci are located more than 10 kb from any RefSeq gene. CIS-associated miRNAs on average are more conserved in vertebrates than miRNAs associated with non-CIS inserts and their human homologs are also located in regions perturbed in cancer. In addition we show that miRNA genes are enriched around promoter and/or terminator regions of RefSeq genes in both mouse and human.<h4>Conclusions/significance</h4>We provide a list of ten miRNA loci potentially involved in the development of blood cancer or brain tumors. There is independent experimental support from other studies for the involvement of miRNAs from at least three CIS-associated miRNA loci in cancer development.Igor V MakuninMichael PheasantCas SimonsJohn S MattickPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 2, Iss 11, p e1133 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Igor V Makunin Michael Pheasant Cas Simons John S Mattick Orthologous microRNA genes are located in cancer-associated genomic regions in human and mouse.
description	<h4>Background</h4>MicroRNAs (miRNAs) are short non-coding RNAs that regulate differentiation and development in many organisms and play an important role in cancer.<h4>Methodology/principal findings</h4>Using a public database of mapped retroviral insertion sites from various mouse models of cancer we demonstrate that MLV-derived retroviral inserts are enriched in close proximity to mouse miRNA loci. Clustered inserts from cancer-associated regions (Common Integration Sites, CIS) have a higher association with miRNAs than non-clustered inserts. Ten CIS-associated miRNA loci containing 22 miRNAs are located within 10 kb of known CIS insertions. Only one CIS-associated miRNA locus overlaps a RefSeq protein-coding gene and six loci are located more than 10 kb from any RefSeq gene. CIS-associated miRNAs on average are more conserved in vertebrates than miRNAs associated with non-CIS inserts and their human homologs are also located in regions perturbed in cancer. In addition we show that miRNA genes are enriched around promoter and/or terminator regions of RefSeq genes in both mouse and human.<h4>Conclusions/significance</h4>We provide a list of ten miRNA loci potentially involved in the development of blood cancer or brain tumors. There is independent experimental support from other studies for the involvement of miRNAs from at least three CIS-associated miRNA loci in cancer development.
format	article
author	Igor V Makunin Michael Pheasant Cas Simons John S Mattick
author_facet	Igor V Makunin Michael Pheasant Cas Simons John S Mattick
author_sort	Igor V Makunin
title	Orthologous microRNA genes are located in cancer-associated genomic regions in human and mouse.
title_short	Orthologous microRNA genes are located in cancer-associated genomic regions in human and mouse.
title_full	Orthologous microRNA genes are located in cancer-associated genomic regions in human and mouse.
title_fullStr	Orthologous microRNA genes are located in cancer-associated genomic regions in human and mouse.
title_full_unstemmed	Orthologous microRNA genes are located in cancer-associated genomic regions in human and mouse.
title_sort	orthologous microrna genes are located in cancer-associated genomic regions in human and mouse.
publisher	Public Library of Science (PLoS)
publishDate	2007
url	https://doaj.org/article/0db3122736d0459ca90febf5a874625d
work_keys_str_mv	AT igorvmakunin orthologousmicrornagenesarelocatedincancerassociatedgenomicregionsinhumanandmouse AT michaelpheasant orthologousmicrornagenesarelocatedincancerassociatedgenomicregionsinhumanandmouse AT cassimons orthologousmicrornagenesarelocatedincancerassociatedgenomicregionsinhumanandmouse AT johnsmattick orthologousmicrornagenesarelocatedincancerassociatedgenomicregionsinhumanandmouse
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Orthologous microRNA genes are located in cancer-associated genomic regions in human and mouse.

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